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Balancing GRK2 and EPAC1 levels prevents and relieves chronic pain.
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Balancing GRK2 and EPAC1 levels prevents and relieves chronic pain.
Balancing GRK2 and EPAC1 levels prevents and relieves chronic pain. J Clin Invest. 2013 Dec; 123(12):5023-34.
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PubMed
subject areas
Animals
Carrageenan
Cattle
Chronic Pain
Cyclic AMP
Dinoprostone
Female
Ganglia, Spinal
Gene Expression Regulation
Gene Silencing
Genetic Therapy
G-Protein-Coupled Receptor Kinase 2
Guanine Nucleotide Exchange Factors
Hindlimb
Hyperalgesia
Injections, Spinal
Mice
Mice, Inbred C57BL
Models, Animal
Nociceptors
Oligonucleotides, Antisense
Oligopeptides
Recombinant Fusion Proteins
Sciatic Nerve
Second Messenger Systems
Sensory Receptor Cells