"Photoaffinity Labels" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Biologically active molecules which are covalently bound to the enzymes or binding proteins normally acting on them. Binding occurs due to activation of the label by ultraviolet light. These labels are used primarily to identify binding sites on proteins.
| Descriptor ID |
D019920
|
| MeSH Number(s) |
D27.720.470.410.080.600
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Photoaffinity Labels".
Below are MeSH descriptors whose meaning is more specific than "Photoaffinity Labels".
This graph shows the total number of publications written about "Photoaffinity Labels" by people in this website by year, and whether "Photoaffinity Labels" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2009 | 0 | 2 | 2 |
| 2011 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "Photoaffinity Labels" by people in Profiles.
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Identification of alcohol-binding site(s) in proteins using diazirine-based photoaffinity labeling and mass spectrometry. Chem Biol Drug Des. 2019 06; 93(6):1158-1165.
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Nucleosome mobilization by ISW2 requires the concerted action of the ATPase and SLIDE domains. Nat Struct Mol Biol. 2013 Feb; 20(2):222-9.
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Aliphatic diazirines as photoaffinity probes for proteins: recent developments. Chem Rev. 2011 Aug 10; 111(8):4405-17.
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Modulation of gamma-secretase specificity using small molecule allosteric inhibitors. Proc Natl Acad Sci U S A. 2009 Dec 01; 106(48):20228-33.
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Small-molecule activators of insulin-degrading enzyme discovered through high-throughput compound screening. PLoS One. 2009; 4(4):e5274.
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Site-directed DNA crosslinking of large multisubunit protein-DNA complexes. Methods Mol Biol. 2009; 543:453-74.
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Role of transmembrane domain/transmembrane domain interfaces of P-glycoprotein (ABCB1) in solute transport. Convergent information from photoaffinity labeling, site directed mutagenesis and in silico importance prediction. Curr Med Chem. 2006; 13(7):793-805.
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Site-directed histone-DNA contact mapping for analysis of nucleosome dynamics. Methods Enzymol. 2004; 375:193-210.
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Site-directed DNA photoaffinity labeling of RNA polymerase III transcription complexes. Methods Mol Biol. 2001; 148:363-81.
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Two novel dATP analogs for DNA photoaffinity labeling. Nucleic Acids Res. 2000 Nov 01; 28(21):4382-90.