MELANIE SAMUEL

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Neuroscience
AddressOne Baylor Plaza
Houston, TX 77030
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    Other Positions
    TitleAssistant Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Ophthalmology
    DivisionOphthalmology

    TitleAssistant Professor
    InstitutionBaylor College of Medicine
    DepartmentHuffington Center on Aging
    DivisionHuffington Ctr on Aging


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    K99AG044444     (SAMUEL, MELANIE A)Sep 1, 2013 - May 31, 2015
    NIH/NIA
    Molecular Mechanisms of Age-related Synaptic Disorganization
    Role: Principal Investigator

    R00AG044444     (SAMUEL, MELANIE A)Apr 1, 2015 - Jan 31, 2018
    NIH/NIA
    Molecular Mechanisms of Age-related Synaptic Disorganization
    Role: Principal Investigator

    DP2EY027984     (SAMUEL, MELANIE A)Sep 30, 2016 - Sep 29, 2021
    NIH/NEI
    Synaptic Reprogramming of Adult Neurons
    Role: Principal Investigator

    R56AG061808     (SAMUEL, MELANIE A)Aug 15, 2019 - Jul 31, 2020
    NIH/NIA
    Synaptic decline in retina as a predictor of Alzheimer's disease
    Role: Principal Investigator

    R01EY030458     (SAMUEL, MELANIE A)Sep 1, 2019 - Jun 30, 2024
    NIH/NEI
    Molecular Basis of Outer Retina Development and Repair
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Burger CA, Albrecht NE, Jiang D, Liang JH, Poché RA, Samuel MA. LKB1 and AMPK instruct cone nuclear position to modify visual function. Cell Rep. 2021 Feb 02; 34(5):108698. PMID: 33535040.
      Citations:    Fields:    
    2. Burger CA, Jiang D, Li F, Samuel MA. C1q Regulates Horizontal Cell Neurite Confinement in the Outer Retina. Front Neural Circuits. 2020; 14:583391. PMID: 33177995.
      Citations: 1     Fields:    
    3. Burger CA, Alevy J, Casasent AK, Jiang D, Albrecht NE, Liang JH, Hirano AA, Brecha NC, Samuel MA. LKB1 coordinates neurite remodeling to drive synapse layer emergence in the outer retina. Elife. 2020 05 07; 9. PMID: 32378514.
      Citations:    Fields:    
    4. Li F, Jiang D, Samuel MA. Microglia in the developing retina. Neural Dev. 2019 12 30; 14(1):12. PMID: 31888774.
      Citations: 5     Fields:    Translation:AnimalsCells
    5. Jiang D, Burger CA, Casasent AK, Albrecht NE, Li F, Samuel MA. Spatiotemporal gene expression patterns reveal molecular relatedness between retinal laminae. J Comp Neurol. 2020 04 01; 528(5):729-755. PMID: 31609468.
      Citations: 1     Fields:    
    6. Greer PL, Samuel MA. Becoming a Principal Investigator: Designing and Navigating Your Academic Adventure. Neuron. 2019 09 25; 103(6):959-963. PMID: 31557459.
      Citations:    Fields:    Translation:Humans
    7. Alevy J, Burger CA, Albrecht NE, Jiang D, Samuel MA. Progressive myoclonic epilepsy-associated gene Kctd7 regulates retinal neurovascular patterning and function. Neurochem Int. 2019 10; 129:104486. PMID: 31175897.
      Citations:    Fields:    Translation:HumansAnimalsCells
    8. Albrecht NE, Alevy J, Jiang D, Burger CA, Liu BI, Li F, Wang J, Kim SY, Hsu CW, Kalaga S, Udensi U, Asomugha C, Bohat R, Gaspero A, Justice MJ, Westenskow PD, Yamamoto S, Seavitt JR, Beaudet AL, Dickinson ME, Samuel MA. Rapid and Integrative Discovery of Retina Regulatory Molecules. Cell Rep. 2018 08 28; 24(9):2506-2519. PMID: 30157441.
      Citations: 4     Fields:    Translation:HumansCells
    9. Sarin S, Zuniga-Sanchez E, Kurmangaliyev YZ, Cousins H, Patel M, Hernandez J, Zhang KX, Samuel MA, Morey M, Sanes JR, Zipursky SL. Role for Wnt Signaling in Retinal Neuropil Development: Analysis via RNA-Seq and In Vivo Somatic CRISPR Mutagenesis. Neuron. 2018 04 04; 98(1):109-126.e8. PMID: 29576390.
      Citations: 11     Fields:    Translation:AnimalsCells
    10. Samuel MA, Voinescu PE, Lilley BN, de Cabo R, Foretz M, Viollet B, Pawlyk B, Sandberg MA, Vavvas DG, Sanes JR. LKB1 and AMPK regulate synaptic remodeling in old age. Nat Neurosci. 2014 Sep; 17(9):1190-7. PMID: 25086610.
      Citations: 29     Fields:    Translation:AnimalsCells
    11. Hussmann KL, Samuel MA, Kim KS, Diamond MS, Fredericksen BL. Differential replication of pathogenic and nonpathogenic strains of West Nile virus within astrocytes. J Virol. 2013 Mar; 87(5):2814-22. PMID: 23269784.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    12. Samuel MA, Valdez G, Tapia JC, Lichtman JW, Sanes JR. Agrin and synaptic laminin are required to maintain adult neuromuscular junctions. PLoS One. 2012; 7(10):e46663. PMID: 23056392.
      Citations: 46     Fields:    Translation:AnimalsCells
    13. Samuel MA, Zhang Y, Meister M, Sanes JR. Age-related alterations in neurons of the mouse retina. J Neurosci. 2011 Nov 02; 31(44):16033-44. PMID: 22049445.
      Citations: 50     Fields:    Translation:AnimalsCells
    14. Parameswaran P, Sklan E, Wilkins C, Burgon T, Samuel MA, Lu R, Ansel KM, Heissmeyer V, Einav S, Jackson W, Doukas T, Paranjape S, Polacek C, dos Santos FB, Jalili R, Babrzadeh F, Gharizadeh B, Grimm D, Kay M, Koike S, Sarnow P, Ronaghi M, Ding SW, Harris E, Chow M, Diamond MS, Kirkegaard K, Glenn JS, Fire AZ. Six RNA viruses and forty-one hosts: viral small RNAs and modulation of small RNA repertoires in vertebrate and invertebrate systems. PLoS Pathog. 2010 Feb 12; 6(2):e1000764. PMID: 20169186.
      Citations: 118     Fields:    Translation:AnimalsCells
    15. Szretter KJ, Samuel MA, Gilfillan S, Fuchs A, Colonna M, Diamond MS. The immune adaptor molecule SARM modulates tumor necrosis factor alpha production and microglia activation in the brainstem and restricts West Nile Virus pathogenesis. J Virol. 2009 Sep; 83(18):9329-38. PMID: 19587044.
      Citations: 60     Fields:    Translation:AnimalsCells
    16. Diamond MS, Mehlhop E, Oliphant T, Samuel MA. The host immunologic response to West Nile encephalitis virus. Front Biosci (Landmark Ed). 2009 Jan 01; 14:3024-34. PMID: 19273254.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    17. Daffis S, Samuel MA, Suthar MS, Gale M, Diamond MS. Toll-like receptor 3 has a protective role against West Nile virus infection. J Virol. 2008 Nov; 82(21):10349-58. PMID: 18715906.
      Citations: 152     Fields:    Translation:AnimalsCells
    18. Daffis S, Samuel MA, Suthar MS, Keller BC, Gale M, Diamond MS. Interferon regulatory factor IRF-7 induces the antiviral alpha interferon response and protects against lethal West Nile virus infection. J Virol. 2008 Sep; 82(17):8465-75. PMID: 18562536.
      Citations: 88     Fields:    Translation:AnimalsCells
    19. Samuel MA, Wang H, Siddharthan V, Morrey JD, Diamond MS. Axonal transport mediates West Nile virus entry into the central nervous system and induces acute flaccid paralysis. Proc Natl Acad Sci U S A. 2007 Oct 23; 104(43):17140-5. PMID: 17939996.
      Citations: 82     Fields:    Translation:AnimalsCells
    20. Noueiry AO, Olivo PD, Slomczynska U, Zhou Y, Buscher B, Geiss B, Engle M, Roth RM, Chung KM, Samuel M, Diamond MS. Identification of novel small-molecule inhibitors of West Nile virus infection. J Virol. 2007 Nov; 81(21):11992-2004. PMID: 17715228.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    21. Daffis S, Samuel MA, Keller BC, Gale M, Diamond MS. Cell-specific IRF-3 responses protect against West Nile virus infection by interferon-dependent and -independent mechanisms. PLoS Pathog. 2007 Jul 27; 3(7):e106. PMID: 17676997.
      Citations: 109     Fields:    Translation:AnimalsCells
    22. Samuel MA, Morrey JD, Diamond MS. Caspase 3-dependent cell death of neurons contributes to the pathogenesis of West Nile virus encephalitis. J Virol. 2007 Mar; 81(6):2614-23. PMID: 17192305.
      Citations: 79     Fields:    Translation:AnimalsCells
    23. Samuel MA, Diamond MS. Pathogenesis of West Nile Virus infection: a balance between virulence, innate and adaptive immunity, and viral evasion. J Virol. 2006 Oct; 80(19):9349-60. PMID: 16973541.
      Citations: 146     Fields:    Translation:HumansAnimalsCells
    24. Keller BC, Fredericksen BL, Samuel MA, Mock RE, Mason PW, Diamond MS, Gale M. Resistance to alpha/beta interferon is a determinant of West Nile virus replication fitness and virulence. J Virol. 2006 Oct; 80(19):9424-34. PMID: 16973548.
      Citations: 112     Fields:    Translation:HumansAnimalsCells
    25. Samuel MA, Whitby K, Keller BC, Marri A, Barchet W, Williams BR, Silverman RH, Gale M, Diamond MS. PKR and RNase L contribute to protection against lethal West Nile Virus infection by controlling early viral spread in the periphery and replication in neurons. J Virol. 2006 Jul; 80(14):7009-19. PMID: 16809306.
      Citations: 136     Fields:    Translation:AnimalsCells
    26. Shrestha B, Wang T, Samuel MA, Whitby K, Craft J, Fikrig E, Diamond MS. Gamma interferon plays a crucial early antiviral role in protection against West Nile virus infection. J Virol. 2006 Jun; 80(11):5338-48. PMID: 16699014.
      Citations: 91     Fields:    Translation:AnimalsCells
    27. Rosenke K, Samuel MA, McDowell ET, Toerne MA, Fortunato EA. An intact sequence-specific DNA-binding domain is required for human cytomegalovirus-mediated sequestration of p53 and may promote in vivo binding to the viral genome during infection. Virology. 2006 Apr 25; 348(1):19-34. PMID: 16455125.
      Citations: 18     Fields:    Translation:HumansCells
    28. Shiryaev SA, Ratnikov BI, Chekanov AV, Sikora S, Rozanov DV, Godzik A, Wang J, Smith JW, Huang Z, Lindberg I, Samuel MA, Diamond MS, Strongin AY. Cleavage targets and the D-arginine-based inhibitors of the West Nile virus NS3 processing proteinase. Biochem J. 2006 Jan 15; 393(Pt 2):503-11. PMID: 16229682.
      Citations: 36     Fields:    Translation:AnimalsCells
    29. Shrestha B, Samuel MA, Diamond MS. CD8+ T cells require perforin to clear West Nile virus from infected neurons. J Virol. 2006 Jan; 80(1):119-29. PMID: 16352536.
      Citations: 108     Fields:    Translation:AnimalsCells
    30. Pepin KM, Samuel MA, Wichman HA. Variable pleiotropic effects from mutations at the same locus hamper prediction of fitness from a fitness component. Genetics. 2006 Apr; 172(4):2047-56. PMID: 16361237.
      Citations: 16     Fields:    Translation:Cells
    31. Samuel MA, Diamond MS. Alpha/beta interferon protects against lethal West Nile virus infection by restricting cellular tropism and enhancing neuronal survival. J Virol. 2005 Nov; 79(21):13350-61. PMID: 16227257.
      Citations: 203     Fields:    Translation:AnimalsCells
    32. Klein RS, Lin E, Zhang B, Luster AD, Tollett J, Samuel MA, Engle M, Diamond MS. Neuronal CXCL10 directs CD8+ T-cell recruitment and control of West Nile virus encephalitis. J Virol. 2005 Sep; 79(17):11457-66. PMID: 16103196.
      Citations: 196     Fields:    Translation:AnimalsCells
    33. Pierson TC, Diamond MS, Ahmed AA, Valentine LE, Davis CW, Samuel MA, Hanna SL, Puffer BA, Doms RW. An infectious West Nile virus that expresses a GFP reporter gene. Virology. 2005 Mar 30; 334(1):28-40. PMID: 15749120.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
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