12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
"12-Hydroxy-5,8,10,14-eicosatetraenoic Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A lipoxygenase metabolite of ARACHIDONIC ACID. It is a highly selective ligand used to label mu-opioid receptors in both membranes and tissue sections. The 12-S-HETE analog has been reported to augment tumor cell metastatic potential through activation of protein kinase C. (J Pharmacol Exp Ther 1995; 274(3):1545-51; J Natl Cancer Inst 1994; 86(15):1145-51)
| Descriptor ID |
D019377
|
| MeSH Number(s) |
D10.251.355.255.100.300.425 D10.251.355.310.166.550.425
|
| Concept/Terms |
12-S-HETE- 12-S-HETE
- 12-S-Hydroxyeicosatetraenoic Acid
- 12 S Hydroxyeicosatetraenoic Acid
- Acid, 12-S-Hydroxyeicosatetraenoic
|
Below are MeSH descriptors whose meaning is more general than "12-Hydroxy-5,8,10,14-eicosatetraenoic Acid".
Below are MeSH descriptors whose meaning is more specific than "12-Hydroxy-5,8,10,14-eicosatetraenoic Acid".
This graph shows the total number of publications written about "12-Hydroxy-5,8,10,14-eicosatetraenoic Acid" by people in this website by year, and whether "12-Hydroxy-5,8,10,14-eicosatetraenoic Acid" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
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Below are the most recent publications written about "12-Hydroxy-5,8,10,14-eicosatetraenoic Acid" by people in Profiles.
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Arachidonic acid metabolism in human prostate cancer. Int J Oncol. 2012 Oct; 41(4):1495-503.
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Pomegranate fruit extract impairs invasion and motility in human breast cancer. Integr Cancer Ther. 2009 Sep; 8(3):242-53.
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Evaluation of targeted arterial delivery of the branched chain fatty acid 12-methyltetradecanoic acid as a novel therapy for solid tumors. J Exp Ther Oncol. 2005; 5(1):55-68.
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Aberrant arachidonic acid metabolism in esophageal adenocarcinogenesis, and the effects of sulindac, nordihydroguaiaretic acid, and alpha-difluoromethylornithine on tumorigenesis in a rat surgical model. Carcinogenesis. 2002 Dec; 23(12):2095-102.
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Simultaneous quantification of arachidonic acid metabolites in cultured tumor cells using high-performance liquid chromatography/electrospray ionization tandem mass spectrometry. Anal Biochem. 2001 Oct 15; 297(2):183-90.
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Human 12(R)-lipoxygenase and the mouse ortholog. Molecular cloning, expression, and gene chromosomal assignment. J Biol Chem. 1998 Dec 11; 273(50):33540-7.
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Epidermis contains platelet-type 12-lipoxygenase that is overexpressed in germinal layer keratinocytes in psoriasis. Am J Physiol. 1994 Jan; 266(1 Pt 1):C243-53.
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Selective expression of an arachidonate 12-lipoxygenase by pancreatic islet beta-cells. Am J Physiol. 1992 Nov; 263(5 Pt 1):E828-36.