Echinocandins

"Echinocandins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Cyclic hexapeptides of proline-ornithine-threonine-proline-threonine-serine. The cyclization with a single non-peptide bond can lead them to be incorrectly called DEPSIPEPTIDES, but the echinocandins lack ester links. Antifungal activity is via inhibition of 1,3-beta-glucan synthase production of BETA-GLUCANS.

Descriptor ID	D054714
MeSH Number(s)	D12.644.641.311
Concept/Terms	Echinocandins Echinocandins Mulundocandins Mulundocandins Aculeacins Aculeacins Pneumocandins Pneumocandins

Below are MeSH descriptors whose meaning is more general than "Echinocandins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Peptides, Cyclic [D12.644.641]
Echinocandins [D12.644.641.311]

Below are MeSH descriptors whose meaning is related to "Echinocandins".

Below are MeSH descriptors whose meaning is more specific than "Echinocandins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Echinocandins" by people in this website by year, and whether "Echinocandins" was a major or minor topic of these publications.

Bar chart showing 81 publications over 17 distinct years, with a maximum of 9 publications in 2014

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	0	1	1
2003	0	4	4
2004	0	3	3
2005	0	6	6
2006	0	5	5
2007	3	4	7
2008	6	1	7
2009	4	1	5
2010	4	1	5
2011	5	1	6
2012	4	1	5
2013	2	2	4
2014	4	5	9
2015	7	0	7
2016	0	3	3
2017	2	0	2
2018	1	1	2

Below are the most recent publications written about "Echinocandins" by people in Profiles.

Foster CE, Edwards MS, Brackett J, Schady DA, Healy CM, Baker CJ. Trichosporonosis in Pediatric Patients With a Hematologic Disorder. J Pediatric Infect Dis Soc. 2018 Aug 17; 7(3):199-204.

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Sofjan AK, Mitchell A, Shah DN, Nguyen T, Sim M, Trojcak A, Beyda ND, Garey KW. Rezafungin (CD101), a next-generation echinocandin: A systematic literature review and assessment of possible place in therapy. J Glob Antimicrob Resist. 2018 09; 14:58-64.

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Le A, Farmakiotis D, Tarrand JJ, Kontoyiannis DP. Initial Treatment of Cancer Patients with Fluconazole-Susceptible Dose-Dependent Candida glabrata Fungemia: Better Outcome with an Echinocandin or Polyene Compared to an Azole? Antimicrob Agents Chemother. 2017 08; 61(8).

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Kontoyiannis DP, Bassetti M, Nucci M, Capparella MR, Yan JL, Aram J, Hogan PA. Anidulafungin for the treatment of candidaemia caused by Candida parapsilosis: Analysis of pooled data from six prospective clinical studies. Mycoses. 2017 Oct; 60(10):663-667.

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Patterson TF, Thompson GR, Denning DW, Fishman JA, Hadley S, Herbrecht R, Kontoyiannis DP, Marr KA, Morrison VA, Nguyen MH, Segal BH, Steinbach WJ, Stevens DA, Walsh TJ, Wingard JR, Young JA, Bennett JE. Executive Summary: Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America. Clin Infect Dis. 2016 08 15; 63(4):433-42.

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Patterson TF, Thompson GR, Denning DW, Fishman JA, Hadley S, Herbrecht R, Kontoyiannis DP, Marr KA, Morrison VA, Nguyen MH, Segal BH, Steinbach WJ, Stevens DA, Walsh TJ, Wingard JR, Young JA, Bennett JE. Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America. Clin Infect Dis. 2016 08 15; 63(4):e1-e60.

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Healey KR, Zhao Y, Perez WB, Lockhart SR, Sobel JD, Farmakiotis D, Kontoyiannis DP, Sanglard D, Taj-Aldeen SJ, Alexander BD, Jimenez-Ortigosa C, Shor E, Perlin DS. Prevalent mutator genotype identified in fungal pathogen Candida glabrata promotes multi-drug resistance. Nat Commun. 2016 Mar 29; 7:11128.

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Ioannou P, Andrianaki A, Akoumianaki T, Kyrmizi I, Albert N, Perlin D, Samonis G, Kontoyiannis DP, Chamilos G. Albumin Enhances Caspofungin Activity against Aspergillus Species by Facilitating Drug Delivery to Germinating Hyphae. Antimicrob Agents Chemother. 2015 Dec 07; 60(3):1226-33.

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Jung DS, Tverdek FP, Jiang Y, Kontoyiannis DP. Switching to anidulafungin from caspofungin in cancer patients in the setting of liver dysfunction is associated with improvement of liver function tests. J Antimicrob Chemother. 2015 Nov; 70(11):3100-6.

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Beyda ND, Liao G, Endres BT, Lewis RE, Garey KW. Innate inflammatory response and immunopharmacologic activity of micafungin, caspofungin, and voriconazole against wild-type and FKS mutant Candida glabrata isolates. Antimicrob Agents Chemother. 2015 Sep; 59(9):5405-12.

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