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MEGUMI MATHISON

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Surgery
Address1709 DRYDEN RD., STE. 1500
HOUSTON TX 77030
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    Heart failure is a leading cause of death in developed countries. Recent advances in interventional cardiology and cardiac surgery have made it possible to save numerous patient lives after myocardial infarction. However, those patients eventually develop end-stage heart failure since the loss of cardiac muscle is never replaced with new muscle. Our study focus is on regenerating cardiac muscle by transdifferentiating cardiac fibroblasts into cardiomyocytes. We reported that Gata4, Mef2c, and Tbx5 overexpression transdifferentiated cardiac fibroblasts into cardiomyocyte-like cells in vitro, and improved cardiac function in vivo. Our goal is to translate this in-situ cardiomyocyte regeneration into clinical therapy.

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    Cardiovascular disease, Cardiac regeneration


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Patel V, Mathison M, Singh VP, Yang J, Rosengart TK. Direct Cardiac Cellular Reprogramming for Cardiac Regeneration. Curr Treat Options Cardiovasc Med. 2016 Sep; 18(9):58. PMID: 27554127.
      View in: PubMed
    2. Mathison M, Singh VP, Gersch RP, Ramirez MO, Cooney A, Kaminsky SM, Chiuchiolo MJ, Nasser A, Yang J, Crystal RG, Rosengart TK. "Triplet" polycistronic vectors encoding Gata4, Mef2c, and Tbx5 enhances postinfarct ventricular functional improvement compared with singlet vectors. J Thorac Cardiovasc Surg. 2014 Oct; 148(4):1656-1664.e2. PMID: 24755332.
      View in: PubMed
    3. Mathison M, Gersch RP, Nasser A, Lilo S, Korman M, Fourman M, Hackett N, Shroyer K, Yang J, Ma Y, Crystal RG, Rosengart TK. In vivo cardiac cellular reprogramming efficacy is enhanced by angiogenic preconditioning of the infarcted myocardium with vascular endothelial growth factor. J Am Heart Assoc. 2012 Dec; 1(6):e005652. PMID: 23316332; PMCID: PMC3540681.
    4. Robinson KA, Li J, Mathison M, Redkar A, Cui J, Chronos NA, Matheny RG, Badylak SF. Extracellular matrix scaffold for cardiac repair. Circulation. 2005 Aug 30; 112(9 Suppl):I135-43. PMID: 16159805.
      View in: PubMed
    5. Cui J, Li J, Mathison M, Tondato F, Mulkey SP, Micko C, Chronos NA, Robinson KA. A clinically relevant large-animal model for evaluation of tissue-engineered cardiac surgical patch materials. Cardiovasc Revasc Med. 2005 Jul-Sep; 6(3):113-20. PMID: 16275607.
      View in: PubMed
    6. Dewey TM, Magee MJ, Edgerton JR, Mathison M, Tennison D, Mack MJ. Off-pump bypass grafting is safe in patients with left main coronary disease. Ann Thorac Surg. 2001 Sep; 72(3):788-91; discussion 792. PMID: 11565659.
      View in: PubMed
    7. Mathison M, Edgerton JR, Horswell JL, Akin JJ, Mack MJ. Analysis of hemodynamic changes during beating heart surgical procedures. Ann Thorac Surg. 2000 Oct; 70(4):1355-60; discussion 1360-1. PMID: 11081898.
      View in: PubMed
    8. Mathison M, Buffolo E, Jatene AD, Jatene FB, Reichenspurner H, Matheny RG, Shennib H, Akin JJ, Mack MJ. Right heart circulatory support facilities coronary artery bypass without cardiopulmonary bypass. Ann Thorac Surg. 2000 Sep; 70(3):1083-5. PMID: 11016382.
      View in: PubMed
    9. Ide H, Sato M, Fujiki T, Tonari K, Mathison M, Sudo K. [Two cases of surgical treatment of recrudescent Stanford type A dissection after early thrombogenic closure without intimal tear]. Jpn J Thorac Cardiovasc Surg. 1998 Jan; 46(1):85-90. PMID: 9513531.
      View in: PubMed
    10. Egami J, Fujiki T, Sudo K, Koisizawa T, Mathison M, Kokubo J, Sasagawa N, Honda K, Ide H, Ikeda K. Aneurysm of a branch of the subclavian artery with multiple arteriovenous fistulae. J Cardiovasc Surg (Torino). 1996 Aug; 37(4):355-7. PMID: 8698779.
      View in: PubMed
    11. Mathison M, Whitfield C, Haydock DA, Kerr AR. Risk factors in heart transplantation. A statistical study of New Zealand cases. Jpn Heart J. 1996 Mar; 37(2):243-9. PMID: 8676551.
      View in: PubMed
    12. Sekiguchi A, Matsunaga H, Kotsuka Y, Yagyu K, Mathison M, Morizuki O, Ono M, Furuse A. [A role of valvuloplasty in surgical treatment of isolated tricuspid regurgitation]. Kyobu Geka. 1993 Aug; 46(9):751-5. PMID: 8361098.
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    13. Takeshita M, Mathison M, Yagyu K, Kotsuka Y, Matsunaga H, Furuse A. [Congenital bicuspid aortic valve: stenotic type and insufficient type]. J Cardiol Suppl. 1992; 28:133-7; discussion 138. PMID: 1418872.
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    14. Mathison M, Furuse A, Kotsuda H, Tanaka O, Chikada M. [Quadricuspid aortic valve: case reports]. Kyobu Geka. 1990 May; 43(5):383-8. PMID: 2374316.
      View in: PubMed
    15. Kawauchi M, Yazaki Y, Oka T, Okabe H, Mathison M, Nakajima J, Morizuki O, Kawaguchi G, Koseni K, Takeda M, et al. Diagnosis of cardiac allograft rejection by the detection of circulating plasma cardiac myosin light chains. Jpn J Surg. 1990 Mar; 20(2):212-6. PMID: 2342239.
      View in: PubMed
    16. Nakajima J, Shindo G, Makuuchi H, Mathison M, Tanaka K, Deguchi J, Furuse A, Kobori O. [Successful resection of mediastinal and abdominal recurrent tumors of esophageal leiomyosarcoma 12 years after surgery]. Kyobu Geka. 1990 Feb; 43(2):102-5. PMID: 2137887.
      View in: PubMed
    17. Mathison M. Atherosclerosis and blood flow velocity. J Thorac Cardiovasc Surg. 1989 Aug; 98(2):301-2. PMID: 2755166.
      View in: PubMed
    18. Mathison M, Furuse A, Asano K. Doppler analysis of flow velocity profile at the aortic root. J Am Coll Cardiol. 1988 Oct; 12(4):947-54. PMID: 2971085.
      View in: PubMed
    19. Atsumi N, Itoh K, Ohokawa Y, Nagata N, Mathison M, Kawataki M, Yasui S, Miyazawa Y, Takarada M. [Clinical study on cardiac pacing in infants and children]. Kyobu Geka. 1987 Aug; 40(9):697-702. PMID: 3682472.
      View in: PubMed
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