Spinocerebellar Ataxias

"Spinocerebellar Ataxias" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A group of dominantly inherited, predominately late-onset, cerebellar ataxias which have been divided into multiple subtypes based on clinical features and genetic mapping. Progressive ataxia is a central feature of these conditions, and in certain subtypes POLYNEUROPATHY; DYSARTHRIA; visual loss; and other disorders may develop. (From Joynt, Clinical Neurology, 1997, Ch65, pp 12-17; J Neuropathol Exp Neurol 1998 Jun;57(6):531-43)

Descriptor ID	D020754
MeSH Number(s)	C10.228.140.252.190.530 C10.228.140.252.700.700 C10.228.854.787.875 C10.574.500.825.700 C10.597.350.090.500.530 C16.320.400.780.875
Concept/Terms	Spinocerebellar Ataxias Spinocerebellar Ataxias Ataxia, Spinocerebellar Ataxias, Spinocerebellar Spinocerebellar Ataxia Dominantly-Inherited Spinocerebellar Ataxias Ataxia, Dominantly-Inherited Spinocerebellar Ataxias, Dominantly-Inherited Spinocerebellar Dominantly Inherited Spinocerebellar Ataxias Dominantly-Inherited Spinocerebellar Ataxia Spinocerebellar Ataxia, Dominantly-Inherited Spinocerebellar Ataxias, Dominantly-Inherited Spinocerebellar Ataxias, Dominantly Inherited Spinocerebellar Atrophies Atrophies, Spinocerebellar Atrophy, Spinocerebellar Spinocerebellar Atrophy Spinocerebellar Ataxia Type 2 Spinocerebellar Ataxia Type 2 Type 2 Spinocerebellar Ataxia Spinocerebellar Ataxia 2 Ataxia 2, Spinocerebellar Ataxia 2s, Spinocerebellar Spinocerebellar Ataxia 2s Wadia-Swami Syndrome Syndrome, Wadia-Swami Cerebellar Degeneration with Slow Eye Movements Olivopontocerebellar Atrophy II Atrophy II, Olivopontocerebellar Atrophy IIs, Olivopontocerebellar II, Olivopontocerebellar Atrophy IIs, Olivopontocerebellar Atrophy Olivopontocerebellar Atrophy IIs Spinocerebellar Atrophy II Atrophy II, Spinocerebellar Atrophy IIs, Spinocerebellar II, Spinocerebellar Atrophy IIs, Spinocerebellar Atrophy Spinocerebellar Atrophy IIs Olivopontocerebellar Atrophy 2 Atrophy 2, Olivopontocerebellar Atrophy 2s, Olivopontocerebellar Olivopontocerebellar Atrophy 2s Spinocerebellar Ataxia with Slow Eye Movements Spinocerebellar Ataxia, Cuban Type Spinocerebellar Atrophy 2 Atrophy 2, Spinocerebellar Atrophy 2s, Spinocerebellar Spinocerebellar Atrophy 2s Spinocerebellar Degeneration with Slow Eye Movements Wadia Swami Syndrome Swami Syndrome, Wadia Syndrome, Wadia Swami Olivopontocerebellar Atrophy, Holguin Type Spinocerebellar Ataxia-2 Spinocerebellar Ataxia Type 7 Spinocerebellar Ataxia Type 7 Type 7 Spinocerebellar Ataxia OPCA with Retinal Degeneration Olivopontocerebellar Atrophy III Atrophy III, Olivopontocerebellar Olivopontocerebellar Atrophy IIIs Autosomal Dominant Cerebellar Ataxia, Type II OPCA with Macular Degeneration and External Ophthalmoplegia Spinocerebellar Ataxia-7 Spinocerebellar Ataxia 7 Ataxia 7, Spinocerebellar Ataxia 7s, Spinocerebellar Spinocerebellar Ataxia 7s Spinocerebellar Ataxia Type 5 Spinocerebellar Ataxia Type 5 Type 5 Spinocerebellar Ataxia Spinocerebellar Ataxia 5 Ataxia 5, Spinocerebellar Ataxia 5s, Spinocerebellar Spinocerebellar Ataxia 5s Spinocerebellar Ataxia-5 Spinocerebellar Ataxia Type 6 Spinocerebellar Ataxia Type 6 Type 6 Spinocerebellar Ataxia Spinocerebellar Ataxia 6 Ataxia 6, Spinocerebellar Ataxia 6s, Spinocerebellar Spinocerebellar Ataxia 6s Spinocerebellar Ataxia-6 Spinocerebellar Ataxia Type 1 Spinocerebellar Ataxia Type 1 Type 1 Spinocerebellar Ataxia Spinocerebellar Ataxia 1 Ataxia 1, Spinocerebellar Spinocerebellar Ataxia 1s Spinocerebellar Atrophy I Atrophy I, Spinocerebellar Spinocerebellar Atrophy Is SCA1 SCA1s Cerebelloparenchymal Disorder I Cerebelloparenchymal Disorder Is Menzel Type OPCA OPCA, Menzel Type Schut-Haymaker Type OPCA OPCA, Schut-Haymaker Type Schut Haymaker Type OPCA Olivopontocerebellar Atrophy IV Atrophy IV, Olivopontocerebellar Atrophy IVs, Olivopontocerebellar Olivopontocerebellar Atrophy IVs Spinocerebellar Ataxia-1 Olivopontocerebellar Atrophy I Atrophy I, Olivopontocerebellar Olivopontocerebellar Atrophy Is Spinocerebellar Ataxia Type 4 Spinocerebellar Ataxia Type 4 Spinocerebellar Ataxia 4 Ataxia 4, Spinocerebellar Ataxia 4s, Spinocerebellar Spinocerebellar Ataxia 4s Spinocerebellar Ataxia, Autosomal Dominant, with Sensory Axonal Neuropathy Spinocerebellar Ataxia-4 Type 4 Spinocerebellar Ataxia

Below are MeSH descriptors whose meaning is more general than "Spinocerebellar Ataxias".

Diseases [C]
Nervous System Diseases [C10]
Central Nervous System Diseases [C10.228]
Brain Diseases [C10.228.140]
Cerebellar Diseases [C10.228.140.252]
Cerebellar Ataxia [C10.228.140.252.190]
Spinocerebellar Ataxias [C10.228.140.252.190.530]
Spinocerebellar Degenerations [C10.228.140.252.700]
Spinocerebellar Ataxias [C10.228.140.252.700.700]
Spinal Cord Diseases [C10.228.854]
Spinocerebellar Degenerations [C10.228.854.787]
Spinocerebellar Ataxias [C10.228.854.787.875]
Neurodegenerative Diseases [C10.574]
Heredodegenerative Disorders, Nervous System [C10.574.500]
Spinocerebellar Degenerations [C10.574.500.825]
Spinocerebellar Ataxias [C10.574.500.825.700]
Neurologic Manifestations [C10.597]
Dyskinesias [C10.597.350]
Ataxia [C10.597.350.090]
Cerebellar Ataxia [C10.597.350.090.500]
Spinocerebellar Ataxias [C10.597.350.090.500.530]
Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
Genetic Diseases, Inborn [C16.320]
Heredodegenerative Disorders, Nervous System [C16.320.400]
Spinocerebellar Degenerations [C16.320.400.780]
Spinocerebellar Ataxias [C16.320.400.780.875]

Below are MeSH descriptors whose meaning is related to "Spinocerebellar Ataxias".

Below are MeSH descriptors whose meaning is more specific than "Spinocerebellar Ataxias".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Spinocerebellar Ataxias" by people in this website by year, and whether "Spinocerebellar Ataxias" was a major or minor topic of these publications.

Bar chart showing 142 publications over 21 distinct years, with a maximum of 18 publications in 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	4	2	6
2001	4	0	4
2002	10	0	10
2003	6	2	8
2004	7	0	7
2005	6	2	8
2006	1	1	2
2007	8	2	10
2008	5	2	7
2009	1	0	1
2010	4	0	4
2011	7	0	7
2012	6	2	8
2013	13	5	18
2014	3	0	3
2015	8	0	8
2016	3	0	3
2017	9	0	9
2018	10	0	10
2019	4	2	6
2020	3	0	3

Below are the most recent publications written about "Spinocerebellar Ataxias" by people in Profiles.

Vogel AP, Magee M, Torres-Vega R, Medrano-Montero J, Cyngler MP, Kruse M, Rojas S, Cubillos SC, Canento T, Maldonado F, Vazquez-Mojena Y, Ilg W, Rodríguez-Labrada R, Velázquez-Pérez L, Synofzik M. Features of speech and swallowing dysfunction in pre-ataxic spinocerebellar ataxia type 2. Neurology. 2020 07 14; 95(2):e194-e205.

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Arruda WO, Meira AT, Ono SE, de Carvalho Neto A, Ferreira MG, Raskin S, Ferreira Camargo CH, Ashizawa T, Ghizoni Teive HA. Cerebellar and thalamic degeneration in spinocerebellar ataxia type 10. Parkinsonism Relat Disord. 2020 07; 76:76-77.

View in: PubMed
Hashem V, Tiwari A, Bewick B, Teive HAG, Moscovich M, Schüele B, Bushara K, Bower M, Rasmussen A, Tsai YC, Clark T, McFarland K, Ashizawa T. Pulse-Field capillary electrophoresis of repeat-primed PCR amplicons for analysis of large repeats in Spinocerebellar Ataxia Type 10. PLoS One. 2020; 15(3):e0228789.

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Domingues BMD, Nascimento FA, Meira AT, Moro A, Raskin S, Ashizawa T, Teive HAG. Clinical and Genetic Evaluation of Spinocerebellar Ataxia Type 10 in 16 Brazilian Families. Cerebellum. 2019 Oct; 18(5):849-854.

View in: PubMed
Nascimento FA, Rodrigues VOR, Pelloso FC, Camargo CHF, Moro A, Raskin S, Ashizawa T, Teive HAG. Spinocerebellar ataxias in Southern Brazil: Genotypic and phenotypic evaluation of 213 families. Clin Neurol Neurosurg. 2019 Sep; 184:105427.

View in: PubMed
Niemann N, Jankovic J. Juvenile parkinsonism: Differential diagnosis, genetics, and treatment. Parkinsonism Relat Disord. 2019 10; 67:74-89.

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Lai RY, Tomishon D, Figueroa KP, Pulst SM, Perlman S, Wilmot G, Gomez CM, Schmahmann JD, Paulson H, Shakkottai VG, Ying SH, Zesiewicz T, Bushara K, Geschwind M, Xia G, Subramony SH, Ashizawa T, Kuo SH. Tremor in the Degenerative Cerebellum: Towards the Understanding of Brain Circuitry for Tremor. Cerebellum. 2019 Jun; 18(3):519-526.

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Moscovich M, Munhoz RP, Moro A, Raskin S, McFarland K, Ashizawa T, Teive HAG, Silveira-Moriyama L. Olfactory Function in SCA10. Cerebellum. 2019 Feb; 18(1):85-90.

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Ashizawa AT, Holt J, Faust K, Liu W, Tiwari A, Zhang N, Ashizawa T. Intravenously Administered Novel Liposomes, DCL64, Deliver Oligonucleotides to Cerebellar Purkinje Cells. Cerebellum. 2019 Feb; 18(1):99-108.

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Friedrich J, Kordasiewicz HB, O'Callaghan B, Handler HP, Wagener C, Duvick L, Swayze EE, Rainwater O, Hofstra B, Benneyworth M, Nichols-Meade T, Yang P, Chen Z, Ortiz JP, Clark HB, Öz G, Larson S, Zoghbi HY, Henzler C, Orr HT. Antisense oligonucleotide-mediated ataxin-1 reduction prolongs survival in SCA1 mice and reveals disease-associated transcriptome profiles. JCI Insight. 2018 11 02; 3(21).

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