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WEN-HSIANG CHEN

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
Address1102 BATES
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Mo T, Joffe M, Cubasch H, Galukande M, Parham G, Pinder L, Zietsman A, Anderson BO, Naamala A, Kaggwa A, Nakazibwe T, Nteziryayo A, Pontac J, Offiah SA, Angelica A, Oyamienlen CS, Ezeigbo E, Iwuoha K, Chen WC, Walubita E, Lusaka M, Nyangasi M, Mohammed S, Narh CT, Boucheron P, Foerster M, Sch?z J, Dos-Santos-Silva I, McCormack V. Breast cancer overall survival, annual risks of death, and survival gap apportionment in sub-Saharan Africa (ABC-DO): 7-year follow-up of a prospective cohort study. Lancet Glob Health. 2025 Oct; 13(10):e1681-e1690. PMID: 40975077; PMCID: PMC12446903.
      Citations:    Fields:    Translation:Humans
    2. Li JL, Zanti M, Williams J, Jahagirdar O, Jia G, Turcan A, Hu Q, Brandenburg JT, Yan L, Ho WK, Li J, Miranda JP, Godbole D, Dias JA, Zhang X, Dorling L, Chen WC, Boddicker N, Wang Y, Martin A, Zhang YD, Dennis J, John EM, Torres-Mejia G, Kushi L, Weitzel J, Neuhausen SL, Carvajal-Carmona L, Haiman C, Ziv E, Fejerman L, Zheng W, Huo D, Easton D, Chanock SJ, Chatterjee N, Kraft P, Garcia-Closas M, Wong WSW, Michailidou K, Zhu Q, Zhang MJ, Dutta D, Ahearn TU, Zhang H. Genetic and Cellular Architecture of Breast Cancer Risk in Multi-Ancestry Studies of 159,297 Cases and 212,102 Controls. medRxiv. 2025 Aug 25. PMID: 40909829; PMCID: PMC12407622.
      Citations:    
    3. Swiel Y, Brandenburg JT, Hayat M, Chen WC, Cox MA, Hazelhurst S. FPGA acceleration of GWAS permutation testing. Bioinform Adv. 2025; 5(1):vbaf145. PMID: 40630501; PMCID: PMC12237511.
      Citations:    
    4. Almutairi MM, Chen YL, Lee J, Liu Z, Strych U, Hotez PJ, Bottazzi ME, Chen WH. Characteristic profiling of CHO-cell expressed MERS-CoV RBD-Fc. Int J Biol Macromol. 2025 Jun; 311(Pt 2):143678. PMID: 40318720.
      Citations:    Fields:    Translation:HumansAnimalsCells
    5. Brangulis K, Malfetano J, Marcinkiewicz AL, Wang A, Chen YL, Lee J, Liu Z, Yang X, Strych U, Tupina D, Akopjana I, Bottazzi ME, Pal U, Hsieh CL, Chen WH, Lin YP. Mechanistic insights into the structure-based design of a CspZ-targeting Lyme disease vaccine. Nat Commun. 2025 Apr 07; 16(1):2898. PMID: 40189575; PMCID: PMC11973211.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    6. Lykins WR, Pollet J, White JA, Keegan B, Versteeg L, Strych U, Chen WH, Mohamath R, Ramer-Denisoff G, Reed S, Renshaw C, Beaver S, Gerhardt A, Voigt EA, Tomai MA, Sitrin R, Choy RKM, Cassels FJ, Hotez PJ, Bottazzi ME, Fox CB. Optimizing immunogenicity and product presentation of a SARS-CoV-2 subunit vaccine composition: effects of delivery route, heterologous regimens with self-amplifying RNA vaccines, and lyophilization. Front Immunol. 2024; 15:1480976. PMID: 39737197; PMCID: PMC11683073.
      Citations:    Fields:    Translation:HumansAnimalsCells
    7. Motlhale M, Sitas F, de Villiers CB, Simba H, Feliu A, Chen WC, Sch?z J, Muchengeti M, McCormack V. Smokeless tobacco (snuff) and site-specific cancer risks in adult Black South African women: Findings from the Johannesburg Cancer Study. Int J Cancer. 2025 May 15; 156(10):1916-1925. PMID: 39679969.
      Citations: 1     Fields:    Translation:Humans
    8. Dubner J, Neugut AI, Joffe M, O'Neil DS, Ayeni OA, Chen WC, Buccimazza I, Cacala SR, Stopforth LW, Farrow HA, Nietz S, Murugan N, Phakathi B, Jacobson JS, Crew KD, McCormack V, Ruff P, Cubasch H, Pumpalova YS. The association of HIV status with triple-negative breast cancer in patients with breast cancer in South Africa: a cross-sectional analysis of case-only data from a prospective cohort study. Lancet Glob Health. 2024 Dec; 12(12):e1993-e2002. PMID: 39577973; PMCID: PMC11584318.
      Citations:    
    9. Brangulis K, Malfetano J, Marcinkiewicz AL, Wang A, Chen YL, Lee J, Liu Z, Yang X, Strych U, Bottazzi ME, Pal U, Hsieh CL, Chen WH, Lin YP. Mechanistic insights into structure-based design of a Lyme disease subunit vaccine. bioRxiv. 2024 Oct 28. PMID: 39554036; PMCID: PMC11565809.
      Citations:    
    10. Osler TS, Brandenburg JT, Schoeman M, Chen WC, Urban MF, Mathew CG. Prevalence and Reclassification of Genetic Variants in South African Populations with Breast Cancer. Genes Chromosomes Cancer. 2024 Sep; 63(9):e23275. PMID: 39324485.
      Citations:    
    11. Thimmiraju SR, Adhikari R, Redd JR, Villar MJ, Lee J, Liu Z, Chen YL, Sharma S, Kaur A, Uzcategui NL, Ronca SE, Chen WH, Kimata JT, Zhan B, Strych U, Bottazzi ME, Hotez PJ, Pollet J. A trivalent protein-based pan-Betacoronavirus vaccine elicits cross-neutralizing antibodies against a panel of coronavirus pseudoviruses. NPJ Vaccines. 2024 Jul 22; 9(1):132. PMID: 39034332; PMCID: PMC11271464.
      Citations: 1     
    12. van Wyk AC, Lal P, Ogunbiyi JO, Kyokunda L, Hobenu F, Dial C, Jalloh M, Gyasi R, Oluwole OP, Abrahams AD, Botha AR, Mtshali NZ, Andrews C, Mante S, Adusei B, Gueye SM, Mensah JE, Adjei AA, Tettey Y, Adebiyi A, Aisuodionoe-Shadrach O, Eniola SB, Serna A, Yamoah K, Chen WC, Fernandez P, Robinson BD, Mosquera JM, Hsing AW, Agalliu I, Rebbeck TR. Multinational, Multicenter Evaluation of Prostate Cancer Tissue in Sub-Saharan Africa: Challenges and Opportunities. JCO Glob Oncol. 2024 Jun; 10:e2300403. PMID: 38870437; PMCID: PMC11191871.
      Citations:    
    13. Brandenburg JT, Chen WC, Boua PR, Govender MA, Agongo G, Micklesfield LK, Sorgho H, Tollman S, Asiki G, Mashinya F, Hazelhurst S, Morris AP, Fabian J, Ramsay M. Genetic association and transferability for urinary albumin-creatinine ratio as a marker of kidney disease in four Sub-Saharan African populations and non-continental individuals of African ancestry. Front Genet. 2024; 15:1372042. PMID: 38812969; PMCID: PMC11134365.
      Citations:    
    14. Fackler MJ, Pleas M, Li Y, Soni A, Xing D, Cope L, Ali S, Van Le Q, Van Nguyen C, Pham HT, Duong LM, Vanden Berg E, Wadee R, Michelow P, Chen WC, Joffe M, Fjeldbo CS, Lyng H, Sukumar S. Discovery and technical validation of high-performance methylated DNA markers for the detection of cervical lesions at risk of malignant progression in low- and middle-income countries. Clin Epigenetics. 2024 Apr 20; 16(1):56. PMID: 38643219; PMCID: PMC11032610.
      Citations:    
    15. Singini MG, Muchengeti M, Sitas F, Chen WC, Combes JD, Waterboer T, Clifford GM. Antibodies against high-risk human papillomavirus proteins as markers for noncervical HPV-related cancers in a Black South African population, according to HIV status. Int J Cancer. 2024 Jul 15; 155(2):251-260. PMID: 38577820.
      Citations:    
    16. Lykins W, Pollet J, White J, Keegan B, Versteeg L, Strych U, CHEN W-H, Mohamath R, Ramer-Denisoff G, Reed S, Beaver S, Gerhardt A, Voigt E, Tomai M, Sitrin R, Choy R, Cassels F, Hotez PJ, Bottazzi ME, Fox C. Choice of adjuvant and antigen composition alters the immunogenic profile of a SARS-CoV-2 subunit vaccine. Front. Drug Deliv. 2024; 4. View Publication.
    17. Chen YL, Lee J, Liu Z, Strych U, Bottazzi ME, Chen WH, Lin YP. Biophysical and biochemical characterization of a recombinant Lyme disease vaccine antigen, CspZ-YA. Int J Biol Macromol. 2024 Feb; 259(Pt 2):129295. PMID: 38211914.
      Citations:    Fields:    Translation:HumansCells
    18. Pumpalova YS, Ramakrishnan A, May M, Pentz A, Minkowitz S, Doherty S, Singh E, Chen WC, Rebbeck TR, Neugut AI, Joffe M. Biochemical progression free and overall survival among Black men with stage IV prostate cancer in South Africa: Results from a prospective cohort study. Cancer Med. 2024 01; 13(1):e6739. PMID: 38158645; PMCID: PMC10807684.
      Citations:    
    19. Mapanga W, Ayeni OA, Chen WC, Jacobson JS, Neugut AI, Ruff P, Cubasch H, O'Neil DS, Buccimazza I, Cacala S, Stopforth LW, Farrow HA, Nietz S, Phakathi B, Chirwa T, McCormack VA, Joffe M. The South African breast cancer and HIV outcomes study: Profiling the cancer centres and cohort characteristics, diagnostic pathways, and treatment approaches. PLOS Glob Public Health. 2023; 3(10):e0002432. PMID: 37874786; PMCID: PMC10597516.
      Citations:    
    20. O'Neil DS, Ayeni OA, Farrow HA, Chen WC, Demetriou G, Buccimazza I, Cacala S, Stopforth LW, Joffe M, Antoni MH, Lopes G, Pumpalova YS, Mapanga W, Jacobson JS, Crew KD, Neugut AI, Ruff P, Cubasch H. The Impact of HIV Infection on Neoadjuvant and Adjuvant Chemotherapy Relative Dose Intensity in South African Patients with Breast Cancer. Oncologist. 2023 10 03; 28(10):e921-e929. PMID: 36943395; PMCID: PMC10546819.
      Citations:    
    21. Thimmiraju SR, Adhikari R, Villar MJ, Lee J, Liu Z, Kundu R, Chen YL, Sharma S, Ghei K, Keegan B, Versteeg L, Gillespie PM, Ciciriello A, Islam NY, Poveda C, Uzcategui N, Chen WH, Kimata JT, Zhan B, Strych U, Bottazzi ME, Hotez PJ, Pollet J. A Recombinant Protein XBB.1.5 RBD/Alum/CpG Vaccine Elicits High Neutralizing Antibody Titers against Omicron Subvariants of SARS-CoV-2. Vaccines (Basel). 2023 Oct 01; 11(10). PMID: 37896960; PMCID: PMC10610638.
      Citations: 2     
    22. Chen WC, Brandenburg JT, Choudhury A, Hayat M, Sengupta D, Swiel Y, Babb de Villiers C, Ferndale L, Aldous C, Soo CC, Lee S, Curtis C, Newton R, Waterboer T, Sitas F, Bradshaw D, Abnet CC, Ramsay M, Parker MI, Singh E, Lewis CM, Mathew CG. Genome-wide association study of esophageal squamous cell cancer identifies shared and distinct risk variants in African and Chinese populations. Am J Hum Genet. 2023 10 05; 110(10):1690-1703. PMID: 37673066; PMCID: PMC10577073.
      Citations:    
    23. Chiwambutsa SM, Ayeni O, Kapungu N, Kanji C, Thelingwani R, Chen WC, Mokone DH, O'Neil DS, Neugut AI, Jacobson JS, Ruff P, Cubasch H, Joffe M, Masimirembwa C. Effects of Genetic Polymorphisms of Drug Metabolizing Enzymes and co-Medications on Tamoxifen Metabolism in Black South African Women with Breast Cancer. Clin Pharmacol Ther. 2023 07; 114(1):127-136. PMID: 37042388; PMCID: PMC11016593.
      Citations:    
    24. Motlhale M, Muchengeti M, Bradshaw D, Chen WC, Singini MG, de Villiers CB, Lewis CM, Bender N, Mathew CG, Newton R, Waterboer T, Singh E, Sitas F. Kaposi sarcoma-associated herpesvirus, HIV-1 and Kaposi sarcoma risk in black South Africans diagnosed with cancer during antiretroviral treatment rollout. Int J Cancer. 2023 05 15; 152(10):2081-2089. PMID: 36727526.
      Citations:    
    25. Ayeni OA, Jofe M, Mapanga W, Chen WC, O'Neil DS, Phakathi B, Nietz S, Buccimazza I, Cacala S, Stopforth LW, Jacobson JS, Crew KD, Neugut AI, Ramiah D, Ruf P, Cubasch H, Chirwa T, McCormack V, Micklesfeld LK, Norris SA. Correction: Multimorbidity and overall survival among women with breast cancer: results from the South African Breast Cancer and HIV Outcomes Study. Breast Cancer Res. 2023 Jan 31; 25(1):14. PMID: 36721167; PMCID: PMC9890739.
      Citations:    
    26. Ayeni OA, Joffe M, Mapanga W, Chen WC, O'Neil DS, Phakathi B, Nietz S, Buccimazza I, Cacala S, Stopforth LW, Jacobson JS, Crew KD, Neugut AI, Ramiah D, Ruff P, Cubasch H, Chirwa T, McCormack V, Micklesfield LK, Norris SA. Multimorbidity and overall survival among women with breast cancer: results from the South African Breast Cancer and HIV Outcomes Study. Breast Cancer Res. 2023 01 23; 25(1):7. PMID: 36691057; PMCID: PMC9872426.
      Citations:    
    27. Hotez PJ, Adhikari R, Chen WH, Chen YL, Gillespie P, Islam NY, Keegan B, Tyagi Kundu R, Lee J, Liu Z, Kimata JT, Oezguen N, Pollet J, Poveda C, Razavi K, Ronca SE, Strych U, Thimmiraju SR, Versteeg L, Villar-Mondragon MJ, Wei J, Zhan B, Bottazzi ME. From concept to delivery: a yeast-expressed recombinant protein-based COVID-19 vaccine technology suitable for global access. Expert Rev Vaccines. 2023 Jan-Dec; 22(1):495-500. PMID: 37252854.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    28. Ayeni OA, Chiwambutsa S, Chen WC, Kapungu N, Kanji C, Thelingwani R, Murugan N, Mathiba R, Phakathi B, Nietz S, Ramiah D, O'Neil DS, Jacobson JS, Ruff P, Cubasch H, Chirwa T, Joffe M, Masimirembwa C, Neugut AI. The impact of HIV on non-adherence for tamoxifen among women with breast cancer in South Africa. Breast Cancer Res Treat. 2023 Feb; 197(3):647-659. PMID: 36538247; PMCID: PMC10149344.
      Citations:    
    29. Mapanga W, Norris SA, Craig A, Pumpalova Y, Ayeni OA, Chen WC, Jacobson JS, Neugut AI, Muchengeti M, Pentz A, Doherty S, Minkowitz S, Haffejee M, Rebbeck T, Joffe M. Prevalence of multimorbidity in men of African descent with and without prostate cancer in Soweto, South Africa. PLoS One. 2022; 17(10):e0276050. PMID: 36256648; PMCID: PMC9578630.
      Citations:    
    30. Chen WH, Pollet J, Asojo O, Jones KM, Hotez PJ, Elena Bottazzi M, Gonz?lez-L?pez C, Alfaro-Chac?n A, Villanueva-Lizama LE, Rosado-Vallado M, Ramirez-Sierra MJ, Teh-Poot CF, Cruz-Chan JV. A novel multi-epitope recombinant protein elicits an antigen-specific CD8+?T cells response in Trypanosoma cruzi-infected mice. Vaccine. 2022 10 26; 40(45):6445-6449. PMID: 36184402.
      Citations: 1     Fields:    Translation:AnimalsCells
    31. Sengayi-Muchengeti M, Singh E, Chen WC, Bradshaw D, de Villiers CB, Newton R, Waterboer T, Mathew CG, Sitas F. Thirteen cancers associated with HIV infection in a Black South African cancer patient population (1995-2016). Int J Cancer. 2023 01 15; 152(2):183-194. PMID: 36054877.
      Citations:    
    32. Chen WH, Strych U, Bottazzi ME, Lin YP. Past, present, and future of Lyme disease vaccines: antigen engineering approaches and mechanistic insights. Expert Rev Vaccines. 2022 10; 21(10):1405-1417. PMID: 35836340; PMCID: PMC9529901.
      Citations:    Fields:    
    33. Chen YL, Marcinkiewicz AL, Nowak TA, Tyagi Kundu R, Liu Z, Strych U, Bottazzi ME, Chen WH, Lin YP. CspZ FH-Binding Sites as Epitopes Promote Antibody-Mediated Lyme Borreliae Clearance. Infect Immun. 2022 07 21; 90(7):e0006222. PMID: 35861564; PMCID: PMC9302089.
      Citations:    Fields:    Translation:AnimalsCells
    34. Singini MG, Singh E, Bradshaw D, Ramaliba T, Chen WC, Motlhale M, Kamiza AB, Babb de Villiers C, Muchengeti M, Mathew CG, Newton R, Bender N, Waterboer T, Sitas F. Usefulness of high-risk HPV early oncoprotein (E6 and E7) serological markers in the detection of cervical cancer: A systematic review and meta-analysis. J Med Virol. 2023 01; 95(1):e27900. PMID: 35641882; PMCID: PMC10952611.
      Citations:    
    35. Pollet J, Strych U, Chen WH, Versteeg L, Keegan B, Zhan B, Wei J, Liu Z, Lee J, Kundu R, Adhikari R, Poveda C, Jose Villar M, Rani Thimmiraju S, Lopez B, Gillespie PM, Ronca S, Kimata JT, Reers M, Paradkar V, Hotez PJ, Elena Bottazzi M. Receptor-binding domain recombinant protein on alum-CpG induces broad protection against SARS-CoV-2 variants of concern. Vaccine. 2022 06 09; 40(26):3655-3663. PMID: 35568591; PMCID: PMC9080055.
      Citations:    Fields:    Translation:HumansAnimalsCells
    36. Motlhale M, Sitas F, Bradshaw D, Chen WC, Singini MG, de Villiers CB, Lewis CM, Muchengeti M, Waterboer T, Mathew CG, Newton R, Singh E. Epidemiology of Kaposi's sarcoma in sub-Saharan Africa. Cancer Epidemiol. 2022 06; 78:102167. PMID: 35504064.
      Citations:    
    37. Motlhale M, Sitas F, Bradshaw D, Chen WC, Singini MG, de Villiers CB, Lewis CM, Muchengeti M, Waterboer T, Mathew CG, Newton R, Singh E. Lifestyle factors associated with sex differences in Kaposi sarcoma incidence among adult black South Africans: A case-control study. Cancer Epidemiol. 2022 06; 78:102158. PMID: 35421713.
      Citations:    
    38. Muchengeti M, Bartels L, Olago V, Dhokotera T, Chen WC, Spoerri A, Rohner E, B?tikofer L, Ruffieux Y, Singh E, Egger M, Bohlius J. Cohort profile: the South African HIV Cancer Match (SAM) Study, a national population-based cohort. BMJ Open. 2022 04 11; 12(4):e053460. PMID: 35410922; PMCID: PMC9003610.
      Citations:    
    39. Singini MG, Singh E, Bradshaw D, Chen WC, Motlhale M, Kamiza AB, de Villiers CB, Muchengeti M, Mathew CG, Newton R, Bender N, Waterboer T, Sitas F. HPV types 16/18 L1 E6 and E7 proteins seropositivity and cervical cancer risk in HIV-positive and HIV-negative black South African women. Infect Agent Cancer. 2022 Mar 29; 17(1):14. PMID: 35351184; PMCID: PMC8966297.
      Citations:    
    40. Pollet J, Strych U, Chen WH, Versteeg L, Keegan B, Zhan B, Wei J, Liu Z, Lee J, Kundu R, Adhikari R, Poveda C, Villar MJ, Thimmiraju SR, Lopez B, Gillespie PM, Ronca S, Kimata JT, Reers M, Paradkar V, Hotez P, Bottazzi ME. Receptor-binding domain recombinant protein on alum-CpG induces broad protection against SARS-CoV-2 variants of concern. bioRxiv. 2022 Mar 22. PMID: 34268512; PMCID: PMC8282101.
      Citations: 1     
    41. Pumpalova YS, Ayeni OA, Chen WC, Buccimazza I, Cacala S, Stopforth LW, Farrow HA, Mapanga W, Nietz S, Phakathi B, Joffe M, McCormack V, Jacobson JS, Crew KD, Neugut AI, Ruff P, Cubasch H, O'Neil DS. The Impact of Breast Cancer Treatment Delays on Survival Among South African Women. Oncologist. 2022 03 11; 27(3):e233-e243. PMID: 35274708; PMCID: PMC8914482.
      Citations:    
    42. Ayeni OA, O'Neil DS, Pumpalova YS, Chen WC, Nietz S, Phakathi B, Buccimazza I, Cacala S, Stopforth LW, Farrow HA, Mapanga W, Joffe M, Chirwa T, McCormack V, Jacobson JS, Crew KD, Neugut AI, Ruff P, Cubasch H. Impact of HIV infection on survival among women with stage I-III breast cancer: Results from the South African breast cancer and HIV outcomes study. Int J Cancer. 2022 07 15; 151(2):209-221. PMID: 35218568; PMCID: PMC9133061.
      Citations:    
    43. Singini MG, Sitas F, Bradshaw D, Chen WC, Motlhale M, Kamiza AB, de Villiers CB, Lewis CM, Mathew CG, Waterboer T, Newton R, Muchengeti M, Singh E. Ranking lifestyle risk factors for cervical cancer among Black women: A case-control study from Johannesburg, South Africa. PLoS One. 2021; 16(12):e0260319. PMID: 34879064; PMCID: PMC8654217.
      Citations:    
    44. Agalliu I, Lin WJ, Zhang JS, Jacobson JS, Rohan TE, Adusei B, Snyper NYF, Andrews C, Sidahmed E, Mensah JE, Biritwum R, Adjei AA, Okyne V, Ainuson-Quampah J, Fernandez P, Irusen H, Odiaka E, Folasire OF, Ifeoluwa MG, Aisuodionoe-Shadrach OI, Nwegbu MM, Pentz A, Chen WC, Joffe M, Neugut AI, Diallo TA, Jalloh M, Rebbeck TR, Adebiyi AO, Hsing AW. Overall and central obesity and prostate cancer risk in African men. Cancer Causes Control. 2022 Feb; 33(2):223-239. PMID: 34783926; PMCID: PMC8776598.
      Citations:    
    45. Chen WH, Pollet J, Strych U, Lee J, Liu Z, Kundu RT, Versteeg L, Villar MJ, Adhikari R, Wei J, Poveda C, Keegan B, Bailey AO, Chen YL, Gillespie PM, Kimata JT, Zhan B, Hotez PJ, Bottazzi ME. Yeast-expressed recombinant SARS-CoV-2 receptor binding domain RBD203-N1 as a COVID-19 protein vaccine candidate. Protein Expr Purif. 2022 02; 190:106003. PMID: 34688919; PMCID: PMC8529586.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    46. Hayat M, Chen WC, Brandenburg JT, Babb de Villiers C, Ramsay M, Mathew CG. Genetic Susceptibility to Breast Cancer in Sub-Saharan African Populations. JCO Glob Oncol. 2021 09; 7:1462-1471. PMID: 34623906; PMCID: PMC8509920.
      Citations:    
    47. Pino M, Abid T, Pereira Ribeiro S, Edara VV, Floyd K, Smith JC, Latif MB, Pacheco-Sanchez G, Dutta D, Wang S, Gumber S, Kirejczyk S, Cohen J, Stammen RL, Jean SM, Wood JS, Connor-Stroud F, Pollet J, Chen WH, Wei J, Zhan B, Lee J, Liu Z, Strych U, Shenvi N, Easley K, Weiskopf D, Sette A, Pollara J, Mielke D, Gao H, Eisel N, LaBranche CC, Shen X, Ferrari G, Tomaras GD, Montefiori DC, Sekaly RP, Vanderford TH, Tomai MA, Fox CB, Suthar MS, Kozlowski PA, Hotez PJ, Paiardini M, Bottazzi ME, Kasturi SP. A yeast expressed RBD-based SARS-CoV-2 vaccine formulated with 3M-052-alum adjuvant promotes protective efficacy in non-human primates. Sci Immunol. 2021 07 15; 6(61). PMID: 34266981; PMCID: PMC9119307.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    48. Pumpalova YS, Ayeni OA, Chen WC, O'Neil DS, Nietz S, Phakathi B, Buccimazza I, Cacala S, Stopforth LW, Farrow HA, Joffe M, Mapanga W, Jacobson JS, Crew KD, Cubasch H, Ruff P, Neugut AI. Impact of HIV infection on overall survival among women with stage IV breast cancer in South Africa. Breast Cancer Res Treat. 2021 Aug; 189(1):285-296. PMID: 34125339; PMCID: PMC9034410.
      Citations:    
    49. Lee J, Liu Z, Chen WH, Wei J, Kundu R, Adhikari R, Rivera JA, Gillespie PM, Strych U, Zhan B, Hotez PJ, Bottazzi ME. Process development and scale-up optimization of the SARS-CoV-2 receptor binding domain-based vaccine candidate, RBD219-N1C1. Appl Microbiol Biotechnol. 2021 May; 105(10):4153-4165. PMID: 33959781; PMCID: PMC8102132.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    50. Pollet J, Chen WH, Versteeg L, Keegan B, Zhan B, Wei J, Liu Z, Lee J, Kundu R, Adhikari R, Poveda C, Villar MJ, de Araujo Leao AC, Altieri Rivera J, Momin Z, Gillespie PM, Kimata JT, Strych U, Hotez PJ, Bottazzi ME. SARS-CoV-2 RBD219-N1C1: A yeast-expressed SARS-CoV-2 recombinant receptor-binding domain candidate vaccine stimulates virus neutralizing antibodies and T-cell immunity in mice. Hum Vaccin Immunother. 2021 08 03; 17(8):2356-2366. PMID: 33847226; PMCID: PMC8054496.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    51. Chen WH, Wei J, Kundu RT, Adhikari R, Liu Z, Lee J, Versteeg L, Poveda C, Keegan B, Villar MJ, de Araujo Leao AC, Rivera JA, Gillespie PM, Pollet J, Strych U, Zhan B, Hotez PJ, Bottazzi ME. Genetic modification to design a stable yeast-expressed recombinant SARS-CoV-2 receptor binding domain as a COVID-19 vaccine candidate. Biochim Biophys Acta Gen Subj. 2021 06; 1865(6):129893. PMID: 33731300; PMCID: PMC7955913.
      Citations: 10     Fields:    Translation:AnimalsCells
    52. Pollet J, Chen WH, Versteeg L, Keegan B, Zhan B, Wei J, Liu Z, Lee J, Kundu R, Adhikari R, Poveda C, Villar MJ, de Araujo Leao AC, Rivera JA, Momin Z, Gillespie PM, Kimata JT, Strych U, Hotez PJ, Bottazzi ME. SARS-CoV-2 RBD219-N1C1: A Yeast-Expressed SARS-CoV-2 Recombinant Receptor-Binding Domain Candidate Vaccine Stimulates Virus Neutralizing Antibodies and T-cell Immunity in Mice. bioRxiv. 2021 Feb 09. PMID: 33173864; PMCID: PMC7654852.
      Citations: 3     
    53. Motsuku L, Chen WC, Muchengeti MM, Naidoo M, Quene TM, Kellett P, Mohlala MI, Chu KM, Singh E. Colorectal cancer incidence and mortality trends by sex and population group in South Africa: 2002-2014. BMC Cancer. 2021 Feb 06; 21(1):129. PMID: 33549058; PMCID: PMC7866437.
      Citations:    
    54. Pollet J, Chen WH, Strych U. Recombinant protein vaccines, a proven approach against coronavirus pandemics. Adv Drug Deliv Rev. 2021 03; 170:71-82. PMID: 33421475; PMCID: PMC7788321.
      Citations: 33     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    55. Nietz S, Ruff P, Chen WC, O'Neil DS, Norris SA. Quality indicators for the diagnosis and surgical management of breast cancer in South Africa. Breast. 2020 Dec; 54:187-196. PMID: 33120084; PMCID: PMC7593621.
      Citations:    
    56. Chen WH, Tao X, Agrawal AS, Algaissi A, Peng BH, Pollet J, Strych U, Bottazzi ME, Hotez PJ, Lustigman S, Du L, Jiang S, Tseng CK. Yeast-expressed SARS-CoV recombinant receptor-binding domain (RBD219-N1) formulated with aluminum hydroxide induces protective immunity and reduces immune enhancement. Vaccine. 2020 11 03; 38(47):7533-7541. PMID: 33039209; PMCID: PMC7508514.
      Citations: 38     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    57. Liu Z, Kundu R, Biter AB, Nyon MP, Chen WH, Zhan B, Strych U, Hotez PJ, Bottazzi ME, Damena S. A scalable and reproducible manufacturing process for Phlebotomus papatasi salivary protein PpSP15, a vaccine candidate for leishmaniasis. Protein Expr Purif. 2021 01; 177:105750. PMID: 32920041.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    58. Nietz S, O'Neil DS, Ayeni O, Chen WC, Joffe M, Jacobson JS, Neugut AI, Ruff P, Mapanga W, Buccimazza I, Singh U, Cacala S, Stopforth L, Phakathi B, Chirwa T, Cubasch H. A comparison of complete pathologic response rates following neoadjuvant chemotherapy among South African breast cancer patients with and without concurrent HIV infection. Breast Cancer Res Treat. 2020 Dec; 184(3):861-872. PMID: 32875480; PMCID: PMC7658037.
      Citations:    
    59. Chen WH, Tao X, Agrawal A, Algaissi A, Peng BH, Pollet J, Strych U, Bottazzi ME, Hotez PJ, Lustigman S, Du L, Jiang S, Tseng CK. Yeast-Expressed SARS-CoV Recombinant Receptor-Binding Domain (RBD219-N1) Formulated with Aluminum Hydroxide Induces Protective Immunity and Reduces Immune Enhancement. bioRxiv. 2020 Jul 05. PMID: 32511385; PMCID: PMC7263514.
      Citations:    
    60. Marcinkiewicz AL, Lieknina I, Yang X, Lederman PL, Hart TM, Yates J, Chen WH, Bottazzi ME, Mantis NJ, Kraiczy P, Pal U, Tars K, Lin YP. The Factor H-Binding Site of CspZ as a Protective Target against Multistrain, Tick-Transmitted Lyme Disease. Infect Immun. 2020 04 20; 88(5). PMID: 32122944; PMCID: PMC7171238.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    61. Chen WH, Hotez PJ, Bottazzi ME. Potential for developing a SARS-CoV receptor-binding domain (RBD) recombinant protein as a heterologous human vaccine against coronavirus infectious disease (COVID)-19. Hum Vaccin Immunother. 2020 06 02; 16(6):1239-1242. PMID: 32298218; PMCID: PMC7482854.
      Citations: 53     Fields:    Translation:HumansCellsPHPublic Health
    62. Chen WC, Singh E, Muchengeti M, Bradshaw D, Mathew CG, Babb de Villiers C, Lewis CM, Waterboer T, Newton R, Sitas F. Johannesburg Cancer Study (JCS): contribution to knowledge and opportunities arising from 20 years of data collection in an African setting. Cancer Epidemiol. 2020 04; 65:101701. PMID: 32169796.
      Citations:    
    63. Chen WH, Strych U, Hotez PJ, Bottazzi ME. The SARS-CoV-2 Vaccine Pipeline: an Overview. Curr Trop Med Rep. 2020; 7(2):61-64. PMID: 32219057; PMCID: PMC7094941.
      Citations: 215     
    64. Chen WH, Nyon MP, Poongavanam MV, Liu Z, Biter AB, Kundu RT, Strych U, Hotez PJ, Bottazzi ME. Process Characterization and Biophysical Analysis for a Yeast-Expressed Phlebotomus papatasi Salivary Protein (PpSP15) as?a Leishmania Vaccine Candidate. J Pharm Sci. 2020 05; 109(5):1673-1680. PMID: 32070701; PMCID: PMC7125844.
      Citations: 1     Fields:    Translation:Animals
    65. Biter AB, Pollet J, Chen WH, Strych U, Hotez PJ, Bottazzi ME. A method to probe protein structure from UV absorbance spectra. Anal Biochem. 2019 12 15; 587:113450. PMID: 31550438.
      Citations:    Fields:    Translation:Cells
    66. Chen WC, Kerr R, May A, Ndlovu B, Sobalisa A, Duze ST, Joseph L, Mathew CG, Babb de Villiers C. The Integrity and Yield of Genomic DNA Isolated from Whole Blood Following Long-Term Storage at -30?C. Biopreserv Biobank. 2018 Apr; 16(2):106-113. PMID: 29298092.
      Citations:    
    67. Biter AB, Weltje S, Hudspeth EM, Seid CA, McAtee CP, Chen WH, Pollet JB, Strych U, Hotez PJ, Bottazzi ME. Characterization and Stability of Trypanosoma cruzi 24-C4 (Tc24-C4), a Candidate Antigen for a Therapeutic Vaccine Against Chagas Disease. J Pharm Sci. 2018 05; 107(5):1468-1473. PMID: 29274820.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    68. Chen WH, Chag SM, Poongavanam MV, Biter AB, Ewere EA, Rezende W, Seid CA, Hudspeth EM, Pollet J, McAtee CP, Strych U, Bottazzi ME, Hotez PJ. Optimization of the Production Process and Characterization of the Yeast-Expressed SARS-CoV Recombinant Receptor-Binding Domain (RBD219-N1), a SARS Vaccine Candidate. J Pharm Sci. 2017 08; 106(8):1961-1970. PMID: 28456726; PMCID: PMC5612335.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    69. Hotez PJ, Bottazzi ME, Zhan B, CHEN W-H, Chag S . A novel SARS immunogenic composition. 2016. View Publication.
    70. Kisley L, Chen J, Mansur AP, Shuang B, Kourentzi K, Poongavanam MV, Chen WH, Dhamane S, Willson RC, Landes CF. Unified superresolution experiments and stochastic theory provide mechanistic insight into protein ion-exchange adsorptive separations. Proc Natl Acad Sci U S A. 2014 Feb 11; 111(6):2075-80. PMID: 24459184; PMCID: PMC3926075.
      Citations: 11     Fields:    Translation:Cells
    71. Chen WH, Du L, Chag SM, Ma C, Tricoche N, Tao X, Seid CA, Hudspeth EM, Lustigman S, Tseng CT, Bottazzi ME, Hotez PJ, Zhan B, Jiang S. Yeast-expressed recombinant protein of the receptor-binding domain in SARS-CoV spike protein with deglycosylated forms as a SARS vaccine candidate. Hum Vaccin Immunother. 2014; 10(3):648-58. PMID: 24355931; PMCID: PMC4130269.
      Citations: 57     Fields:    Translation:AnimalsCells
    72. Dhamane S, Chen WH, Kourentzi K, Ruiz-Ruiz F, Benavides J, Rito-Palomares M, Willson RC. Spermine Sepharose as a clustered-charge anion exchange adsorbent. J Chromatogr A. 2014 Jan 10; 1324:135-40. PMID: 24296294.
      Citations:    Fields:    Translation:AnimalsCells
    73. Adhikari M, Dhamane S, Garvey G, Chen WH, Kourentzi K, Strych U, Willson RC, Hagstr?m AE. Functionalized viral nanoparticles as ultrasensitive reporters in lateral-flow assays. Analyst. 2013 Oct 07; 138(19):5584-7. PMID: 23905160.
      Citations: 10     Fields:    Translation:HumansCells
    74. Kanakaraj I, Chen WH, Poongavanam M, Dhamane S, Stagg LJ, Ladbury JE, Kourentzi K, Strych U, Willson RC. Biophysical characterization of VEGF-aHt DNA aptamer interactions. Int J Biol Macromol. 2013 Jun; 57:69-75. PMID: 23470436.
      Citations: 2     Fields:    Translation:HumansAnimals
    75. Daniels CR, Kisley L, Kim H, Chen WH, Poongavanam MV, Reznik C, Kourentzi K, Willson RC, Landes CF. Fluorescence correlation spectroscopy study of protein transport and dynamic interactions with clustered-charge peptide adsorbents. J Mol Recognit. 2012 Aug; 25(8):435-42. PMID: 22811068; PMCID: PMC3671587.
      Citations: 4     Fields:    Translation:Cells
    76. Daniels CR, Reznik C, Kilmer R, Felipe MJ, Tria MC, Kourentzi K, Chen WH, Advincula RC, Willson RC, Landes CF. Permeability of anti-fouling PEGylated surfaces probed by fluorescence correlation spectroscopy. Colloids Surf B Biointerfaces. 2011 Nov 01; 88(1):31-8. PMID: 21742471; PMCID: PMC5625349.
      Citations: 5     Fields:    
    77. Chen WH, Fu JY, Kourentzi K, Willson RC. Nucleic acid affinity of clustered-charge anion exchange adsorbents: effects of ionic strength and ligand density. J Chromatogr A. 2011 Jan 14; 1218(2):258-62. PMID: 21159348.
      Citations: 4     Fields:    Translation:AnimalsCells
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