Last Name


TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Neurology
AddressDepartment of Neurology, NB302
One Baylor Plaza
Houston TX 77030
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Neuroscience

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Lopez AY, Wang X, Xu M, Maheshwari A, Curry D, Lam S, Adesina AM, Noebels JL, Sun QQ, Cooper EC. Ankyrin-G isoform imbalance and interneuronopathy link epilepsy and bipolar disorder. Mol Psychiatry. 2016 Dec 13. PMID: 27956739.
      View in: PubMed
    2. Millichap JJ, Miceli F, De Maria M, Keator C, Joshi N, Tran B, Soldovieri MV, Ambrosino P, Shashi V, Mikati MA, Cooper EC, Taglialatela M. Infantile spasms and encephalopathy without preceding neonatal seizures caused by KCNQ2 R198Q, a gain-of-function variant. Epilepsia. 2017 Jan; 58(1):e10-e15. PMID: 27861786.
      View in: PubMed
    3. Millichap JJ, Park KL, Tsuchida T, Ben-Zeev B, Carmant L, Flamini R, Joshi N, Levisohn PM, Marsh E, Nangia S, Narayanan V, Ortiz-Gonzalez XR, Patterson MC, Pearl PL, Porter B, Ramsey K, McGinnis EL, Taglialatela M, Tracy M, Tran B, Venkatesan C, Weckhuysen S, Cooper EC. KCNQ2 encephalopathy: Features, mutational hot spots, and ezogabine treatment of 11 patients. Neurol Genet. 2016 Oct; 2(5):e96. PMID: 27602407; PMCID: PMC4995058.
    4. Xu M, Cooper EC. An Ankyrin-G N-terminal Gate and Protein Kinase CK2 Dually Regulate Binding of Voltage-gated Sodium and KCNQ2/3 Potassium Channels. J Biol Chem. 2015 Jul 3; 290(27):16619-32. PMID: 25998125.
      View in: PubMed
    5. Hirst CS, Foong JP, Stamp LA, Fegan E, Dent S, Cooper EC, Lomax AE, Anderson CR, Bornstein JC, Young HM, McKeown SJ. Ion channel expression in the developing enteric nervous system. PLoS One. 2015; 10(3):e0123436. PMID: 25798587; PMCID: PMC4370736.
    6. Martinello K, Huang Z, Lujan R, Tran B, Watanabe M, Cooper EC, Brown DA, Shah MM. Cholinergic afferent stimulation induces axonal function plasticity in adult hippocampal granule cells. Neuron. 2015 Jan 21; 85(2):346-63. PMID: 25578363; PMCID: PMC4306544.
    7. Chang KJ, Zollinger DR, Susuki K, Sherman DL, Makara MA, Brophy PJ, Cooper EC, Bennett V, Mohler PJ, Rasband MN. Glial ankyrins facilitate paranodal axoglial junction assembly. Nat Neurosci. 2014 Dec; 17(12):1673-81. PMID: 25362471; PMCID: PMC4260775.
    8. Ho TS, Zollinger DR, Chang KJ, Xu M, Cooper EC, Stankewich MC, Bennett V, Rasband MN. A hierarchy of ankyrin-spectrin complexes clusters sodium channels at nodes of Ranvier. Nat Neurosci. 2014 Dec; 17(12):1664-72. PMID: 25362473; PMCID: PMC4271271.
    9. Kang S, Xu M, Cooper EC, Hoshi N. Channel-anchored protein kinase CK2 and protein phosphatase 1 reciprocally regulate KCNQ2-containing M-channels via phosphorylation of calmodulin. J Biol Chem. 2014 Apr 18; 289(16):11536-44. PMID: 24627475; PMCID: PMC4036288.
    10. Battefeld A, Tran BT, Gavrilis J, Cooper EC, Kole MH. Heteromeric Kv7.2/7.3 channels differentially regulate action potential initiation and conduction in neocortical myelinated axons. J Neurosci. 2014 Mar 5; 34(10):3719-32. PMID: 24599470; PMCID: PMC3942587.
    11. Kole MH, Cooper EC. Axonal Kv7.2/7.3 channels: caught in the act. Channels (Austin). 2014; 8(4):288-9. PMID: 25171180.
      View in: PubMed
    12. Millichap JJ, Cooper EC. KCNQ2 Potassium Channel Epileptic Encephalopathy Syndrome: Divorce of an Electro-Mechanical Couple? Epilepsy Curr. 2012 Jul; 12(4):150-2. PMID: 22936888; PMCID: PMC3423209.
    13. Cooper EC. Made for "anchorin": Kv7.2/7.3 (KCNQ2/KCNQ3) channels and the modulation of neuronal excitability in vertebrate axons. Semin Cell Dev Biol. 2011 Apr; 22(2):185-92. PMID: 20940059; PMCID: PMC3070838.
    14. Hill AS, Nishino A, Nakajo K, Zhang G, Fineman JR, Selzer ME, Okamura Y, Cooper EC. Ion channel clustering at the axon initial segment and node of Ranvier evolved sequentially in early chordates. PLoS Genet. 2008 Dec; 4(12):e1000317. PMID: 19112491; PMCID: PMC2597720.
    15. Jin Z, Liang GH, Cooper EC, Jarlebark L. Expression and localization of K channels KCNQ2 and KCNQ3 in the mammalian cochlea. Audiol Neurootol. 2009; 14(2):98-105. PMID: 18827480; PMCID: PMC3030994.
    16. Shah MM, Migliore M, Valencia I, Cooper EC, Brown DA. Functional significance of axonal Kv7 channels in hippocampal pyramidal neurons. Proc Natl Acad Sci U S A. 2008 Jun 3; 105(22):7869-74. PMID: 18515424; PMCID: PMC2408483.
    17. Cooper EC. Exploiting the other inhibitory ion: KCNQ potassium channels and regulation of excitability in developing and mature brain. Epilepsy Curr. 2006 Jul-Aug; 6(4):133-5. PMID: 17260036; PMCID: PMC1783435.
    18. Schwarz JR, Glassmeier G, Cooper EC, Kao TC, Nodera H, Tabuena D, Kaji R, Bostock H. KCNQ channels mediate IKs, a slow K+ current regulating excitability in the rat node of Ranvier. J Physiol. 2006 May 15; 573(Pt 1):17-34. PMID: 16527853; PMCID: PMC1779690.
    19. Pan Z, Kao T, Horvath Z, Lemos J, Sul JY, Cranstoun SD, Bennett V, Scherer SS, Cooper EC. A common ankyrin-G-based mechanism retains KCNQ and NaV channels at electrically active domains of the axon. J Neurosci. 2006 Mar 8; 26(10):2599-613. PMID: 16525039.
      View in: PubMed
    20. Surti TS, Huang L, Jan YN, Jan LY, Cooper EC. Identification by mass spectrometry and functional characterization of two phosphorylation sites of KCNQ2/KCNQ3 channels. Proc Natl Acad Sci U S A. 2005 Dec 6; 102(49):17828-33. PMID: 16319223; PMCID: PMC1297712.
    21. Devaux JJ, Kleopa KA, Cooper EC, Scherer SS. KCNQ2 is a nodal K+ channel. J Neurosci. 2004 Feb 4; 24(5):1236-44. PMID: 14762142.
      View in: PubMed
    22. Cooper EC, Jan LY. M-channels: neurological diseases, neuromodulation, and drug development. Arch Neurol. 2003 Apr; 60(4):496-500. PMID: 12707061.
      View in: PubMed
    23. Cooper EC, Harrington E, Jan YN, Jan LY. M channel KCNQ2 subunits are localized to key sites for control of neuronal network oscillations and synchronization in mouse brain. J Neurosci. 2001 Dec 15; 21(24):9529-40. PMID: 11739564.
      View in: PubMed
    24. Castro PA, Cooper EC, Lowenstein DH, Baraban SC. Hippocampal heterotopia lack functional Kv4.2 potassium channels in the methylazoxymethanol model of cortical malformations and epilepsy. J Neurosci. 2001 Sep 1; 21(17):6626-34. PMID: 11517252.
      View in: PubMed
    25. Cooper EC, Aldape KD, Abosch A, Barbaro NM, Berger MS, Peacock WS, Jan YN, Jan LY. Colocalization and coassembly of two human brain M-type potassium channel subunits that are mutated in epilepsy. Proc Natl Acad Sci U S A. 2000 Apr 25; 97(9):4914-9. PMID: 10781098; PMCID: PMC18332.
    26. Brenman JE, Topinka JR, Cooper EC, McGee AW, Rosen J, Milroy T, Ralston HJ, Bredt DS. Localization of postsynaptic density-93 to dendritic microtubules and interaction with microtubule-associated protein 1A. J Neurosci. 1998 Nov 1; 18(21):8805-13. PMID: 9786987.
      View in: PubMed
    27. Cooper EC, Milroy A, Jan YN, Jan LY, Lowenstein DH. Presynaptic localization of Kv1.4-containing A-type potassium channels near excitatory synapses in the hippocampus. J Neurosci. 1998 Feb 1; 18(3):965-74. PMID: 9437018.
      View in: PubMed
    28. Cooper EC, Agnew WS. Reconstituted voltage-sensitive sodium channels from eel electroplax: activation of permeability by quaternary lidocaine, N-bromoacetamide, and N-bromosuccinimide. J Membr Biol. 1989 Nov; 111(3):253-64. PMID: 2557451.
      View in: PubMed
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