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MELANIE SAMUEL

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Neuroscience
DivisionNeuroscience
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    Other Positions
    TitleAssistant Professor
    InstitutionBaylor College of Medicine
    DepartmentHuffington Center on Aging
    DivisionHuffington Ctr on Aging

    TitleAssistant Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Ophthalmology
    DivisionOphthalmology


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    K99AG044444     (SAMUEL, MELANIE A)Sep 1, 2013 - May 31, 2015
    NIH/NIA
    Molecular Mechanisms of Age-related Synaptic Disorganization
    Role: Principal Investigator

    R00AG044444     (SAMUEL, MELANIE A)Apr 1, 2015 - Jan 31, 2018
    NIH/NIA
    Molecular Mechanisms of Age-related Synaptic Disorganization
    Role: Principal Investigator

    DP2EY027984     (SAMUEL, MELANIE A)Sep 30, 2016 - Sep 29, 2021
    NIH/NEI
    Synaptic Reprogramming of Adult Neurons
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Albrecht NE, Alevy J, Jiang D, Burger CA, Liu BI, Li F, Wang J, Kim SY, Hsu CW, Kalaga S, Udensi U, Asomugha C, Bohat R, Gaspero A, Justice MJ, Westenskow PD, Yamamoto S, Seavitt JR, Beaudet AL, Dickinson ME, Samuel MA. Rapid and Integrative Discovery of Retina Regulatory Molecules. Cell Rep. 2018 Aug 28; 24(9):2506-2519. PMID: 30157441.
      View in: PubMed
    2. Sarin S, Zuniga-Sanchez E, Kurmangaliyev YZ, Cousins H, Patel M, Hernandez J, Zhang KX, Samuel MA, Morey M, Sanes JR, Zipursky SL. Role for Wnt Signaling in Retinal Neuropil Development: Analysis via RNA-Seq and In Vivo Somatic CRISPR Mutagenesis. Neuron. 2018 Apr 04; 98(1):109-126.e8. PMID: 29576390.
      View in: PubMed
    3. Samuel MA, Voinescu PE, Lilley BN, de Cabo R, Foretz M, Viollet B, Pawlyk B, Sandberg MA, Vavvas DG, Sanes JR. LKB1 and AMPK regulate synaptic remodeling in old age. Nat Neurosci. 2014 Sep; 17(9):1190-7. PMID: 25086610.
      View in: PubMed
    4. Hussmann KL, Samuel MA, Kim KS, Diamond MS, Fredericksen BL. Differential replication of pathogenic and nonpathogenic strains of West Nile virus within astrocytes. J Virol. 2013 Mar; 87(5):2814-22. PMID: 23269784.
      View in: PubMed
    5. Samuel MA, Valdez G, Tapia JC, Lichtman JW, Sanes JR. Agrin and synaptic laminin are required to maintain adult neuromuscular junctions. PLoS One. 2012; 7(10):e46663. PMID: 23056392.
      View in: PubMed
    6. Samuel MA, Zhang Y, Meister M, Sanes JR. Age-related alterations in neurons of the mouse retina. J Neurosci. 2011 Nov 02; 31(44):16033-44. PMID: 22049445.
      View in: PubMed
    7. Parameswaran P, Sklan E, Wilkins C, Burgon T, Samuel MA, Lu R, Ansel KM, Heissmeyer V, Einav S, Jackson W, Doukas T, Paranjape S, Polacek C, dos Santos FB, Jalili R, Babrzadeh F, Gharizadeh B, Grimm D, Kay M, Koike S, Sarnow P, Ronaghi M, Ding SW, Harris E, Chow M, Diamond MS, Kirkegaard K, Glenn JS, Fire AZ. Six RNA viruses and forty-one hosts: viral small RNAs and modulation of small RNA repertoires in vertebrate and invertebrate systems. PLoS Pathog. 2010 Feb 12; 6(2):e1000764. PMID: 20169186.
      View in: PubMed
    8. Szretter KJ, Samuel MA, Gilfillan S, Fuchs A, Colonna M, Diamond MS. The immune adaptor molecule SARM modulates tumor necrosis factor alpha production and microglia activation in the brainstem and restricts West Nile Virus pathogenesis. J Virol. 2009 Sep; 83(18):9329-38. PMID: 19587044.
      View in: PubMed
    9. Diamond MS, Mehlhop E, Oliphant T, Samuel MA. The host immunologic response to West Nile encephalitis virus. Front Biosci (Landmark Ed). 2009 Jan 01; 14:3024-34. PMID: 19273254.
      View in: PubMed
    10. Daffis S, Samuel MA, Suthar MS, Gale M, Diamond MS. Toll-like receptor 3 has a protective role against West Nile virus infection. J Virol. 2008 Nov; 82(21):10349-58. PMID: 18715906.
      View in: PubMed
    11. Daffis S, Samuel MA, Suthar MS, Keller BC, Gale M, Diamond MS. Interferon regulatory factor IRF-7 induces the antiviral alpha interferon response and protects against lethal West Nile virus infection. J Virol. 2008 Sep; 82(17):8465-75. PMID: 18562536.
      View in: PubMed
    12. Samuel MA, Wang H, Siddharthan V, Morrey JD, Diamond MS. Axonal transport mediates West Nile virus entry into the central nervous system and induces acute flaccid paralysis. Proc Natl Acad Sci U S A. 2007 Oct 23; 104(43):17140-5. PMID: 17939996.
      View in: PubMed
    13. Noueiry AO, Olivo PD, Slomczynska U, Zhou Y, Buscher B, Geiss B, Engle M, Roth RM, Chung KM, Samuel M, Diamond MS. Identification of novel small-molecule inhibitors of West Nile virus infection. J Virol. 2007 Nov; 81(21):11992-2004. PMID: 17715228.
      View in: PubMed
    14. Daffis S, Samuel MA, Keller BC, Gale M, Diamond MS. Cell-specific IRF-3 responses protect against West Nile virus infection by interferon-dependent and -independent mechanisms. PLoS Pathog. 2007 Jul 27; 3(7):e106. PMID: 17676997.
      View in: PubMed
    15. Samuel MA, Morrey JD, Diamond MS. Caspase 3-dependent cell death of neurons contributes to the pathogenesis of West Nile virus encephalitis. J Virol. 2007 Mar; 81(6):2614-23. PMID: 17192305.
      View in: PubMed
    16. Samuel MA, Diamond MS. Pathogenesis of West Nile Virus infection: a balance between virulence, innate and adaptive immunity, and viral evasion. J Virol. 2006 Oct; 80(19):9349-60. PMID: 16973541.
      View in: PubMed
    17. Keller BC, Fredericksen BL, Samuel MA, Mock RE, Mason PW, Diamond MS, Gale M. Resistance to alpha/beta interferon is a determinant of West Nile virus replication fitness and virulence. J Virol. 2006 Oct; 80(19):9424-34. PMID: 16973548.
      View in: PubMed
    18. Samuel MA, Whitby K, Keller BC, Marri A, Barchet W, Williams BR, Silverman RH, Gale M, Diamond MS. PKR and RNase L contribute to protection against lethal West Nile Virus infection by controlling early viral spread in the periphery and replication in neurons. J Virol. 2006 Jul; 80(14):7009-19. PMID: 16809306.
      View in: PubMed
    19. Shrestha B, Wang T, Samuel MA, Whitby K, Craft J, Fikrig E, Diamond MS. Gamma interferon plays a crucial early antiviral role in protection against West Nile virus infection. J Virol. 2006 Jun; 80(11):5338-48. PMID: 16699014.
      View in: PubMed
    20. Rosenke K, Samuel MA, McDowell ET, Toerne MA, Fortunato EA. An intact sequence-specific DNA-binding domain is required for human cytomegalovirus-mediated sequestration of p53 and may promote in vivo binding to the viral genome during infection. Virology. 2006 Apr 25; 348(1):19-34. PMID: 16455125.
      View in: PubMed
    21. Shiryaev SA, Ratnikov BI, Chekanov AV, Sikora S, Rozanov DV, Godzik A, Wang J, Smith JW, Huang Z, Lindberg I, Samuel MA, Diamond MS, Strongin AY. Cleavage targets and the D-arginine-based inhibitors of the West Nile virus NS3 processing proteinase. Biochem J. 2006 Jan 15; 393(Pt 2):503-11. PMID: 16229682.
      View in: PubMed
    22. Shrestha B, Samuel MA, Diamond MS. CD8+ T cells require perforin to clear West Nile virus from infected neurons. J Virol. 2006 Jan; 80(1):119-29. PMID: 16352536.
      View in: PubMed
    23. Pepin KM, Samuel MA, Wichman HA. Variable pleiotropic effects from mutations at the same locus hamper prediction of fitness from a fitness component. Genetics. 2006 Apr; 172(4):2047-56. PMID: 16361237.
      View in: PubMed
    24. Samuel MA, Diamond MS. Alpha/beta interferon protects against lethal West Nile virus infection by restricting cellular tropism and enhancing neuronal survival. J Virol. 2005 Nov; 79(21):13350-61. PMID: 16227257.
      View in: PubMed
    25. Klein RS, Lin E, Zhang B, Luster AD, Tollett J, Samuel MA, Engle M, Diamond MS. Neuronal CXCL10 directs CD8+ T-cell recruitment and control of West Nile virus encephalitis. J Virol. 2005 Sep; 79(17):11457-66. PMID: 16103196.
      View in: PubMed
    26. Pierson TC, Diamond MS, Ahmed AA, Valentine LE, Davis CW, Samuel MA, Hanna SL, Puffer BA, Doms RW. An infectious West Nile virus that expresses a GFP reporter gene. Virology. 2005 Mar 30; 334(1):28-40. PMID: 15749120.
      View in: PubMed
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