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MITCHELL FREDERICK

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Otolaryngology-Head and Neck Surgery
Address6501 Fannin St
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Radiation Oncology
    DivisionRadiation Oncology


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    R01DE030104     (OSMAN, ABDULLAH ALI)Jul 1, 2021 - Apr 30, 2026
    NIH
    Targeting replication stress and homologous recombination repair mechanisms in HPV-positive and negative head and neck cancer
    Role: Co-Principal Investigator
    R01CA235620     (JOHNSON, FAYE)Sep 18, 2019 - Aug 31, 2024
    NIH
    Targeting Alterations of the NOTCH1 Pathway in Head & Neck Squamous Cell Carcinoma (HNSCC)
    Role: Co-Principal Investigator
    U01DE025181     (MYERS, JEFFREY NICHOLAS)Jul 1, 2015 - Apr 30, 2021
    NIH
    Translating genomic alterations into novel therapeutic targets in head and neck cancer through computational and functional approaches
    Role: Co-Principal Investigator
    R01DE024179     (FREDERICK, MITCHELL J)Jan 1, 2015 - Dec 31, 2019
    NIH
    Mechanisms and Consequences of NOTCH Dysfunction in Head and Neck Cancer
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Patel R, Saab K, Luo L, Ma Y, Osman RA, Williams NT, Everitt J, Zelazowski MJ, Castro P, Decker WK, Hudson WH, Myers JN, Sandulache VC, Frederick MJ, Mowery YM, Kirsch DG, Patel R, Saab K, Luo L, Ma Y, Osman RA, Williams NT, Everitt J, Zelazowski MJ, Castro P, Decker WK, Hudson WH, Myers JN, Sandulache VC, Frederick MJ, Mowery YM, Kirsch DG. Nrf2 Hyperactivation as a Driver of Radiotherapy Resistance and Suppressed Antitumor Immunity in Head and Neck Squamous Cell Carcinoma. Clin Cancer Res. 2025 Oct 01; 31(19):4184-4195. PMID: 40742317; PMCID: PMC12428276.
      Citations:    Fields:    
    2. Kawabe M, Yang S, Bolanos LG, Takamatsu S, Flores S, Castro PD, Tsai TY, Nishikawa-Kaga A, Frederick MJ, Sandulache V, Kadara H, Myers JN, Osman AA. Targeted suppression of SPP1 inhibits tumor invasion and metastasis in NRF2 hyperactivated cisplatin resistant HNSCC. bioRxiv. 2025 Jun 01. PMID: 40501947; PMCID: PMC12154876.
      Citations:    
    3. Shah PA, Mazumdar T, Ghosh S, Yapindi L, Powell RT, Park YS, Shen L, Fernandez AM, Stephan CC, Wang J, Sikora AG, Kazi J, Frederick MJ, Johnson FM. Polo-like kinase 1 inactivation enhances PI3K inhibition-mediated apoptosis of NOTCH1-mutant head and neck squamous cell carcinoma. Cancer Lett. 2025 Aug 10; 625:217814. PMID: 40412794.
      Citations:    Fields:    Translation:HumansAnimalsCells
    4. Frederick MJ, Perez-Bello D, Yadollahi P, Castro P, Frederick A, Frederick A, Osman RA, Essien F, Yebra I, Hamlin A, Ow TJ, Skinner HD, Sandulache VC. Reliable RNA-seq analysis from FFPE specimens as a means to accelerate cancer-related health disparities research. PLoS One. 2025; 20(4):e0321631. PMID: 40258023; PMCID: PMC12011225.
      Citations:    Fields:    Translation:Humans
    5. Li Y, Yadollahi P, Essien FN, Putluri V, Ambati CSR, Kami Reddy KR, Kamal AHM, Putluri N, Abdurrahman LM, Ruiz Echartea ME, Ernste KJ, Trivedi AJ, Vazquez-Perez J, Hudson WH, Decker WK, Patel R, Osman AA, Kheradmand F, Lai SY, Myers JN, Skinner HD, Coarfa C, Lee K, Jain A, Malovannaya A, Frederick MJ, Sandulache VC. Tobacco smoke exposure is a driver of altered oxidative stress response and immunity in head and neck cancer. J Transl Med. 2025 Apr 05; 23(1):403. PMID: 40188338; PMCID: PMC11971752.
      Citations: 1     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    6. Michikawa C, Gleber-Netto FO, Pickering CR, Rao X, Wang J, Sikora AG, Myers JN, Frederick MJ. Immune infiltration at the primary tumor is associated with clinical outcome of patients with extranodal extension of lymph node metastasis in oral cancer. Oral Oncol. 2024 Jun; 153:106729. PMID: 38663156; PMCID: PMC12276890.
      Citations:    Fields:    Translation:Humans
    7. Pifer PM, Yang L, Kumar M, Xie T, Frederick M, Hefner A, Beadle B, Molkentine D, Molkentine J, Dhawan A, Abdelhakiem M, Osman AA, Leibowitz BJ, Myers JN, Pickering CR, Sandulache VC, Heymach J, Skinner HD. FAK Drives Resistance to Therapy in HPV-Negative Head and Neck Cancer in a p53-Dependent Manner. Clin Cancer Res. 2024 01 05; 30(1):187-197. PMID: 37819945; PMCID: PMC10767302.
      Citations: 3     Fields:    
    8. Castro P, Corredor G, Koyuncu C, Nordstrom LA, Tiji M, Leavitt T, Lewis JS, Madabhushi A, Frederick MJ, Sandulache VC. Recurrent Oropharyngeal Squamous Cell Carcinomas Maintain Anti-tumor Immunity and Multinucleation Levels Following Completion of Radiation. Head Neck Pathol. 2023 Dec; 17(4):952-960. PMID: 37995073; PMCID: PMC10739687.
      Citations:    Fields:    Translation:HumansCells
    9. Castro P, Corredor G, Koyuncu C, Nordstrom LA, Tiji M, Leavitt T, Lewis JS, Madabhushi A, Frederick MJ, Sandulache VC. Recurrent oropharyngeal squamous cell carcinomas maintain anti-tumor immunity and multinucleation levels following completion of radiation. Res Sq. 2023 Aug 21. PMID: 37674722; PMCID: PMC10479446.
      Citations:    
    10. Koyuncu CF, Frederick MJ, Thompson LDR, Corredor G, Khalighi S, Zhang Z, Song B, Lu C, Nag R, Sankar Viswanathan V, Gilkey M, Yang K, Koyfman SA, Chute DJ, Castro P, Lewis JS, Madabhushi A, Sandulache VC. Machine learning driven index of tumor multinucleation correlates with survival and suppressed anti-tumor immunity in head and neck squamous cell carcinoma patients. Oral Oncol. 2023 08; 143:106459. PMID: 37307602; PMCID: PMC10330801.
      Citations: 2     Fields:    Translation:Humans
    11. Osman AA, Arslan E, Bartels M, Michikawa C, Lindemann A, Tomczak K, Yu W, Sandulache V, Ma W, Shen L, Wang J, Singh AK, Frederick MJ, Spencer ND, Kovacs J, Heffernan T, Symmans WF, Rai K, Myers JN. Dysregulation and Epigenetic Reprogramming of NRF2 Signaling Axis Promote Acquisition of Cisplatin Resistance and Metastasis in Head and Neck Squamous Cell Carcinoma. Clin Cancer Res. 2023 04 03; 29(7):1344-1359. PMID: 36689560; PMCID: PMC10068451.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    12. Yu W, Chen Y, Putluri N, Osman A, Coarfa C, Putluri V, Kamal AHM, Asmussen JK, Katsonis P, Myers JN, Lai SY, Lu W, Stephan CC, Powell RT, Johnson FM, Skinner HD, Kazi J, Ahmed KM, Hu L, Threet A, Meyer MD, Bankson JA, Wang T, Davis J, Parker KR, Harris MA, Baek ML, Echeverria GV, Qi X, Wang J, Frederick AI, Walsh AJ, Lichtarge O, Frederick MJ, Sandulache VC. Evolution of cisplatin resistance through coordinated metabolic reprogramming of the cellular reductive state. Br J Cancer. 2023 06; 128(11):2013-2024. PMID: 37012319; PMCID: PMC10205814.
      Citations: 1     Fields:    Translation:HumansCells
    13. Johnson FM, Janku F, Gouda MA, Tran HT, Kawedia JD, Schmitz D, Streefkerk H, Lee JJ, Andersen CR, Deng D, Rawal S, Shah PA, El-Naggar AK, Johnson JM, Frederick MJ. Inhibition of the Phosphatidylinositol-3 Kinase Pathway Using Bimiralisib in Loss-of-Function NOTCH1-Mutant Head and Neck Cancer. Oncologist. 2022 12 09; 27(12):1004-e926. PMID: 36124629; PMCID: PMC9732253.
      Citations:    
    14. Shah PA, Sambandam V, Fernandez AM, Zhao H, Mazumdar T, Shen L, Wang Q, Ahmed KM, Ghosh S, Frederick MJ, Wang J, Johnson FM. Sustained Aurora Kinase B Expression Confers Resistance to PI3K Inhibition in Head and Neck Squamous Cell Carcinoma. Cancer Res. 2022 12 02; 82(23):4444-4456. PMID: 36169922; PMCID: PMC9722567.
      Citations: 1     Fields:    Translation:HumansCells
    15. Ghosh S, Mazumdar T, Xu W, Powell RT, Stephan C, Shen L, Shah PA, Pickering CR, Myers JN, Wang J, Frederick MJ, Johnson FM. Combined TRIP13 and Aurora Kinase Inhibition Induces Apoptosis in Human Papillomavirus-Driven Cancers. Clin Cancer Res. 2022 10 14; 28(20):4479-4493. PMID: 35972731; PMCID: PMC9588713.
      Citations:    
    16. Ahmed KM, Veeramachaneni R, Deng D, Putluri N, Putluri V, Cardenas MF, Wheeler DA, Decker WK, Frederick AI, Kazi S, Sikora AG, Sandulache VC, Frederick MJ. Glutathione peroxidase 2 is a metabolic driver of the tumor immune microenvironment and immune checkpoint inhibitor response. J Immunother Cancer. 2022 08; 10(8). PMID: 36002187; PMCID: PMC9413193.
      Citations:    
    17. Hsu TK, Asmussen J, Koire A, Choi BK, Gadhikar MA, Huh E, Lin CH, Konecki DM, Kim YW, Pickering CR, Kimmel M, Donehower LA, Frederick MJ, Myers JN, Katsonis P, Lichtarge O. A general calculus of fitness landscapes finds genes under selection in cancers. Genome Res. 2022 05; 32(5):916-929. PMID: 35301263; PMCID: PMC9104707.
      Citations: 2     Fields:    Translation:Humans
    18. Wilde DC, Castro PD, Bera K, Lai S, Madabhushi A, Corredor G, Koyuncu C, Lewis JS, Lu C, Frederick MJ, Frederick AM, Haugen AE, Zevallos JP, Sturgis EM, Shi J, Huang AT, Hernandez DJ, Skinner HD, Kemnade JO, Yu W, Sikora AG, Sandulache VC. Oropharyngeal cancer outcomes correlate with p16 status, multinucleation and immune infiltration. Mod Pathol. 2022 08; 35(8):1045-1054. PMID: 35184149; PMCID: PMC10391519.
      Citations:    Fields:    Translation:HumansCells
    19. Kumar M, Molkentine D, Molkentine J, Bridges K, Xie T, Yang L, Hefner A, Gao M, Bahri R, Dhawan A, Frederick MJ, Seth S, Abdelhakiem M, Beadle BM, Johnson F, Wang J, Shen L, Heffernan T, Sheth A, Ferris RL, Myers JN, Pickering CR, Skinner HD. Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function. Nat Commun. 2021 11 03; 12(1):6340. PMID: 34732714; PMCID: PMC8566594.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    20. Spiotto MT, Taniguchi CM, Klopp AH, Colbert LE, Lin SH, Wang L, Frederick MJ, Osman AA, Pickering CR, Frank SJ. Biology of the Radio- and Chemo-Responsiveness in HPV Malignancies. Semin Radiat Oncol. 2021 10; 31(4):274-285. PMID: 34455983; PMCID: PMC8689584.
      Citations: 1     Fields:    Translation:HumansCells
    21. Lindemann A, Patel AA, Tang L, Tanaka N, Gleber-Netto FO, Bartels MD, Wang L, McGrail DJ, Lin SY, Frank SJ, Frederick MJ, Myers JN, Osman AA. Combined Inhibition of Rad51 and Wee1 Enhances Cell Killing in HNSCC Through Induction of Apoptosis Associated With Excessive DNA Damage and Replication Stress. Mol Cancer Ther. 2021 07; 20(7):1257-1269. PMID: 33947685; PMCID: PMC8295235.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    22. Shah PA, Huang C, Li Q, Kazi SA, Byers LA, Wang J, Johnson FM, Frederick MJ. NOTCH1 Signaling in Head and Neck Squamous Cell Carcinoma. Cells. 2020 12 12; 9(12). PMID: 33322834; PMCID: PMC7764697.
      Citations: 7     Fields:    Translation:HumansCells
    23. Frederick M, Skinner HD, Kazi SA, Sikora AG, Sandulache VC. High expression of oxidative phosphorylation genes predicts improved survival in squamous cell carcinomas of the head and neck and lung. Sci Rep. 2020 04 14; 10(1):6380. PMID: 32286489; PMCID: PMC7156383.
      Citations: 3     Fields:    Translation:HumansCells
    24. Molkentine JM, Molkentine DP, Bridges KA, Xie T, Yang L, Sheth A, Heffernan TP, Clump DA, Faust AZ, Ferris RL, Myers JN, Frederick MJ, Mason KA, Meyn RE, Pickering CR, Skinner HD. Targeting DNA damage response in head and neck cancers through abrogation of cell cycle checkpoints. Int J Radiat Biol. 2021; 97(8):1121-1128. PMID: 32073931; PMCID: PMC7483862.
      Citations: 17     Fields:    Translation:HumansCells
    25. Sambandam V, Frederick MJ, Shen L, Tong P, Rao X, Peng S, Singh R, Mazumdar T, Huang C, Li Q, Pickering CR, Myers JN, Wang J, Johnson FM. PDK1 Mediates NOTCH1-Mutated Head and Neck Squamous Carcinoma Vulnerability to Therapeutic PI3K/mTOR Inhibition. Clin Cancer Res. 2019 06 01; 25(11):3329-3340. PMID: 30770351; PMCID: PMC6548600.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    26. Gadhikar MA, Zhang J, Shen L, Rao X, Wang J, Zhao M, Kalu NN, Johnson FM, Byers LA, Heymach J, Hittelman WN, Udayakumar D, Pandita RK, Pandita TK, Pickering CR, Redwood AB, Piwnica-Worms H, Schlacher K, Frederick MJ, Myers JN. CDKN2A/p16 Deletion in Head and Neck Cancer Cells Is Associated with CDK2 Activation, Replication Stress, and Vulnerability to CHK1 Inhibition. Cancer Res. 2018 02 01; 78(3):781-797. PMID: 29229598; PMCID: PMC5811346.
      Citations: 21     Fields:    Translation:HumansCells
    27. Kalu NN, Mazumdar T, Peng S, Shen L, Sambandam V, Rao X, Xi Y, Li L, Qi Y, Gleber-Netto FO, Patel A, Wang J, Frederick MJ, Myers JN, Pickering CR, Johnson FM. Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines. Oncotarget. 2017 Oct 17; 8(49):86369-86383. PMID: 29156801; PMCID: PMC5689691.
      Citations: 18     Fields:    
    28. Tanaka N, Patel AA, Tang L, Silver NL, Lindemann A, Takahashi H, Jaksik R, Rao X, Kalu NN, Chen TC, Wang J, Frederick MJ, Johnson F, Gleber-Netto FO, Fu S, Kimmel M, Wang J, Hittelman WN, Pickering CR, Myers JN, Osman AA. Replication Stress Leading to Apoptosis within the S-phase Contributes to Synergism between Vorinostat and AZD1775 in HNSCC Harboring High-Risk TP53 Mutation. Clin Cancer Res. 2017 Nov 01; 23(21):6541-6554. PMID: 28790110; PMCID: PMC5724758.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    29. Zhang M, Singh R, Peng S, Mazumdar T, Sambandam V, Shen L, Tong P, Li L, Kalu NN, Pickering CR, Frederick M, Myers JN, Wang J, Johnson FM. Mutations of the LIM protein AJUBA mediate sensitivity of head and neck squamous cell carcinoma to treatment with cell-cycle inhibitors. Cancer Lett. 2017 04 28; 392:71-82. PMID: 28126323; PMCID: PMC5404895.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    30. Chitsazzadeh V, Coarfa C, Drummond JA, Nguyen T, Joseph A, Chilukuri S, Charpiot E, Adelmann CH, Ching G, Nguyen TN, Nicholas C, Thomas VD, Migden M, MacFarlane D, Thompson E, Shen J, Takata Y, McNiece K, Polansky MA, Abbas HA, Rajapakshe K, Gower A, Spira A, Covington KR, Xiao W, Gunaratne P, Pickering C, Frederick M, Myers JN, Shen L, Yao H, Su X, Rapini RP, Wheeler DA, Hawk ET, Flores ER, Tsai KY. Cross-species identification of genomic drivers of squamous cell carcinoma development across preneoplastic intermediates. Nat Commun. 2016 08 30; 7:12601. PMID: 27574101; PMCID: PMC5013636.
      Citations: 50     Fields:    Translation:HumansAnimals
    31. Pickering CR, Papadimitrakopoulou VA, Jelinek J, Lin SH, William WN, Frederick MJ, Wang J, Lang W, Feng L, Zhang L, Kim ES, Fan YH, Hong WK, El-Naggar AK, Lee JJ, Myers JN, Issa JP, Lippman SM, Mao L, Foy JP, Saintigny P. New DNA methylation markers and global DNA hypomethylation are associated with oral cancer development. Cancer Prev Res (Phila). 2015 Nov; 8(11):1027-35. PMID: 26342026; PMCID: PMC4777304.
      Citations: 27     Fields:    Translation:HumansCells
    32. Tanaka N, Patel AA, Wang J, Frederick MJ, Kalu NN, Zhao M, Fitzgerald AL, Xie TX, Silver NL, Caulin C, Zhou G, Skinner HD, Johnson FM, Myers JN, Osman AA. Wee-1 Kinase Inhibition Sensitizes High-Risk HPV+ HNSCC to Apoptosis Accompanied by Downregulation of MCl-1 and XIAP Antiapoptotic Proteins. Clin Cancer Res. 2015 Nov 01; 21(21):4831-44. PMID: 26124202; PMCID: PMC4631620.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    33. Rivera LB, Meyronet D, Hervieu V, Frederick MJ, Bergsland E, Bergers G, Meyronet D, Hervieu V, Frederick MJ. Intratumoral myeloid cells regulate responsiveness and resistance to antiangiogenic therapy. Cell Rep. 2015 Apr 28; 11(4):577-91. PMID: 25892230; PMCID: PMC4438771.
      Citations:    
    34. Osman AA, Neskey DM, Katsonis P, Patel AA, Ward AM, Hsu TK, Hicks SC, McDonald TO, Ow TJ, Alves MO, Pickering CR, Skinner HD, Zhao M, Sturgis EM, Kies MS, El-Naggar A, Perrone F, Licitra L, Bossi P, Kimmel M, Frederick MJ, Lichtarge O, Myers JN. Evolutionary Action Score of TP53 Coding Variants Is Predictive of Platinum Response in Head and Neck Cancer Patients. Cancer Res. 2015 Apr 01; 75(7):1205-15. PMID: 25691460; PMCID: PMC4615655.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    35. Neskey DM, Osman AA, Ow TJ, Katsonis P, McDonald T, Hicks SC, Hsu TK, Pickering CR, Ward A, Patel A, Yordy JS, Skinner HD, Giri U, Sano D, Story MD, Beadle BM, El-Naggar AK, Kies MS, William WN, Caulin C, Frederick M, Kimmel M, Myers JN, Lichtarge O. Evolutionary Action Score of TP53 Identifies High-Risk Mutations Associated with Decreased Survival and Increased Distant Metastases in Head and Neck Cancer. Cancer Res. 2015 Apr 01; 75(7):1527-36. PMID: 25634208; PMCID: PMC4383697.
      Citations: 80     Fields:    Translation:HumansCells
    36. Osman AA, Monroe MM, Ortega Alves MV, Patel AA, Katsonis P, Fitzgerald AL, Neskey DM, Frederick MJ, Woo SH, Caulin C, Hsu TK, McDonald TO, Kimmel M, Meyn RE, Lichtarge O, Myers JN. Wee-1 kinase inhibition overcomes cisplatin resistance associated with high-risk TP53 mutations in head and neck cancer through mitotic arrest followed by senescence. Mol Cancer Ther. 2015 Feb; 14(2):608-19. PMID: 25504633; PMCID: PMC4557970.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    37. Pickering CR, Zhou JH, Lee JJ, Drummond JA, Peng SA, Saade RE, Tsai KY, Curry JL, Tetzlaff MT, Lai SY, Yu J, Muzny DM, Doddapaneni H, Shinbrot E, Covington KR, Zhang J, Seth S, Caulin C, Clayman GL, El-Naggar AK, Gibbs RA, Weber RS, Myers JN, Wheeler DA, Frederick MJ. Mutational landscape of aggressive cutaneous squamous cell carcinoma. Clin Cancer Res. 2014 Dec 15; 20(24):6582-92. PMID: 25303977; PMCID: PMC4367811.
      Citations: 210     Fields:    Translation:Humans
    38. Pickering CR, Zhang J, Neskey DM, Zhao M, Jasser SA, Wang J, Ward A, Tsai CJ, Ortega Alves MV, Zhou JH, Drummond J, El-Naggar AK, Gibbs R, Weinstein JN, Wheeler DA, Wang J, Frederick MJ, Myers JN. Squamous cell carcinoma of the oral tongue in young non-smokers is genomically similar to tumors in older smokers. Clin Cancer Res. 2014 Jul 15; 20(14):3842-8. PMID: 24874835; PMCID: PMC4102633.
      Citations: 56     Fields:    Translation:Humans
    39. Michailidi C, Marchionni L, Pickering CR, Frederick MJ, Myers JN, Yegnasubramanian S, Hadar T, Noordhuis MG, Zizkova V, Fertig E, Agrawal N, Westra W, Koch W, Califano J, Velculescu VE, Sidransky D, Guerrero-Preston R. Key tumor suppressor genes inactivated by "greater promoter" methylation and somatic mutations in head and neck cancer. Epigenetics. 2014 Jul; 9(7):1031-46. PMID: 24786473; PMCID: PMC4143405.
      Citations: 68     Fields:    Translation:HumansCells
    40. Hah JH, Zhao M, Pickering CR, Frederick MJ, Andrews GA, Jasser SA, Fooshee DR, Milas ZL, Galer C, Sano D, William WN, Kim E, Heymach J, Byers LA, Papadimitrakopoulou V, Myers JN. HRAS mutations and resistance to the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib in head and neck squamous cell carcinoma cells. Head Neck. 2014 Nov; 36(11):1547-54. PMID: 24123531; PMCID: PMC4010580.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    41. Gadhikar MA, Sciuto MR, Alves MV, Pickering CR, Osman AA, Neskey DM, Zhao M, Fitzgerald AL, Myers JN, Frederick MJ. Chk1/2 inhibition overcomes the cisplatin resistance of head and neck cancer cells secondary to the loss of functional p53. Mol Cancer Ther. 2013 Sep; 12(9):1860-73. PMID: 23839309; PMCID: PMC3955083.
      Citations: 59     Fields:    Translation:HumansCells
    42. Henderson YC, Toro-Serra R, Chen Y, Ryu J, Frederick MJ, Zhou G, Gallick GE, Lai SY, Clayman GL. Src inhibitors in suppression of papillary thyroid carcinoma growth. Head Neck. 2014 Mar; 36(3):375-84. PMID: 23729178; PMCID: PMC4401074.
      Citations: 11     Fields:    Translation:AnimalsCells
    43. Pickering CR, Zhang J, Yoo SY, Bengtsson L, Moorthy S, Neskey DM, Zhao M, Ortega Alves MV, Chang K, Drummond J, Cortez E, Xie TX, Zhang D, Chung W, Issa JP, Zweidler-McKay PA, Wu X, El-Naggar AK, Weinstein JN, Wang J, Muzny DM, Gibbs RA, Wheeler DA, Myers JN, Frederick MJ. Integrative genomic characterization of oral squamous cell carcinoma identifies frequent somatic drivers. Cancer Discov. 2013 Jul; 3(7):770-81. PMID: 23619168; PMCID: PMC3858325.
      Citations: 241     Fields:    Translation:HumansCells
    44. Takahashi Y, Kupferman ME, Bell D, Jiffar T, Lee JG, Xie TX, Li NW, Zhao M, Frederick MJ, Gelbard A, Myers JN, Hanna EY. Establishment and characterization of novel cell lines from sinonasal undifferentiated carcinoma. Clin Cancer Res. 2012 Nov 15; 18(22):6178-87. PMID: 23032744; PMCID: PMC3513379.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    45. Loyo M, Li RJ, Bettegowda C, Pickering CR, Frederick MJ, Myers JN, Agrawal N. Lessons learned from next-generation sequencing in head and neck cancer. Head Neck. 2013 Mar; 35(3):454-63. PMID: 22907887; PMCID: PMC3715072.
      Citations: 27     Fields:    Translation:Humans
    46. Agrawal N, Frederick MJ, Pickering CR, Bettegowda C, Chang K, Li RJ, Fakhry C, Xie TX, Zhang J, Wang J, Zhang N, El-Naggar AK, Jasser SA, Weinstein JN, Drummond JA, Muzny DM, Wu Y, Wood LD, Hruban RH, Westra WH, Koch WM, Califano JA, Gibbs RA, Sidransky D, Vogelstein B, Velculescu VE, Papadopoulos N, Wheeler DA, Kinzler KW, Myers JN, Trevi?o L. Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science. 2011 Aug 26; 333(6046):1154-7. PMID: 21798897; PMCID: PMC3162986.
      Citations: 840     Fields:    Translation:HumansAnimalsCells
    47. Sano D, Fooshee DR, Zhao M, Andrews GA, Frederick MJ, Galer C, Milas ZL, Morrow PK, Myers JN. Targeted molecular therapy of head and neck squamous cell carcinoma with the tyrosine kinase inhibitor vandetanib in a mouse model. Head Neck. 2011 Mar; 33(3):349-58. PMID: 20629091; PMCID: PMC2958241.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    48. Frederick MJ, VanMeter AJ, Gadhikar MA, Henderson YC, Yao H, Pickering CC, Williams MD, El-Naggar AK, Sandulache V, Tarco E, Myers JN, Clayman GL, Liotta LA, Petricoin EF, Calvert VS, Fodale V, Wang J, Weber RS. Phosphoproteomic analysis of signaling pathways in head and neck squamous cell carcinoma patient samples. Am J Pathol. 2011 Feb; 178(2):548-71. PMID: 21281788; PMCID: PMC3070553.
      Citations: 16     Fields:    Translation:HumansCells
    49. Sandulache VC, Ow TJ, Pickering CR, Frederick MJ, Zhou G, Fokt I, Davis-Malesevich M, Priebe W, Myers JN. Glucose, not glutamine, is the dominant energy source required for proliferation and survival of head and neck squamous carcinoma cells. Cancer. 2011 Jul 01; 117(13):2926-38. PMID: 21692052; PMCID: PMC3135768.
      Citations: 64     Fields:    Translation:HumansCells
    50. Gule MK, Chen Y, Sano D, Frederick MJ, Zhou G, Zhao M, Milas ZL, Galer CE, Henderson YC, Jasser SA, Schwartz DL, Bankson JA, Myers JN, Lai SY. Targeted therapy of VEGFR2 and EGFR significantly inhibits growth of anaplastic thyroid cancer in an orthotopic murine model. Clin Cancer Res. 2011 Apr 15; 17(8):2281-91. PMID: 21220477; PMCID: PMC3079006.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    51. Henderson YC, Chen Y, Frederick MJ, Lai SY, Clayman GL. MEK inhibitor PD0325901 significantly reduces the growth of papillary thyroid carcinoma cells in vitro and in vivo. Mol Cancer Ther. 2010 Jul; 9(7):1968-76. PMID: 20587665; PMCID: PMC2935263.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    52. Henderson YC, Frederick MJ, Wang MT, Hollier LM, Clayman GL. LBP-1b, LBP-9, and LBP-32/MGR detected in syncytiotrophoblasts from first-trimester human placental tissue and their transcriptional regulation. DNA Cell Biol. 2008 Feb; 27(2):71-9. PMID: 18004979.
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    53. Shellenberger TD, Mazumdar A, Henderson Y, Briggs K, Wang M, Chattopadhyay C, Jayakumar A, Frederick M, Clayman GL. Headpin: a serpin with endogenous and exogenous suppression of angiogenesis. Cancer Res. 2005 Dec 15; 65(24):11501-9. PMID: 16357159.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    54. Jayakumar A, Kang Y, Henderson Y, Mitsudo K, Liu X, Briggs K, Wang M, Frederick MJ, El-Naggar AK, Clayman GL, Beb?k Z. Consequences of C-terminal domains and N-terminal signal peptide deletions on LEKTI secretion, stability, and subcellular distribution. Arch Biochem Biophys. 2005 Mar 01; 435(1):89-102. PMID: 15680911.
      Citations: 8     Fields:    Translation:HumansCells
    55. Shellenberger TD, Wang M, Gujrati M, Jayakumar A, Strieter RM, Burdick MD, Ioannides CG, Efferson CL, El-Naggar AK, Roberts D, Clayman GL, Frederick MJ. BRAK/CXCL14 is a potent inhibitor of angiogenesis and a chemotactic factor for immature dendritic cells. Cancer Res. 2004 Nov 15; 64(22):8262-70. PMID: 15548693.
      Citations: 85     Fields:    Translation:HumansCells
    56. Jayakumar A, Kang Y, Mitsudo K, Henderson Y, Frederick MJ, Wang M, El-Naggar AK, Marx UC, Briggs K, Clayman GL. Expression of LEKTI domains 6-9' in the baculovirus expression system: recombinant LEKTI domains 6-9' inhibit trypsin and subtilisin A. Protein Expr Purif. 2004 May; 35(1):93-101. PMID: 15039071.
      Citations: 11     Fields:    Translation:AnimalsCells
    57. Jayakumar A, Cataltepe S, Kang Y, Frederick MJ, Mitsudo K, Henderson Y, Crawford SE, Silverman GA, Clayman GL. Production of serpins using baculovirus expression systems. Methods. 2004 Feb; 32(2):177-84. PMID: 14698630.
      Citations: 3     Fields:    Translation:AnimalsCells
    58. Gonzalez HE, Gujrati M, Frederick M, Henderson Y, Arumugam J, Spring PW, Mitsudo K, Kim HW, Clayman GL. Identification of 9 genes differentially expressed in head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg. 2003 Jul; 129(7):754-9. PMID: 12874078.
      Citations:    
    59. Mitsudo K, Jayakumar A, Henderson Y, Frederick MJ, Kang Y, Wang M, El-Naggar AK, Clayman GL. Inhibition of serine proteinases plasmin, trypsin, subtilisin A, cathepsin G, and elastase by LEKTI: a kinetic analysis. Biochemistry. 2003 Apr 08; 42(13):3874-81. PMID: 12667078.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    60. Jayakumar A, Kang Y, Frederick MJ, Pak SC, Henderson Y, Holton PR, Mitsudo K, Silverman GA, EL-Naggar AK, Clayman GL, Br?mme D. Inhibition of the cysteine proteinases cathepsins K and L by the serpin headpin (SERPINB13): a kinetic analysis. Arch Biochem Biophys. 2003 Jan 15; 409(2):367-74. PMID: 12504904.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
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