Telomeric Repeat Binding Protein 2
"Telomeric Repeat Binding Protein 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A ubiquitously expressed telomere-binding protein that is present at TELOMERES throughout the cell cycle. It is a suppressor of telomere elongation and may be involved in stabilization of telomere length. It is structurally different from TELOMERIC REPEAT BINDING PROTEIN 1 in that it contains basic N-terminal amino acid residues.
| Descriptor ID |
D035341
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| MeSH Number(s) |
D12.776.260.735.875 D12.776.660.235.700.875
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Telomeric Repeat Binding Protein 2".
Below are MeSH descriptors whose meaning is more specific than "Telomeric Repeat Binding Protein 2".
This graph shows the total number of publications written about "Telomeric Repeat Binding Protein 2" by people in this website by year, and whether "Telomeric Repeat Binding Protein 2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Telomeric Repeat Binding Protein 2" by people in Profiles.
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FOXK1 Participates in DNA Damage Response by Controlling 53BP1 Function. Cell Rep. 2020 08 11; 32(6):108018.
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The C-Terminal Extension Unique to the Long Isoform of the Shelterin Component TIN2 Enhances Its Interaction with TRF2 in a Phosphorylation- and Dyskeratosis Congenita Cluster-Dependent Fashion. Mol Cell Biol. 2018 06 15; 38(12).
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TRF2 interaction with Ku heterotetramerization interface gives insight into c-NHEJ prevention at human telomeres. Cell Rep. 2013 Oct 17; 5(1):194-206.
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Human telomeric proteins occupy selective interstitial sites. Cell Res. 2011 Jul; 21(7):1013-27.
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TRF2 functions as a protein hub and regulates telomere maintenance by recognizing specific peptide motifs. Nat Struct Mol Biol. 2009 Apr; 16(4):372-9.
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Expression of telomere-associated genes as prognostic markers for overall survival in patients with non-small cell lung cancer. Clin Cancer Res. 2006 Oct 01; 12(19):5720-5.
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A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly. Proc Natl Acad Sci U S A. 2006 Aug 08; 103(32):11874-9.
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Roles of tumor suppressor and telomere maintenance genes in cancer and aging--an epidemiological study. Carcinogenesis. 2005 Oct; 26(10):1741-7.
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Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins. J Biol Chem. 2004 Dec 03; 279(49):51338-42.
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Caspase-dependent apoptosis induced by telomere cleavage and TRF2 loss. Neoplasia. 2000 Jul-Aug; 2(4):339-45.