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EDWARD C COOPER

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Neurology
DivisionNeurology
AddressDepartment of Neurology, NB302
One Baylor Plaza
Houston TX 77030
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Neuroscience
    DivisionNeuroscience


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Mulkey SB, Ben-Zeev B, Nicolai J, Carroll JL, Grønborg S, Jiang YH, Joshi N, Kelly M, Koolen DA, Mikati MA, Park K, Pearl PL, Scheffer IE, Spillmann RC, Taglialatela M, Vieker S, Weckhuysen S, Cooper EC, Cilio MR. Neonatal nonepileptic myoclonus is a prominent clinical feature of KCNQ2 gain-of-function variants R201C and R201H. Epilepsia. 2017 Mar; 58(3):436-445. PMID: 28139826.
      View in: PubMed
    2. Lopez AY, Wang X, Xu M, Maheshwari A, Curry D, Lam S, Adesina AM, Noebels JL, Sun QQ, Cooper EC. Ankyrin-G isoform imbalance and interneuronopathy link epilepsy and bipolar disorder. Mol Psychiatry. 2016 Dec 13. PMID: 27956739.
      View in: PubMed
    3. Millichap JJ, Miceli F, De Maria M, Keator C, Joshi N, Tran B, Soldovieri MV, Ambrosino P, Shashi V, Mikati MA, Cooper EC, Taglialatela M. Infantile spasms and encephalopathy without preceding neonatal seizures caused by KCNQ2 R198Q, a gain-of-function variant. Epilepsia. 2017 Jan; 58(1):e10-e15. PMID: 27861786.
      View in: PubMed
    4. Millichap JJ, Park KL, Tsuchida T, Ben-Zeev B, Carmant L, Flamini R, Joshi N, Levisohn PM, Marsh E, Nangia S, Narayanan V, Ortiz-Gonzalez XR, Patterson MC, Pearl PL, Porter B, Ramsey K, McGinnis EL, Taglialatela M, Tracy M, Tran B, Venkatesan C, Weckhuysen S, Cooper EC. KCNQ2 encephalopathy: Features, mutational hot spots, and ezogabine treatment of 11 patients. Neurol Genet. 2016 Oct; 2(5):e96. PMID: 27602407; PMCID: PMC4995058.
    5. Xu M, Cooper EC. An Ankyrin-G N-terminal Gate and Protein Kinase CK2 Dually Regulate Binding of Voltage-gated Sodium and KCNQ2/3 Potassium Channels. J Biol Chem. 2015 Jul 3; 290(27):16619-32. PMID: 25998125.
      View in: PubMed
    6. Hirst CS, Foong JP, Stamp LA, Fegan E, Dent S, Cooper EC, Lomax AE, Anderson CR, Bornstein JC, Young HM, McKeown SJ. Ion channel expression in the developing enteric nervous system. PLoS One. 2015; 10(3):e0123436. PMID: 25798587; PMCID: PMC4370736.
    7. Martinello K, Huang Z, Lujan R, Tran B, Watanabe M, Cooper EC, Brown DA, Shah MM. Cholinergic afferent stimulation induces axonal function plasticity in adult hippocampal granule cells. Neuron. 2015 Jan 21; 85(2):346-63. PMID: 25578363; PMCID: PMC4306544.
    8. Chang KJ, Zollinger DR, Susuki K, Sherman DL, Makara MA, Brophy PJ, Cooper EC, Bennett V, Mohler PJ, Rasband MN. Glial ankyrins facilitate paranodal axoglial junction assembly. Nat Neurosci. 2014 Dec; 17(12):1673-81. PMID: 25362471; PMCID: PMC4260775.
    9. Ho TS, Zollinger DR, Chang KJ, Xu M, Cooper EC, Stankewich MC, Bennett V, Rasband MN. A hierarchy of ankyrin-spectrin complexes clusters sodium channels at nodes of Ranvier. Nat Neurosci. 2014 Dec; 17(12):1664-72. PMID: 25362473; PMCID: PMC4271271.
    10. Kang S, Xu M, Cooper EC, Hoshi N. Channel-anchored protein kinase CK2 and protein phosphatase 1 reciprocally regulate KCNQ2-containing M-channels via phosphorylation of calmodulin. J Biol Chem. 2014 Apr 18; 289(16):11536-44. PMID: 24627475; PMCID: PMC4036288.
    11. Battefeld A, Tran BT, Gavrilis J, Cooper EC, Kole MH. Heteromeric Kv7.2/7.3 channels differentially regulate action potential initiation and conduction in neocortical myelinated axons. J Neurosci. 2014 Mar 5; 34(10):3719-32. PMID: 24599470; PMCID: PMC3942587.
    12. Kole MH, Cooper EC. Axonal Kv7.2/7.3 channels: caught in the act. Channels (Austin). 2014; 8(4):288-9. PMID: 25171180.
      View in: PubMed
    13. Millichap JJ, Cooper EC. KCNQ2 Potassium Channel Epileptic Encephalopathy Syndrome: Divorce of an Electro-Mechanical Couple? Epilepsy Curr. 2012 Jul; 12(4):150-2. PMID: 22936888; PMCID: PMC3423209.
    14. Cooper EC. Made for "anchorin": Kv7.2/7.3 (KCNQ2/KCNQ3) channels and the modulation of neuronal excitability in vertebrate axons. Semin Cell Dev Biol. 2011 Apr; 22(2):185-92. PMID: 20940059; PMCID: PMC3070838.
    15. Cooper EC. The cadherin superfamily and epileptogenesis: end of the beginning? Epilepsy Curr. 2009 May-Jun; 9(3):87-9. PMID: 19471581; PMCID: PMC2685888.
    16. Raol YH, Lapides DA, Keating JG, Brooks-Kayal AR, Cooper EC. A KCNQ channel opener for experimental neonatal seizures and status epilepticus. Ann Neurol. 2009 Mar; 65(3):326-36. PMID: 19334075; PMCID: PMC2666110.
    17. Hill AS, Nishino A, Nakajo K, Zhang G, Fineman JR, Selzer ME, Okamura Y, Cooper EC. Ion channel clustering at the axon initial segment and node of Ranvier evolved sequentially in early chordates. PLoS Genet. 2008 Dec; 4(12):e1000317. PMID: 19112491; PMCID: PMC2597720.
    18. Jin Z, Liang GH, Cooper EC, Jarlebark L. Expression and localization of K channels KCNQ2 and KCNQ3 in the mammalian cochlea. Audiol Neurootol. 2009; 14(2):98-105. PMID: 18827480; PMCID: PMC3030994.
    19. Cooper EC. Funny team member makes key plays, but leaves the dendritic field when hit hard. Epilepsy Curr. 2008 Jul-Aug; 8(4):103-5. PMID: 18596878; PMCID: PMC2442154.
    20. Shah MM, Migliore M, Valencia I, Cooper EC, Brown DA. Functional significance of axonal Kv7 channels in hippocampal pyramidal neurons. Proc Natl Acad Sci U S A. 2008 Jun 3; 105(22):7869-74. PMID: 18515424; PMCID: PMC2408483.
    21. Cooper EC, Pan Z. Putting an end to DEND: a severe neonatal-onset epilepsy is treatable if recognized early. Neurology. 2007 Sep 25; 69(13):1310-1. PMID: 17893291.
      View in: PubMed
    22. Cooper EC. (What to do) when epilepsy gene mutations stop making sense. Epilepsy Curr. 2007 Jan-Feb; 7(1):23-5. PMID: 17304347; PMCID: PMC1797886.
    23. Cooper EC. Exploiting the other inhibitory ion: KCNQ potassium channels and regulation of excitability in developing and mature brain. Epilepsy Curr. 2006 Jul-Aug; 6(4):133-5. PMID: 17260036; PMCID: PMC1783435.
    24. Schwarz JR, Glassmeier G, Cooper EC, Kao TC, Nodera H, Tabuena D, Kaji R, Bostock H. KCNQ channels mediate IKs, a slow K+ current regulating excitability in the rat node of Ranvier. J Physiol. 2006 May 15; 573(Pt 1):17-34. PMID: 16527853; PMCID: PMC1779690.
    25. Pan Z, Kao T, Horvath Z, Lemos J, Sul JY, Cranstoun SD, Bennett V, Scherer SS, Cooper EC. A common ankyrin-G-based mechanism retains KCNQ and NaV channels at electrically active domains of the axon. J Neurosci. 2006 Mar 8; 26(10):2599-613. PMID: 16525039.
      View in: PubMed
    26. Surti TS, Huang L, Jan YN, Jan LY, Cooper EC. Identification by mass spectrometry and functional characterization of two phosphorylation sites of KCNQ2/KCNQ3 channels. Proc Natl Acad Sci U S A. 2005 Dec 6; 102(49):17828-33. PMID: 16319223; PMCID: PMC1297712.
    27. Cooper EC, Baraban SC. Pain without gain (of function): sodium channel dysfunction in epilepsy. Epilepsy Curr. 2004 Jul-Aug; 4(4):158-9. PMID: 16059485; PMCID: PMC1176357.
    28. Devaux JJ, Kleopa KA, Cooper EC, Scherer SS. KCNQ2 is a nodal K+ channel. J Neurosci. 2004 Feb 4; 24(5):1236-44. PMID: 14762142.
      View in: PubMed
    29. Tsao JW, Cooper EC. Reflex-sensitive spinal segmental myoclonus associated with vitamin B12 deficiency. Neurology. 2003 Sep 23; 61(6):867-8. PMID: 14504348.
      View in: PubMed
    30. Cooper EC, Jan LY. M-channels: neurological diseases, neuromodulation, and drug development. Arch Neurol. 2003 Apr; 60(4):496-500. PMID: 12707061.
      View in: PubMed
    31. Cooper EC, Harrington E, Jan YN, Jan LY. M channel KCNQ2 subunits are localized to key sites for control of neuronal network oscillations and synchronization in mouse brain. J Neurosci. 2001 Dec 15; 21(24):9529-40. PMID: 11739564.
      View in: PubMed
    32. Castro PA, Cooper EC, Lowenstein DH, Baraban SC. Hippocampal heterotopia lack functional Kv4.2 potassium channels in the methylazoxymethanol model of cortical malformations and epilepsy. J Neurosci. 2001 Sep 1; 21(17):6626-34. PMID: 11517252.
      View in: PubMed
    33. Cooper EC. Potassium channels: how genetic studies of epileptic syndromes open paths to new therapeutic targets and drugs. Epilepsia. 2001; 42 Suppl 5:49-54. PMID: 11887968.
      View in: PubMed
    34. Cooper EC, Aldape KD, Abosch A, Barbaro NM, Berger MS, Peacock WS, Jan YN, Jan LY. Colocalization and coassembly of two human brain M-type potassium channel subunits that are mutated in epilepsy. Proc Natl Acad Sci U S A. 2000 Apr 25; 97(9):4914-9. PMID: 10781098; PMCID: PMC18332.
    35. Cooper EC, Jan LY. Ion channel genes and human neurological disease: recent progress, prospects, and challenges. Proc Natl Acad Sci U S A. 1999 Apr 27; 96(9):4759-66. PMID: 10220366; PMCID: PMC34105.
    36. Gleeson JG, Minnerath SR, Fox JW, Allen KM, Luo RF, Hong SE, Berg MJ, Kuzniecky R, Reitnauer PJ, Borgatti R, Mira AP, Guerrini R, Holmes GL, Rooney CM, Berkovic S, Scheffer I, Cooper EC, Ricci S, Cusmai R, Crawford TO, Leroy R, Andermann E, Wheless JW, Dobyns WB, Walsh CA, et al. Characterization of mutations in the gene doublecortin in patients with double cortex syndrome. Ann Neurol. 1999 Feb; 45(2):146-53. PMID: 9989615.
      View in: PubMed
    37. Brenman JE, Topinka JR, Cooper EC, McGee AW, Rosen J, Milroy T, Ralston HJ, Bredt DS. Localization of postsynaptic density-93 to dendritic microtubules and interaction with microtubule-associated protein 1A. J Neurosci. 1998 Nov 1; 18(21):8805-13. PMID: 9786987.
      View in: PubMed
    38. Cooper EC, Milroy A, Jan YN, Jan LY, Lowenstein DH. Presynaptic localization of Kv1.4-containing A-type potassium channels near excitatory synapses in the hippocampus. J Neurosci. 1998 Feb 1; 18(3):965-74. PMID: 9437018.
      View in: PubMed
    39. Gleeson JG, Allen KM, Fox JW, Lamperti ED, Berkovic S, Scheffer I, Cooper EC, Dobyns WB, Minnerath SR, Ross ME, Walsh CA. Doublecortin, a brain-specific gene mutated in human X-linked lissencephaly and double cortex syndrome, encodes a putative signaling protein. Cell. 1998 Jan 9; 92(1):63-72. PMID: 9489700.
      View in: PubMed
    40. Agnew WS, Cooper EC, Shenkel S, Correa AM, James WM, Ukomadu C, Tomiko SA. Voltage-sensitive sodium channels: agents that perturb inactivation gating. Ann N Y Acad Sci. 1991; 625:200-23. PMID: 1647724.
      View in: PubMed
    41. Shenkel S, Cooper EC, James W, Agnew WS, Sigworth FJ. Purified, modified eel sodium channels are active in planar bilayers in the absence of activating neurotoxins. Proc Natl Acad Sci U S A. 1989 Dec; 86(23):9592-6. PMID: 2556720; PMCID: PMC298544.
    42. Cooper EC, Agnew WS. Reconstituted voltage-sensitive sodium channels from eel electroplax: activation of permeability by quaternary lidocaine, N-bromoacetamide, and N-bromosuccinimide. J Membr Biol. 1989 Nov; 111(3):253-64. PMID: 2557451.
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    43. Cooper EC, Tomiko SA, Agnew WS. Reconstituted voltage-sensitive sodium channel from Electrophorus electricus: chemical modifications that alter regulation of ion permeability. Proc Natl Acad Sci U S A. 1987 Sep; 84(17):6282-6. PMID: 2442755; PMCID: PMC299055.
    44. Agnew WS, Tomiko SA, Rosenberg RL, Emerick MC, Cooper EC. The structure and function of the voltage-sensitive Na channel. Ann N Y Acad Sci. 1986; 479:238-56. PMID: 2433994.
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    45. Greenberg DA, Carpenter CL, Cooper EC. Stimulation of calcium uptake in PC12 cells by the dihydropyridine agonist BAY K 8644. J Neurochem. 1985 Sep; 45(3):990-3. PMID: 2411863.
      View in: PubMed
    46. Greenberg DA, Cooper EC, Carpenter CL. Reversible dihydropyridine isothiocyanate binding to brain calcium channels. J Neurochem. 1985 Jan; 44(1):319-21. PMID: 2578060.
      View in: PubMed
    47. Greenberg DA, Cooper EC, Carpenter CL. Phenytoin interacts with calcium channels in brain membranes. Ann Neurol. 1984 Nov; 16(5):616-7. PMID: 6095733.
      View in: PubMed
    48. Greenberg DA, Cooper EC. Effect of ethanol on [3H]nitrendipine binding to calcium channels in brain membranes. Alcohol Clin Exp Res. 1984 Nov-Dec; 8(6):568-71. PMID: 6097136.
      View in: PubMed
    49. Greenberg DA, Cooper EC, Carpenter CL. Calcium entry activators: distinct sites of dihydropyridine and aminopyridine action. Neurosci Lett. 1984 Sep 7; 50(1-3):279-82. PMID: 6208517.
      View in: PubMed
    50. Greenberg DA, Cooper EC, Carpenter CL. Calcium channel 'agonist' BAY K 8644 inhibits calcium antagonist binding to brain and PC12 cell membranes. Brain Res. 1984 Jul 9; 305(2):365-8. PMID: 6204725.
      View in: PubMed
    51. Greenberg DA, Cooper EC, Gordon A, Diamond I. Ethanol and the gamma-aminobutyric acid-benzodiazepine receptor complex. J Neurochem. 1984 Apr; 42(4):1062-8. PMID: 6321657.
      View in: PubMed
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