"Phenformin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A biguanide hypoglycemic agent with actions and uses similar to those of METFORMIN. Although it is generally considered to be associated with an unacceptably high incidence of lactic acidosis, often fatal, it is still available in some countries. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290)
| Descriptor ID |
D010629
|
| MeSH Number(s) |
D02.078.370.141.700
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Phenformin".
Below are MeSH descriptors whose meaning is more specific than "Phenformin".
This graph shows the total number of publications written about "Phenformin" by people in this website by year, and whether "Phenformin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2012 | 1 | 0 | 1 |
| 2016 | 1 | 1 | 2 |
| 2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "Phenformin" by people in Profiles.
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Treatment of Pancreatic Cancer Patient-Derived Xenograft Panel with Metabolic Inhibitors Reveals Efficacy of Phenformin. Clin Cancer Res. 2017 Sep 15; 23(18):5639-5647.
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lncRNA NBR2 modulates cancer cell sensitivity to phenformin through GLUT1. Cell Cycle. 2016 Dec 16; 15(24):3471-3481.
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Biguanides sensitize leukemia cells to ABT-737-induced apoptosis by inhibiting mitochondrial electron transport. Oncotarget. 2016 Aug 09; 7(32):51435-51449.
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Phenformin as prophylaxis and therapy in breast cancer xenografts. Br J Cancer. 2012 Mar 13; 106(6):1117-22.
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Elevation of the blood lactate concentration by alkali therapy without requiring additional lactic acid accumulation: theoretical considerations. Crit Care Med. 1982 May; 10(5):323-6.
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Role of sorbitol pathway in neuropathy. Adv Metab Disord. 1973; 2:Suppl 2:417-32.