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WEHRENS, XANDER
One or more keywords matched the following items that are connected to WEHRENS, XANDER
Item TypeName
Academic Article Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2.
Academic Article Mouse electrocardiography: an interval of thirty years.
Academic Article Use of an intact mouse skeletal muscle preparation for endocrine vascular studies: evaluation of the model.
Academic Article Angiogenesis-independent cardioprotection in FGF-1 transgenic mice.
Academic Article Analysis of calstabin2 (FKBP12.6)-ryanodine receptor interactions: rescue of heart failure by calstabin2 in mice.
Academic Article Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy.
Academic Article Ambulatory ECG recording in mice.
Academic Article Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias.
Academic Article Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure.
Academic Article CaMKII effects on inotropic but not lusitropic force frequency responses require phospholamban.
Academic Article Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression.
Academic Article Inhibition of CaMKII phosphorylation of RyR2 prevents inducible ventricular arrhythmias in mice with Duchenne muscular dystrophy.
Academic Article NFATc2 is a necessary mediator of calcineurin-dependent cardiac hypertrophy and heart failure.
Academic Article Intracellular calcium leak due to FKBP12.6 deficiency in mice facilitates the inducibility of atrial fibrillation.
Academic Article 20p12.3 microdeletion predisposes to Wolff-Parkinson-White syndrome with variable neurocognitive deficits.
Academic Article Exercise training during diabetes attenuates cardiac ryanodine receptor dysregulation.
Academic Article Calmodulin kinase II is required for fight or flight sinoatrial node physiology.
Academic Article Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice.
Academic Article PKC inhibition ameliorates the cardiac phenotype in a mouse model of myotonic dystrophy type 1.
Academic Article Sudden infant death syndrome in mice with an inherited mutation in RyR2.
Academic Article Heart-specific overexpression of CUGBP1 reproduces functional and molecular abnormalities of myotonic dystrophy type 1.
Academic Article Pitx2 prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specification.
Academic Article Transthoracic echocardiography in mice.
Academic Article Genetic inhibition of PKA phosphorylation of RyR2 prevents dystrophic cardiomyopathy.
Academic Article Transverse aortic constriction in mice.
Academic Article Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling.
Academic Article Defects in ankyrin-based membrane protein targeting pathways underlie atrial fibrillation.
Academic Article Inhibition of CaMKII phosphorylation of RyR2 prevents induction of atrial fibrillation in FKBP12.6 knockout mice.
Academic Article Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure.
Academic Article CaMKII inhibition rescues proarrhythmic phenotypes in the model of human ankyrin-B syndrome.
Academic Article Effects of CaMKII-mediated phosphorylation of ryanodine receptor type 2 on islet calcium handling, insulin secretion, and glucose tolerance.
Academic Article Overexpression of cAMP-response element modulator causes abnormal growth and development of the atrial myocardium resulting in a substrate for sustained atrial fibrillation in mice.
Academic Article Circadian rhythms govern cardiac repolarization and arrhythmogenesis.
Academic Article Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+-Ca2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation.
Academic Article Role of RyR2 phosphorylation at S2814 during heart failure progression.
Academic Article Human stanniocalcin-1 suppresses angiotensin II-induced superoxide generation in cardiomyocytes through UCP3-mediated anti-oxidant pathway.
Academic Article Atrial identity is determined by a COUP-TFII regulatory network.
Academic Article FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death.
Academic Article Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias.
Academic Article Alternative splicing: a key mechanism for ankyrin-B functional diversity?
Academic Article Animal models of arrhythmogenic cardiomyopathy.
Academic Article Accelerated development of pressure overload-induced cardiac hypertrophy and dysfunction in an RyR2-R176Q knockin mouse model.
Academic Article Programmed electrical stimulation in mice.
Academic Article Disrupted junctional membrane complexes and hyperactive ryanodine receptors after acute junctophilin knockdown in mice.
Academic Article Calcium-calmodulin dependent protein kinase II (CaMKII): a main signal responsible for early reperfusion arrhythmias.
Academic Article Pathogenesis of lethal cardiac arrhythmias in Mecp2 mutant mice: implication for therapy in Rett syndrome.
Academic Article Targeted deletion of microRNA-22 promotes stress-induced cardiac dilation and contractile dysfunction.
Academic Article Epac2 mediates cardiac ?1-adrenergic-dependent sarcoplasmic reticulum Ca2+ leak and arrhythmia.
Concept Mice, Inbred mdx
Concept Mice, Knockout
Concept Mice, Inbred NOD
Concept Mice, Obese
Concept Mice
Concept Mice, Mutant Strains
Concept Mice, Inbred C57BL
Concept Mice, Transgenic
Academic Article Junctophilin-2 is necessary for T-tubule maturation during mouse heart development.
Academic Article Critical roles of junctophilin-2 in T-tubule and excitation-contraction coupling maturation during postnatal development.
Academic Article Oxidized Ca(2+)/calmodulin-dependent protein kinase II triggers atrial fibrillation.
Academic Article microRNA-22 promotes heart failure through coordinate suppression of PPAR/ERR-nuclear hormone receptor transcription.
Academic Article Mutation E169K in junctophilin-2 causes atrial fibrillation due to impaired RyR2 stabilization.
Academic Article Ryanodine receptor phosphorylation by oxidized CaMKII contributes to the cardiotoxic effects of cardiac glycosides.
Academic Article Ryanodine receptor-mediated calcium leak drives progressive development of an atrial fibrillation substrate in a transgenic mouse model.
Academic Article Microtubule-mediated defects in junctophilin-2 trafficking contribute to myocyte transverse-tubule remodeling and Ca2+ handling dysfunction in heart failure.
Academic Article Alternative splicing regulates vesicular trafficking genes in cardiomyocytes during postnatal heart development.
Academic Article Impaired local regulation of ryanodine receptor type 2 by protein phosphatase 1 promotes atrial fibrillation.
Academic Article Pitx2-microRNA pathway that delimits sinoatrial node development and inhibits predisposition to atrial fibrillation.
Academic Article CaMKII-dependent phosphorylation of cardiac ryanodine receptors regulates cell death in cardiac ischemia/reperfusion injury.
Academic Article Long-term simulated microgravity causes cardiac RyR2 phosphorylation and arrhythmias in mice.
Academic Article Reduced junctional Na+/Ca2+-exchanger activity contributes to sarcoplasmic reticulum Ca2+ leak in junctophilin-2-deficient mice.
Academic Article TWIK-2 channel deficiency leads to pulmonary hypertension through a rho-kinase-mediated process.
Academic Article Lack of UCP3 does not affect skeletal muscle mitochondrial function under lipid-challenged conditions, but leads to sudden cardiac death.
Academic Article Genetic deletion of Rnd3/RhoE results in mouse heart calcium leakage through upregulation of protein kinase A signaling.
Academic Article Loss of microRNA-106b-25 cluster promotes atrial fibrillation by enhancing ryanodine receptor type-2 expression and calcium release.
Academic Article Oxidative stress and ca(2+) release events in mouse cardiomyocytes.
Academic Article Alterations in the interactome of serine/threonine protein phosphatase type-1 in atrial fibrillation patients.
Academic Article Increased atrial arrhythmia susceptibility induced by intense endurance exercise in mice requires TNFa.
Academic Article The mitochondrial uniporter controls fight or flight heart rate increases.
Academic Article Treatment of cardiac arrhythmias in a mouse model of Rett syndrome with Na+-channel-blocking antiepileptic drugs.
Academic Article PHD2/3-dependent hydroxylation tunes cardiac response to ?-adrenergic stress via phospholamban.
Academic Article CaMKIId mediates ?-adrenergic effects on RyR2 phosphorylation and SR Ca(2+) leak and the pathophysiological response to chronic ?-adrenergic stimulation.
Academic Article Hrd1 and ER-Associated Protein Degradation, ERAD, are Critical Elements of the Adaptive ER Stress Response in Cardiac Myocytes.
Academic Article Expression and function of Kv1.1 potassium channels in human atria from patients with atrial fibrillation.
Academic Article Protein phosphatase 2A regulatory subunit B56a limits phosphatase activity in the heart.
Academic Article Crosstalk between RyR2 oxidation and phosphorylation contributes to cardiac dysfunction in mice with Duchenne muscular dystrophy.
Academic Article In silico prediction of drug therapy in catecholaminergic polymorphic ventricular tachycardia.
Academic Article Phospholamban ablation rescues the enhanced propensity to arrhythmias of mice with CaMKII-constitutive phosphorylation of RyR2 at site S2814.
Academic Article Cardiac expression of the CREM repressor isoform CREM-Ib?C-X in mice leads to arrhythmogenic alterations in ventricular cardiomyocytes.
Academic Article A Single Protein Kinase A or Calmodulin Kinase II Site Does Not Control the Cardiac Pacemaker Ca2+ Clock.
Academic Article Dysregulation of RBFOX2 Is an Early Event in Cardiac Pathogenesis of Diabetes.
Academic Article Increased Reliance on Muscle-based Thermogenesis upon Acute Minimization of Brown Adipose Tissue Function.
Academic Article Leaky RyR2 channels unleash a brainstem spreading depolarization mechanism of sudden cardiac death.
Academic Article Reversible redox modifications of ryanodine receptor ameliorate ventricular arrhythmias in the ischemic-reperfused heart.
Academic Article CaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift.
Academic Article SPEG (Striated Muscle Preferentially Expressed Protein Kinase) Is Essential for Cardiac Function by Regulating Junctional Membrane Complex Activity.
Academic Article Treatment of catecholaminergic polymorphic ventricular tachycardia in mice using novel RyR2-modifying drugs.
Academic Article Loss of glutaredoxin 3 impedes mammary lobuloalveolar development during pregnancy and lactation.
Academic Article SRC-1 Regulates Blood Pressure and Aortic Stiffness in Female Mice.
Academic Article Junctophilin-2 in the nanoscale organisation and functional signalling of ryanodine receptor clusters in cardiomyocytes.
Academic Article Calcium-calmodulin-dependent protein kinase mediates the intracellular signalling pathways of cardiac apoptosis in mice with impaired glucose tolerance.
Academic Article Methyl-CpG binding-protein 2 function in cholinergic neurons mediates cardiac arrhythmogenesis.
Academic Article Junctophilin-2 gene therapy rescues heart failure by normalizing RyR2-mediated Ca2+ release.
Academic Article Tead1 is required for maintaining adult cardiomyocyte function, and its loss results in lethal dilated cardiomyopathy.
Academic Article Distinct Cellular Basis for Early Cardiac Arrhythmias, the Cardinal Manifestation of Arrhythmogenic Cardiomyopathy, and the Skin Phenotype of Cardiocutaneous Syndromes.
Academic Article Early effects of Epac depend on the fine-tuning of the sarcoplasmic reticulum Ca2+ handling in cardiomyocytes.
Academic Article EL20, a potent antiarrhythmic compound, selectively inhibits calmodulin-deficient ryanodine receptor type 2.
Academic Article Hemodynamic and Pathologic Characterization of the TASK-1-/- Mouse Does Not Demonstrate Pulmonary Hypertension.
Academic Article Oxidized CaMKII (Ca2+/Calmodulin-Dependent Protein Kinase II) Is Essential for Ventricular Arrhythmia in a Mouse Model of Duchenne Muscular Dystrophy.
Academic Article Rearrangement of the Protein Phosphatase 1 Interactome During Heart Failure Progression.
Academic Article Enhanced Cardiomyocyte NLRP3 Inflammasome Signaling Promotes Atrial Fibrillation.
Academic Article Mouse Models of Cardiac Arrhythmias.
Academic Article Ablation of phospholamban rescues reperfusion arrhythmias but exacerbates myocardium infarction in hearts with Ca2+/calmodulin kinase II constitutive phosphorylation of ryanodine receptors.
Academic Article In Vivo Ryr2 Editing Corrects Catecholaminergic Polymorphic Ventricular Tachycardia.
Academic Article Protein Phosphatase 2A Regulates Cardiac Na+ Channels.
Academic Article Ranolazine prevents pressure overload-induced cardiac hypertrophy and heart failure by restoring aberrant Na+ and Ca2+ handling.
Academic Article Atrial-Specific Gene Delivery Using an Adeno-Associated Viral Vector.
Academic Article CRISPR -Mediated Expression of the Fetal Scn5a Isoform in Adult Mice Causes Conduction Defects and Arrhythmias.
Grant Ryanodine receptor regulation in post-operative atrial fibrillation
Grant Determining the Role of Junctophilin-2 in Cardiac Disease
Grant Development of novel compounds for the treatment of atrial fibrillation
Grant Regulation of Sarcoplasmic Reticulum Calcium Release in Heart Failure
Academic Article YAP Partially Reprograms Chromatin Accessibility to Directly Induce Adult Cardiogenesis In?Vivo.
Academic Article Cardiac-specific ablation of glutaredoxin 3 leads to cardiac hypertrophy and heart failure.
Academic Article Loss of Protein Phosphatase 1 Regulatory Subunit PPP1R3A Promotes Atrial Fibrillation.
Academic Article Junctophilin-2 expression rescues atrial dysfunction through polyadic junctional membrane complex biogenesis.
Academic Article Exercise restores dysregulated gene expression in a mouse model of arrhythmogenic cardiomyopathy.
Academic Article Depletion of Endothelial Prolyl Hydroxylase Domain Protein 2 and 3 Promotes Cardiomyocyte Proliferation and Prevents Ventricular Failure Induced by Myocardial Infarction.
Academic Article Calmodulin kinase II regulates atrial myocyte late sodium current, calcium handling, and atrial arrhythmia.
Academic Article Prevention of connexin-43 remodeling protects against Duchenne muscular dystrophy cardiomyopathy.
Academic Article Cardiac dysregulation following intrahippocampal kainate-induced status epilepticus.
Academic Article Nuclear localization of a novel calpain-2 mediated junctophilin-2 C-terminal cleavage peptide promotes cardiomyocyte remodeling.
Academic Article Loss of SPEG Inhibitory Phosphorylation of Ryanodine Receptor Type-2 Promotes Atrial Fibrillation.
Academic Article Atrial Myocyte NLRP3/CaMKII Nexus Forms a Substrate for Postoperative Atrial Fibrillation.
Academic Article Determinants of Ca2+ release restitution: Insights from genetically altered animals and mathematical modeling.
Academic Article Paracrine signalling by cardiac calcitonin controls atrial fibrogenesis and arrhythmia.
Academic Article Oxidized CaMKII and O-GlcNAcylation cause increased atrial fibrillation in diabetic mice by distinct mechanisms.
Academic Article Reversible cardiac disease features in an inducible CUG repeat RNA-expressing mouse model of myotonic dystrophy.
Academic Article Crucial Role of Mammalian Glutaredoxin 3 in Cardiac Energy Metabolism in Diet-induced Obese Mice Revealed by Transcriptome Analysis.
Academic Article Atrial-Specific LKB1 Knockdown Represents a Novel Mouse Model of Atrial Cardiomyopathy With Spontaneous Atrial Fibrillation.
Academic Article Cellular regeneration as a potential strategy to treat cardiac conduction disorders.
Academic Article Genetic inhibition of nuclear factor of activated T-cell c2 prevents atrial fibrillation in CREM transgenic mice.
Academic Article Reduction in Junctophilin 2 Expression in Cardiac Nodal Tissue Results in Intracellular Calcium-Driven Increase in Nodal Cell Automaticity.
Academic Article Prolonged ?-adrenergic stimulation disperses ryanodine receptor clusters in cardiomyocytes and has implications for heart failure.
Academic Article A microtubule-connexin-43 regulatory link suppresses arrhythmias and cardiac fibrosis in Duchenne muscular dystrophy mice.
Academic Article Mouse models of spontaneous atrial fibrillation.
Academic Article In-depth characterization of a mouse model of postoperative atrial fibrillation.
Academic Article Downregulation of FKBP5 Promotes Atrial Arrhythmogenesis.
Academic Article An improved reporter identifies ruxolitinib as a potent and cardioprotective CaMKII inhibitor.
Academic Article PPP1R12C Promotes Atrial Hypocontractility in Atrial Fibrillation.
Academic Article Characterization of atrial and ventricular remodeling in an improved minimally invasive mouse model of transverse aortic constriction.
Academic Article Chronic kidney disease promotes atrial fibrillation via inflammasome pathway activation.
Academic Article Speg interactions that regulate the stability of excitation-contraction coupling protein complexes in triads and dyads.
Academic Article Nonsense Variant PRDM16-Q187X Causes Impaired Myocardial Development and TGF-? Signaling Resulting in Noncompaction Cardiomyopathy in Humans and Mice.
Academic Article Atrial Proteomic Profiling Reveals a Switch Towards Profibrotic Gene Expression Program in CREM-Ib?C-X Mice with Persistent Atrial Fibrillation.
Academic Article Phosphorylation of RyR2 simultaneously expands the dyad and rearranges the tetramers.
Academic Article In Vivo Cardiac Electrophysiology in Mice: Determination of Atrial and Ventricular Arrhythmic Substrates.
Academic Article Altered myocardial lipid regulation in junctophilin-2-associated familial cardiomyopathies.
Academic Article Atrial proteomic profiling reveals a switch towards profibrotic gene expression program in CREM-Ib?C-X mice with persistent atrial fibrillation.
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