"alpha-MSH" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 13-amino acid peptide derived from proteolytic cleavage of ADRENOCORTICOTROPIC HORMONE, the N-terminal segment of ACTH. ACTH (1-13) is amidated at the C-terminal to form ACTH (1-13)NH2 which in turn is acetylated to form alpha-MSH in the secretory granules. Alpha-MSH stimulates the synthesis and distribution of MELANIN in MELANOCYTES in mammals and MELANOPHORES in lower vertebrates.
| Descriptor ID |
D000521
|
| MeSH Number(s) |
D06.472.699.327.935.179 D06.472.699.327.935.531.750.050 D06.472.699.631.525.600.179 D06.472.699.631.525.600.531.750.050 D12.644.400.400.935.179 D12.644.400.400.935.531.750.050 D12.644.400.460.050 D12.644.548.365.935.179 D12.644.548.365.935.531.750.050 D12.644.548.691.525.690.179 D12.644.548.691.525.690.531.750.050 D12.776.631.650.405.935.179 D12.776.631.650.405.935.531.750.050 D12.776.631.650.460.050
|
| Concept/Terms |
alpha-MSH- alpha-MSH
- alpha MSH
- alpha-Melanotropin
- alpha Melanotropin
- Acetylated ACTH (1-13)NH2
- alpha-Melanocyte-Stimulating Hormone
- Hormone, alpha-Melanocyte-Stimulating
- alpha Melanocyte Stimulating Hormone
- MSH, alpha
ACTH (1-13)NH2- ACTH (1-13)NH2
- (Desacetyl)alpha-MSH
- DE-alpha-MSH
- MSH, (Desacetyl)alpha-
- Des-Acetyl MSH
- MSH, Des-Acetyl
- Desacetyl alpha-MSH
- Desacetyl alpha MSH
- alpha-MSH, Desacetyl
- Desacetyl alpha-Melanocyte-Stimulating Hormone
- Desacetyl alpha Melanocyte Stimulating Hormone
- Hormone, Desacetyl alpha-Melanocyte-Stimulating
- alpha-Melanocyte-Stimulating Hormone, Desacetyl
- (Des-Acetyl)-alpha-MSH
- Adrenocorticotropin (1-13)NH2
|
Below are MeSH descriptors whose meaning is more general than "alpha-MSH".
Below are MeSH descriptors whose meaning is more specific than "alpha-MSH".
This graph shows the total number of publications written about "alpha-MSH" by people in this website by year, and whether "alpha-MSH" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 2 | 2 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 2 | 0 | 2 |
| 2019 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
| 2022 | 1 | 0 | 1 |
| 2023 | 0 | 2 | 2 |
| 2024 | 2 | 1 | 3 |
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click here.
Below are the most recent publications written about "alpha-MSH" by people in Profiles.
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Investigation of setmelanotide, an MC4R agonist, for obesity in individuals with Smith-Magenis syndrome. Obes Res Clin Pract. 2024 Jul-Aug; 18(4):301-307.
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Effect of Ibuprofen as an Albumin Binder on Melanoma-Targeting Properties of 177Lu-Labeled Ibuprofen-Conjugated Alpha-Melanocyte-Stimulating Hormone Peptides. Mol Pharm. 2024 Aug 05; 21(8):4004-4011.
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Therapeutic Strategies Against Metabolic Imbalance in a Male Mouse Model With 5-HT2CR Loss-of-Function. Endocrinology. 2024 May 27; 165(7).
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Effects of Polyethylene Glycol and 8-Aminooctanoic Acid Linkers on Melanoma Uptake of [99mTc]Tc-Tricarbonyl-NOTA-Conjugated Lactam-Cyclized a-MSH Peptides. Bioconjug Chem. 2023 05 17; 34(5):934-940.
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The melanocortin action is biased toward protection from weight loss in mice. Nat Commun. 2023 04 17; 14(1):2200.
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Novel 64Cu-Labeled NOTA-Conjugated Lactam-Cyclized Alpha-Melanocyte-Stimulating Hormone Peptides with Enhanced Tumor to Kidney Uptake Ratios. Mol Pharm. 2022 07 04; 19(7):2535-2541.
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The Effect of Albumin-Binding Moiety on Tumor Targeting and Biodistribution Properties of 67Ga-Labeled Albumin Binder-Conjugated Alpha-Melanocyte-Stimulating Hormone Peptides. Cancer Biother Radiopharm. 2022 Feb; 37(1):47-55.
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Facile preparation of a novel Ga-67-labeled NODAGA-conjugated lactam-cyclized alpha-MSH peptide at room temperature for melanoma targeting. Bioorg Med Chem Lett. 2020 12 15; 30(24):127627.
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Melanoma-Targeting Property of Y-90-Labeled Lactam-Cyclized a-Melanocyte-Stimulating Hormone Peptide. Cancer Biother Radiopharm. 2019 Nov; 34(9):597-603.
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Central Sirt1 regulates body weight and energy expenditure along with the POMC-derived peptide a-MSH and the processing enzyme CPE production in diet-induced obese male rats. Endocrinology. 2015 Mar; 156(3):961-74.