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VIERLING, JOHN
One or more keywords matched the following properties of VIERLING, JOHN
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keywords • Acute liver failure • Alcoholic and non-alcoholic fatty liver diseases • Alpha-1-antitrypsin deficiency • Autoimmune hepatitis • Cholangocarcinoma • Cirrhosis • Clinical therapeutic trials • Drug-induced liver injury • Gastroesophageal varices • Genetic and metabolic diseases • Hemochromatosis • Hepatic encephalopathy pre and post liver transplantation care • Hepatocellular carcinoma • Primary biliary cirrhosis • Primary sclerosing cholangitis • Viral hepatitis • Wilson's disease
overview Dr. John M. Vierling’s primary research interests are the immunopathogenic mechanisms involved in hepatobiliary injury caused by viral infection, autoimmunity, alloimmunity, and non-alcoholic fatty liver disease. Dr. Vierling’s basic science laboratory investigations have used murine models to study the immunopathogenesis of non-suppurative destructive cholangitis, which destroys bile ducts in primary biliary cirrhosis, an autoimmune liver disease, as well as in two alloimmune diseases, hepatic allograft rejection and chronic graft-versus-host disease. By emphasizing a "laboratory bench to bedside" philosophy, Dr. Vierling has also been active in the design and execution of clinical therapeutic trials of antiviral agents for treatment of hepatitis B and C infections in patients before and after liver transplantation, trials of immunosuppressive drugs in liver transplantation and autoimmune liver diseases, trials of new therapies for hepatic encephalopathy and antifibrotic agents to prevent or reverse cirrhosis. Dr. Vierling is the author of numerous research publications, reviews and chapters on these topics. Dr. Vierling directs Advanced Liver Therapies, a clinical research unit devoted to hepatobiliary diseases. He and his research staff are conducting phase 1-3 studies of diagnostics and therapies in chronic hepatitis B, chronic hepatitis C, primary biliary cirrhosis, non-alcoholic fatty liver disease, anti-fibrotic therapy to prevent cirrhosis, hepatic encephalopathy, and measurement of hepatocellular function using 13C-labeled compounds. Dr. Vierling is board certified in internal medicine and gastroenterology and a Fellow of the American College of Physicians. He created a liver transplant program at the University of olorado Health Sciences Center.
One or more keywords matched the following items that are connected to VIERLING, JOHN
Item TypeName
Academic Article Cell surface receptors in the liver.
Academic Article Electron microscopy of rejected human liver allografts.
Academic Article Incorporation of radiocopper into ceruloplasmin in normal subjects and in patients with primary biliary cirrhosis and Wilson's disease.
Academic Article Epidemiology and clinical course of liver diseases: identification of candidates for hepatic transplantation.
Academic Article The role of the immune response in the pathogenesis of primary biliary cirrhosis.
Academic Article Abnormal hepatic transport of indocyanine green in Gilbert's syndrome.
Academic Article Relationship of pretransplant hepatobiliary disease to bile duct damage occurring in the liver allograft.
Academic Article Hepatic injury by prescription medication.
Academic Article Copper metabolism in primary biliary cirrhosis.
Academic Article Receptor specific clearance by the reticuloendothelial system in chronic liver diseases. Demonstration of defective C3b-specific clearance in primary biliary cirrhosis.
Academic Article Portal vein patency in candidates for liver transplantation: MR angiographic analysis.
Academic Article Acute liver failure due to lymphoma. A diagnostic concern when considering liver transplantation.
Academic Article Disappearing intrahepatic bile ducts: the syndromes and their mechanisms.
Academic Article Tacrolimus (FK 506) for rescue of chronic rejection following orthotopic liver transplantation.
Academic Article Acute hepatitis associated with the Chinese herbal product jin bu huan.
Academic Article Treatment of the postoperative alcoholic liver transplant recipient with other addictions.
Academic Article Comparison of histopathology in acute allograft rejection and recurrent hepatitis C infection after liver transplantation.
Academic Article Cyclosporine therapy in patients with steroid resistant autoimmune hepatitis.
Academic Article Hepatitis B virus S mutants in liver transplant recipients who were reinfected despite hepatitis B immune globulin prophylaxis.
Academic Article Posttransplantation: future therapies.
Academic Article Immune disorders of the liver and bile duct.
Academic Article Suppressor function of liver mononuclear cells isolated during murine chronic graft-vs-host disease. II. Role of prostaglandins and interferon-gamma.
Academic Article Hepatitis C virus is not recoverable from liver tissue in cryptogenic cirrhosis: failure to identify hepatitis C virus-RNA using reverse transcription-mediated polymerase chain reaction.
Academic Article Immunologic mechanisms of hepatic allograft rejection.
Academic Article Treatment of acetaminophen-induced fulminant hepatic failure with a bioartificial liver.
Academic Article Introduction to hepatitis B transplantation.
Academic Article Immunology of acute and chronic hepatic allograft rejection.
Academic Article Overview of hepatitis B and transplantation in the hepatitis B patient.
Academic Article 6-thioguanine can cause serious liver injury in inflammatory bowel disease patients.
Academic Article Successful liver transplantation following medical management of portopulmonary hypertension: a single-center series.
Academic Article The clinical and immunologic impact of using interferon and ribavirin in the immunosuppressed host.
Academic Article Waitlist mortality decreases with increased use of extended criteria donor liver grafts at adult liver transplant centers.
Academic Article Immunology and the liver.
Academic Article Disappearing bile ducts: immunologic mechanisms.
Academic Article Sirolimus-induced hyperlipidaemia in liver transplant recipients is not dose-dependent.
Academic Article Limited role for CXC chemokines in the pathogenesis of alpha-naphthylisothiocyanate-induced liver injury.
Academic Article Morbidity in live liver donors: standards-based adverse event reporting further refined.
Academic Article Crohn's ileitis after liver transplantation from a living related donor with Crohn's disease.
Academic Article Early hepatic nodular hyperplasia and submicroscopic fibrosis associated with 6-thioguanine therapy in inflammatory bowel disease.
Academic Article Management of patients with cirrhosis in Southern California: results of a practitioner survey.
Academic Article Imatinib (Gleevec)-induced hepatotoxicity.
Academic Article Hepatitis C virus viral assays in the direct-acting antiviral era.
Academic Article Efficacy and safety of boceprevir plus peginterferon-ribavirin in patients with HCV G1 infection and advanced fibrosis/cirrhosis.
Academic Article Suspected and unsuspected factors in the multifaceted immunopathology of viral hepatitis.
Academic Article In vitro cell-mediated cytotoxicity in primary biliary cirrhosis and chronic hepatitis. Dysfunction of spontaneous cell-mediated cytotoxicity in primary biliary cirrhosis.
Academic Article Comparison of the applicability of two prognostic scoring systems in patients with fulminant hepatic failure.
Academic Article The immunology of hepatitis B.
Academic Article Justice, administrative law, and the transplant clinician: the ethical and legislative basis of a national policy on donor liver allocation.
Academic Article An overview of emerging therapies for the treatment of chronic hepatitis C.
Academic Article Chronic hepatitis C genotype 1 patients with insulin resistance treated with pioglitazone and peginterferon alpha-2a plus ribavirin.
Academic Article HIV infection and the liver: the importance of HCV-HIV coinfection and drug-induced liver injury.
Academic Article Acute liver failure.
Academic Article The role of biliary epithelial cells in the immunopathogenesis of non-suppurative destructive cholangitis in murine hepatic graft-versus-host disease.
Academic Article Biochemical and immunologic effects of rituximab in patients with primary biliary cirrhosis and an incomplete response to ursodeoxycholic acid.
Academic Article Liver transplantation in autoimmune liver diseases.
Academic Article Hepatic lesions in murine chronic graft-versus-host disease to minor histocompatibility antigens. A reproducible model of nonsuppurative destructive cholangitis.
Academic Article Histopathology of early and late human hepatic allograft rejection: evidence of progressive destruction of interlobular bile ducts.
Academic Article Effect of splenectomy of hepatic bilirubin clearance in patients with hereditary spherocytosis. Implications for the diagnosis of Gilbert's syndrome.
Academic Article Transjugular intrahepatic portosystemic shunt: efficacy for the treatment of portal hypertension and impact on liver transplantation.
Academic Article Morbidity and mortality of recurrent hepatitis C infection after orthotopic liver transplantation.
Academic Article Malignant vascular tumors of the liver presenting as liver failure and portal hypertension.
Academic Article Recurrence of viral hepatitis after liver transplantation: insights into management.
Academic Article Up-regulation of intercellular adhesion molecule 1 transcription by hepatitis B virus X protein.
Academic Article Mycotic aneurysm of arterial conduit presenting as massive upper gastrointestinal hemorrhage after liver transplantation.
Academic Article Case studies of the hepatitis B patient: a panel discussion.
Academic Article Autoimmune cholangiopathy.
Academic Article Transmission of hepatitis B infection from hepatitis B core antibody--positive liver allografts is prevented by lamivudine therapy.
Academic Article Primary biliary cirrhosis and autoimmune cholangiopathy.
Academic Article Suppressor function of hepatic mononuclear inflammatory cells during murine chronic graft-vs-host disease. I. Macrophage-enriched cells mediate suppression in the liver.
Academic Article Future Treatment Options in PBC.
Academic Article Etiopathogenesis of primary sclerosing cholangitis.
Academic Article Living donor liver transplantation: histological abnormalities found on liver biopsies of apparently healthy potential donors.
Academic Article Model for end-stage liver disease (MELD) exception guidelines: results and recommendations from the MELD Exception Study Group and Conference (MESSAGE) for the approval of patients who need liver transplantation with diseases not considered by the standard MELD formula.
Academic Article Quality of life and everyday activities in patients with primary biliary cirrhosis.
Academic Article Interaction of CD44 and hyaluronic acid enhances biliary epithelial proliferation in cholestatic livers.
Academic Article Diagnosis and management of autoimmune hepatitis.
Academic Article Hepatic homing of mononuclear inflammatory cells isolated during murine chronic graft-vs-host disease.
Academic Article Diagnosis and treatment of autoimmune hepatitis.
Concept Liver Diseases
Concept Liver Cirrhosis
Concept Liver
Concept Liver, Artificial
Concept Liver Cirrhosis, Biliary
Concept Liver Function Tests
Concept Liver Transplantation
Concept Liver Cirrhosis, Alcoholic
Concept Chemical and Drug Induced Liver Injury
Concept Liver Failure
Concept Fatty Liver
Concept Liver Failure, Acute
Concept Liver Diseases, Alcoholic
Concept Mitochondria, Liver
Concept Liver Neoplasms
Academic Article Haemophagocytic lymphohistiocytosis presenting as liver failure following Epstein-Barr and prior hepatitis A infections.
Academic Article Elevated phenylacetic acid levels do not correlate with adverse events in patients with urea cycle disorders or hepatic encephalopathy and can be predicted based on the plasma PAA to PAGN ratio.
Academic Article Genetics of drug-induced hepatotoxicity toxicity in Gilbert's syndrome.
Academic Article Overall safety profile of boceprevir plus peginterferon alfa-2b and ribavirin in patients with chronic hepatitis C genotype 1: a combined analysis of 3 phase 2/3 clinical trials.
Academic Article Management of HBV Infection in Liver Transplantation Patients.
Academic Article Long-term follow-up of portopulmonary hypertension patients after liver transplantation.
Academic Article Development and validation of insulin-like growth factor-1 score to assess hepatic reserve in hepatocellular carcinoma.
Academic Article Safety and efficacy of boceprevir/peginterferon/ribavirin for HCV G1 compensated cirrhotics: meta-analysis of 5 trials.
Academic Article Daclatasvir in combination with asunaprevir and beclabuvir for hepatitis C virus genotype 1 infection with compensated cirrhosis.
Academic Article Autoimmune hepatitis.
Academic Article Legal Responsibilities of Physicians When They Diagnose Hepatic Encephalopathy.
Academic Article Autoimmune Hepatitis and Overlap Syndromes: Diagnosis and Management.
Academic Article Changing nomenclature for PBC: From 'cirrhosis' to 'cholangitis'.
Academic Article Changing nomenclature for PBC: from 'cirrhosis' to 'cholangitis'.
Academic Article Changing nomenclature for PBC: from 'cirrhosis' to 'cholangitis'.
Academic Article Changing nomenclature for PBC: From 'cirrhosis' to 'cholangitis'.
Academic Article Changing Nomenclature for PBC: From 'Cirrhosis' to 'Cholangitis'.
Academic Article Changing Nomenclature for PBC: From 'Cirrhosis' to 'Cholangitis'.
Academic Article Changing nomenclature for PBC: From 'cirrhosis' to 'cholangitis'.
Academic Article Changing nomenclature for PBC: From 'cirrhosis' to 'cholangitis'.
Academic Article Fasting Blood Ammonia Predicts Risk and Frequency of Hepatic Encephalopathy Episodes in Patients With Cirrhosis.
Academic Article Daclatasvir with sofosbuvir and ribavirin for hepatitis C virus infection with advanced cirrhosis or post-liver transplantation recurrence.
Academic Article Cutting edge issues in autoimmune hepatitis.
Academic Article Autoimmune liver diseases in the Asia-Pacific region: Proceedings of APASL symposium on AIH and PBC 2016.
Academic Article A Surge in cadaveric liver donors and a national narcotic epidemic: Is there an association?
Academic Article Prospective Multicenter Observational Study of Overt Hepatic Encephalopathy.
Academic Article Sofosbuvir, Velpatasvir, and Voxilaprevir for Previously Treated HCV Infection.
Academic Article Seladelpar (MBX-8025), a selective PPAR-d agonist, in patients with primary biliary cholangitis with an inadequate response to ursodeoxycholic acid: a double-blind, randomised, placebo-controlled, phase 2, proof-of-concept study.
Academic Article Liver transplant length of stay (LOS) index: A novel predictive score for hospital length of stay following liver transplantation.
Academic Article Unique metabolomic signature associated with hepatorenal dysfunction and mortality in cirrhosis.
Academic Article Safety and efficacy of a fixed-dose combination regimen of grazoprevir, ruzasvir, and uprifosbuvir with or without ribavirin in participants with and without cirrhosis with chronic hepatitis C virus genotype 1, 2, or 3 infection (C-CREST-1 and C-CREST-2, part B): two randomised, phase 2, open-label trials.
Academic Article Twenty-Year Comparative Analysis of Patients With Autoimmune Liver Diseases on Transplant Waitlists.
Academic Article Cystatin C Is a Gender-Neutral Glomerular Filtration Rate Biomarker in Patients with Cirrhosis.
Academic Article The safety and efficacy of elbasvir and grazoprevir in participants with hepatitis C virus genotype 1b infection.
Academic Article Predicting Liver Allograft Discard: The Discard Risk Index.
Academic Article No Gains in Long-term Survival After Liver Transplantation Over the Past Three Decades.
Academic Article Autoimmune hepatitis.
Grant HEPATIC LESIONS IN MURINE CHRONIC GRAFT VS HOST DISEASE
Grant HEPATIC LESIONS IN MURINE CHRONIC GRAFT-VS-HOST DISEASE
Academic Article Clinical presentation and natural history of autoimmune hepatitis.
Academic Article Therapeutic trials of biologics in primary biliary cholangitis: An open label study of abatacept and review of the literature.
Concept End Stage Liver Disease
Concept Non-alcoholic Fatty Liver Disease
Academic Article The Observer Effect in Liver Transplantation Exemplified by Unintended Consequences of Regulation and Selected Outcome Metrics.
Academic Article Immunopathogenesis: Insights for current and future therapies.
Academic Article The challenges of primary biliary cholangitis: What is new and what needs to be done.
Academic Article Diagnosis and Management of Autoimmune Hepatitis in Adults and Children: 2019 Practice Guidance and Guidelines From the American Association for the Study of Liver Diseases.
Academic Article A learning curve in using orphan liver allografts for transplantation.
Academic Article Aggressive utilization of liver allografts: Improved outcomes over time.
Academic Article Combined Lung-Liver and Delayed Kidney Transplantation for Cystic Fibrosis Clinical Approach and Outcome: A Case Report.
Academic Article Immunosuppressive Treatment Regimens in Autoimmune Hepatitis: Systematic Reviews and Meta-Analyses Supporting American Association for the Study of Liver Diseases Guidelines.
Academic Article Best practices for detection, assessment and management of suspected immune-mediated liver injury caused by immune checkpoint inhibitors during drug development.
Academic Article Trends in Outcomes for Marginal Allografts in Liver Transplant.
Academic Article Presentation and Outcomes of Autoimmune Hepatitis Type 1 and Type 2 in Children: A Single-center Study.
Academic Article Trends in Outcomes for Marginal Allografts in Liver Transplant.
Academic Article A randomized placebo-controlled trial of elafibranor in patients with primary biliary cholangitis and incomplete response to UDCA.
Academic Article Donor Gamma-Glutamyl Transferase Is Associated With Liver Allograft Discard and Failure.
Academic Article Practical Consideration for Drug Monitoring of Tacrolimus in Liver Transplantation Recipients with SARS-CoV-2 Infection.
Academic Article Screening for undiagnosed non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH): A population-based risk factor assessment using vibration controlled transient elastography (VCTE).
Academic Article Early Impact of MMaT-3 Policy on Liver Transplant Waitlist Outcomes for Hepatocellular Carcinoma.
Academic Article Prevalence and clinical significance of portal inflammation, portal plasma cells, interface hepatitis and biliary injury in liver biopsies from patients with non-alcoholic steatohepatitis.
Academic Article Single Topic Conference on Autoimmune Liver Disease from the Canadian Association for the Study of the Liver.
Academic Article Nomenclature, diagnosis and management of drug-induced autoimmune-like hepatitis (DI-ALH): An expert opinion meeting report.
Academic Article Open-label, clinical trial extension: Two-year safety and efficacy results of seladelpar in patients with primary biliary cholangitis.
Academic Article Efficacy and Safety of Elafibranor in Primary Biliary Cholangitis.
Academic Article Editorial: The evolving paradigms and treatments for primary biliary cholangitis-Authors' reply.
Academic Article A Phase 3 Trial of Seladelpar in Primary Biliary Cholangitis.
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  • Liver