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One or more keywords matched the following properties of KOSTEN, THOMAS
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overview Following a successful 25 year tenure as professor and chief of Psychiatry at Yale University and VA Connecticut, Dr. Kosten joined the Michael E. DeBakey Veterans Affairs Medical Center (MEDVAMC) in July 2006, bringing over 30 years of exemplary Federal service; the majority of which has been with the Department of Veterans Affairs. Over the period 2006-2011, Dr. Kosten served as the Research Director of the VA national Substance Use Disorders Quality Enhancement Research Initiative (QUERI) program, fully revitalizing a research-to-practice implementation program to provide proven, cutting-edge treatment to improve the lives of veteran populations across the VA health care system. With a joint appointment at Baylor College of Medicine (BCM), Dr. Kosten is the JH Waggoner Chair & Professor of Psychiatry, Pharmacology, Neuroscience and Immunology & Pathology. He is also vice-Chair for Psychiatry and Co-director of the Dan L. Duncan Institute for Clinical and Translational Research (ICTR) at Baylor College of Medicine. His other key appointments are Distinguished Professor of Psychiatry at Peking University Medical School and Professor of Epidemiology and of Behavioral Sciences at MD Anderson Cancer Prevention Center. He established the Division of Addictions Psychiatry at Baylor and Yale and directs their NIH Medications Development Center for substance abuse. A recognized leader in clinical and translational sciences, Dr. Kosten is a recent past recipient of a Research Scientist Award (1987-2010) from the National Institute of Health (NIH), he has served on national and international review groups for medications and vaccines development in substance abuse, and is credited with the development of several cutting-edge discoveries in medications for addictions. A former Congressional Fellow in the House of Representatives, Dr. Kosten has held visiting professorships in Germany, Spain, Greece, China and Canada. He is the founding vice-chair for Added Qualifications in Addiction Psychiatry of the American Board of Psychiatry and Neurology. He is a distinguished fellow in the American Psychiatric Association and fellow of the American College of Neuropsychopharmacology, past president of the American Academy of Addiction Psychiatry, and past president of the College on Problems of Drug Dependence (CPDD). He has received several prestigious awards for clinical research and for his work in vaccine pharmacotherapy for drug addictions, particularly in treating cocaine, methamphetamine, and opiate addictions. He is the current Editor for the American Journal on Addictions, past Editor for the American Journal of Drug and Alcohol Abuse, and serves on the board of several notable journals in substance abuse. Additionally, Dr. Kosten retains ongoing recognition in the Best Doctors in America® ranking, an honor reserved by only 5% of the nation’s doctors. As of 2012, for the 12th year in a row, he has been named by U.S. News & World Report as a Top Doc®, ranking him among the top 10% of psychiatrists in the region, and for the 9th consecutive year, in the top 1% of psychiatrists in the field of Addictions Medicine. He is a much sought-after expert both nationally and internationally in the field of addictions with appearances on National Geographic, Discovery Channel, and PBS as well as print, radio, and online publications that include WIRED, NPR, and the Wall Street Journal, among others. Dr. Kosten’s recent work includes serving on the National Academy of Sciences, Institute of Medicine (IOM) committee on vaccines for substance abuse. He also served on the recently concluded IOM’s Committee on Prevention, Diagnosis, Treatment, and Management of Substance Use Disorders in the U.S. Armed Forces, a congressional mandate via the National Defense Authorization Act for Fiscal Year 2010 (Public Law 111-84), to conduct an independent study on substance use disorders in the military. From his studies in substance dependence, post-traumatic stress disorder, and neuroimaging he has published over 600 papers, books and reviews. His medication contributions include a cocaine vaccine, immunotherapy for hallucinogens, buprenorphine for opioid dependence, disulfiram for cocaine dependence, vasodilators for cocaine induced cerebral perfusion defects, and combining medications with contingency management for opioid and cocaine dependence.
One or more keywords matched the following items that are connected to KOSTEN, THOMAS
Item TypeName
Academic Article Role of opioid antagonists in treating intravenous cocaine abuse.
Academic Article Rapid death during cocaine abuse: a variant of the neuroleptic malignant syndrome?
Academic Article Diagnosing depression with the DST and TRH in cocaine and opioid abusers.
Academic Article Abuse of cocaine with opioids: psychological aspects of treatment.
Academic Article Antecedents and consequences of cocaine abuse among opioid addicts. A 2.5-year follow-up.
Academic Article Cocaine abuse among opioid addicts: demographic and diagnostic factors in treatment.
Academic Article A preliminary study of desipramine in the treatment of cocaine abuse in methadone maintenance patients.
Academic Article Differences between responders and nonresponders to cocaine cues in the laboratory.
Academic Article Platelet alpha-granule release in cocaine users.
Academic Article Cocaine abuse in methadone maintenance programs: integrating pharmacotherapy with psychosocial interventions.
Academic Article A single-blind investigation of four auricular needle puncture configurations.
Academic Article Tryptophan depletion and attenuation of cue-induced craving for cocaine.
Academic Article Reduction of opiate withdrawal-like symptoms by cocaine abuse during methadone and buprenorphine maintenance.
Academic Article Effects of sham and real auricular needling: implications for trials of acupuncture for cocaine addiction.
Academic Article Clinical and research perspectives on cocaine abuse: the pharmacotherapy of cocaine abuse.
Academic Article Noradrenergic dysregulation during discontinuation of cocaine use in addicts.
Academic Article Acupuncture for the treatment of cocaine addiction. Investigation of a needle puncture control.
Academic Article Serotonergic mechanisms of cocaine effects in humans.
Academic Article Abstinence symptomatology associated with cessation of chronic cocaine abuse among methadone-maintained patients.
Academic Article Acute cocaine effects on absolute cerebral blood flow.
Academic Article Prognostic factors in Buprenorphine- versus methadone-maintained patients.
Academic Article Addiction as a brain disease.
Academic Article Alcohol and cocaine abuse. A comparison of epidemiology and clinical characteristics.
Academic Article Disulfiram effects on acute cocaine administration.
Academic Article Effects of d-amphetamine and caffeine in humans under a cocaine discrimination procedure.
Academic Article Changes concurrent with initiation of abstinence from cocaine abuse.
Academic Article Chronic disulfiram treatment effects on intranasal cocaine administration: initial results.
Academic Article Gender differences in cocaine use and treatment response.
Academic Article Pharmacotherapy for cocaine-abusing methadone-maintained patients using amantadine or desipramine.
Academic Article The pharmacotherapy of relapse prevention using anticonvulsants.
Academic Article Concurrent use of cocaine and alcohol is more potent and potentially more toxic than use of either alone--a multiple-dose study.
Academic Article Disulfiram versus placebo for cocaine dependence in buprenorphine-maintained subjects: a preliminary trial.
Academic Article Elevated central serotonin transporter binding availability in acutely abstinent cocaine-dependent patients.
Academic Article Significant interaction between clozapine and cocaine in cocaine addicts.
Academic Article A randomized controlled trial of auricular acupuncture for cocaine dependence.
Academic Article Gender differences in response to intranasal cocaine administration to humans.
Academic Article Interactions of cocaine with nimodipine: a brief report.
Academic Article Decreased digital flow persists after the abatement of cocaine-induced hemodynamic stimulation.
Academic Article Effect of alpha-methyl-para-tyrosine on response to cocaine challenge.
Academic Article Motivational factors in cocaine pharmacotherapy trials with methadone-maintained patients: problems and paradoxes.
Academic Article Thrice-weekly versus daily buprenorphine maintenance.
Academic Article A preliminary investigation of lamotrigine for cocaine abuse in HIV-seropositive patients.
Academic Article Current concepts in pharmacotherapy of substance abuse.
Academic Article Pharmacotherapy of cerebral ischemia in cocaine dependence.
Academic Article Quantitative medial temporal lobe brain morphology and hypothalamic-pituitary-adrenal axis function in cocaine dependence: a preliminary report.
Academic Article A comprehensive pharmacologic-psychosocial treatment program for HIV-seropositive cocaine- and opioid-dependent patients. Preliminary findings.
Academic Article [123I]beta-CIT SPECT imaging of dopamine transporter availability after mazindol administration in human cocaine addicts.
Academic Article Desipramine in opioid-dependent cocaine abusers maintained on buprenorphine vs methadone.
Academic Article Dopaminergic responsivity during cocaine abstinence: a pilot study.
Academic Article A randomized trial of buprenorphine maintenance for heroin dependence in a primary care clinic for substance users versus a methadone clinic.
Academic Article Aspirin or amiloride for cerebral perfusion defects in cocaine dependence.
Academic Article Effects of naltrexone and isradipine, alone or in combination, on cocaine responses in humans.
Academic Article Comorbid major depressive disorder as a prognostic factor in cocaine-abusing buprenorphine-maintained patients treated with desipramine and contingency management.
Academic Article Disulfiram facilitates the development and expression of locomotor sensitization to cocaine in rats.
Academic Article Cerebral perfusion defects in combined cocaine and alcohol dependence.
Academic Article Buprenorphine for cocaine and opiate dependence.
Academic Article Pharmacological approaches to cocaine dependence.
Academic Article Quantitative morphology of the caudate and putamen in patients with cocaine dependence.
Academic Article Going from the bedside back to the bench with ecopipam: a new strategy for cocaine pharmacotherapy development.
Academic Article Office-based treatment for opioid dependence: reaching new patient populations.
Academic Article Efficacy of dose and contingency management procedures in LAAM-maintained cocaine-dependent patients.
Academic Article Human therapeutic cocaine vaccine: safety and immunogenicity.
Academic Article Ketoconazole increases cocaine and opioid use in methadone maintained patients.
Academic Article Mazindol treatment of cocaine abuse. A double-blind investigation.
Academic Article Utility of crossover designs in clinical trials: efficacy of desipramine vs. placebo in opioid-dependent cocaine abusers.
Academic Article Therapeutic vaccines for substance dependence.
Academic Article Clinical efficacy of gabapentin versus tiagabine for reducing cocaine use among cocaine dependent methadone-treated patients.
Academic Article Genetics of dopamine and its contribution to cocaine addiction.
Academic Article Therapeutic vaccines for substance dependence.
Academic Article Human laboratory and neuroimaging studies in substance use disorders: developing new treatment approaches.
Academic Article Preliminary study of buprenorphine and bupropion for opioid-dependent smokers.
Academic Article Novel approaches to the treatment of cocaine addiction.
Academic Article Platelet abnormalities associated with cerebral perfusion defects in cocaine dependence.
Academic Article Desipramine treatment for cocaine dependence in buprenorphine- or methadone-treated patients: baseline urine results as predictor of response.
Academic Article Drug users' adherence to a 6-month vaccination protocol: effects of motivational incentives.
Academic Article Vaccine pharmacotherapy for the treatment of cocaine dependence.
Academic Article Cue-induced brain activity changes and relapse in cocaine-dependent patients.
Academic Article Tiagabine affects the subjective responses to cocaine in humans.
Academic Article Six-month trial of bupropion with contingency management for cocaine dependence in a methadone-maintained population.
Academic Article Pharmacotherapy improves treatment outcome in depressed cocaine addicts.
Academic Article Sertraline delays relapse in recently abstinent cocaine-dependent patients with depressive symptoms.
Academic Article Sex differences in brain activation during stress imagery in abstinent cocaine users: a functional magnetic resonance imaging study.
Academic Article Novel pharmacotherapeutic treatments for cocaine addiction.
Academic Article Neural activity associated with stress-induced cocaine craving: a functional magnetic resonance imaging study.
Academic Article Cocaine symptoms are predicted by familial psychopathology.
Academic Article Cocaine withdrawal symptoms predict medication response in cocaine users.
Academic Article Progesterone effects on cocaine use in male cocaine users maintained on methadone: a randomized, double-blind, pilot study.
Academic Article Treatment outcome predictors for cocaine dependence.
Academic Article Treatment of patients with substance use disorders, second edition. American Psychiatric Association.
Academic Article Buprenorphine: beyond methadone?
Academic Article Medications development and the war on drugs: victims of the Gulf war?
Academic Article Sex differences in non-reinforced responding for cocaine.
Academic Article Neurobiology of abused drugs. Opioids and stimulants.
Academic Article The dependence syndrome concept as applied to alcohol and other substances of abuse.
Academic Article Evidence for altered desipramine disposition in methadone-maintained patients treated for cocaine abuse.
Academic Article Depressive symptoms during buprenorphine treatment of opioid abusers.
Academic Article Active immunotherapy for the Treatment of Cocaine Dependence.
Academic Article Vaccines against drug abuse.
Academic Article Noradrenergic a1 receptor antagonist treatment attenuates positive subjective effects of cocaine in humans: a randomized trial.
Academic Article Probing cocaine-antibody interactions in buffer and human serum.
Academic Article Epigenetics of drug abuse: predisposition or response.
Academic Article The impact of disulfiram treatment on the reinforcing effects of cocaine: a randomized clinical trial.
Academic Article Cocaine abuse and opioid withdrawal.
Academic Article The MTHFR C677T Variant is Associated with Responsiveness to Disulfiram Treatment for Cocaine Dependency.
Academic Article Spontaneous development of IgM anti-cocaine antibodies in habitual cocaine users: effect on IgG antibody responses to a cocaine cholera toxin B conjugate vaccine.
Academic Article Buprenorphine treatment of cocaine abuse.
Academic Article Pharmacotherapeutic interventions for cocaine abuse. Matching patients to treatments.
Academic Article Desipramine facilitation of initial cocaine abstinence.
Academic Article Double-blind evaluation of the effect of acute amantadine on cocaine craving.
Academic Article DBH gene as predictor of response in a cocaine vaccine clinical trial.
Academic Article The dependence syndrome across different psychoactive substances: revised DSM-III.
Academic Article Differential diagnosis of psychiatric comorbidity in substance abusers.
Academic Article A 2.5-year follow-up of cocaine use among treated opioid addicts. Have our treatments helped?
Academic Article Cocaethylene: pharmacology, physiology and behavioral effects in humans.
Academic Article Behavioral, physiological, and pharmacological interaction of cocaine and disulfiram in humans.
Academic Article Stimulant withdrawal.
Academic Article HIV infection and cocaine use in methadone maintained and untreated intravenous drug users.
Academic Article Concurrent cocaine-ethanol ingestion in humans: pharmacology, physiology, behavior, and the role of cocaethylene.
Academic Article Cue-elicited cocaine craving and autogenic relaxation. Association with treatment outcome.
Academic Article Buprenorphine: dose-related effects on cocaine and opioid use in cocaine-abusing opioid-dependent humans.
Academic Article Mazindol treatment for cocaine dependence.
Academic Article Mazindol for relapse prevention to cocaine abuse in methadone-maintained patients.
Academic Article A multicenter trial of bupropion for cocaine dependence in methadone-maintained patients.
Academic Article Desipramine, amantadine, or fluoxetine in buprenorphine-maintained cocaine users.
Academic Article Pemoline for the treatment of cocaine dependence in methadone-maintained patients.
Academic Article Pharmacotherapy for opioid and cocaine abuse.
Academic Article Buprenorphine vs methadone maintenance treatment for concurrent opioid dependence and cocaine abuse.
Academic Article Association between self-report of cognitive impairment, HIV status, and cocaine use in a sample of cocaine-dependent methadone-maintained patients.
Academic Article Plasma homovanillic acid and the dopamine transporter during cocaine withdrawal.
Academic Article Elevated striatal dopamine transporters during acute cocaine abstinence as measured by [123I] beta-CIT SPECT.
Academic Article Regional cerebral blood flow during acute and chronic abstinence from combined cocaine-alcohol abuse.
Academic Article Individual differences in humans responding under a cocaine discrimination procedure: discriminators versus nondiscriminators.
Academic Article Neurobiological adaptations to psychostimulants and opiates as a basis of treatment development.
Academic Article Sex differences in self-reported and physiological response to oral cocaine and placebo in humans.
Academic Article Effects of cocaine prior to and during bupropion maintenance in cocaine-abusing volunteers.
Academic Article Tiagabine increases cocaine-free urines in cocaine-dependent methadone-treated patients: results of a randomized pilot study.
Academic Article Prediction of treatment outcome by baseline urine cocaine results and self-reported cocaine use for cocaine and opioid dependence.
Academic Article Gender-specific vulnerability for rCBF abnormalities among cocaine abusers.
Academic Article Effects of progesterone treatment on cocaine responses in male and female cocaine users.
Academic Article Depression as a prognostic factor for pharmacological treatment of cocaine dependence.
Academic Article Methadone versus buprenorphine with contingency management or performance feedback for cocaine and opioid dependence.
Academic Article Cortical excitability in cocaine-dependent patients: a replication and extension of TMS findings.
Academic Article The effect of alcohol on the neuropsychological functioning of recently abstinent cocaine-dependent subjects.
Academic Article Antisocial personality and stress-induced brain activation in cocaine-dependent patients.
Academic Article Emerging pharmacological strategies in the fight against cocaine addiction.
Academic Article Clinical efficacy of citalopram alone or augmented with bupropion in methadone-stabilized patients.
Academic Article Performance of cocaine dependent individuals and controls on a response inhibition task with varying levels of difficulty.
Academic Article Vaccines for cocaine abuse.
Academic Article Pharmacogenetic treatments for drug addiction: cocaine, amphetamine and methamphetamine.
Academic Article Cocaine vaccine for the treatment of cocaine dependence in methadone-maintained patients: a randomized, double-blind, placebo-controlled efficacy trial.
Academic Article Efficacy of opiate maintenance therapy and adjunctive interventions for opioid dependence with comorbid cocaine use disorders: A systematic review and meta-analysis of controlled clinical trials.
Academic Article Anti-cocaine vaccine development.
Academic Article Pharmacogenetic randomized trial for cocaine abuse: disulfiram and dopamine ?-hydroxylase.
Academic Article Effects of anti-cocaine vaccine and viral gene transfer of cocaine hydrolase in mice on cocaine toxicity including motor strength and liver damage.
Academic Article Anti-cocaine antibody and butyrylcholinesterase-derived cocaine hydrolase exert cooperative effects on cocaine pharmacokinetics and cocaine-induced locomotor activity in mice.
Academic Article Prospects, promise and problems on the road to effective vaccines and related therapies for substance abuse.
Academic Article ANKK1 and DRD2 pharmacogenetics of disulfiram treatment for cocaine abuse.
Academic Article Inpatient vs. outpatient cocaine abuse treatments.
Concept Crack Cocaine
Concept Cocaine
Concept Cocaine-Related Disorders
Academic Article The ?-opioid receptor gene as a predictor of response in a cocaine vaccine clinical trial.
Academic Article Vaccines against stimulants: cocaine and MA.
Academic Article Randomized clinical trial of disulfiram for cocaine dependence or abuse during buprenorphine treatment.
Academic Article Clinical efficacy of sertraline alone and augmented with gabapentin in recently abstinent cocaine-dependent patients with depressive symptoms.
Academic Article Vaccine for cocaine dependence: a randomized double-blind placebo-controlled efficacy trial.
Academic Article The influence of dopamine ?-hydroxylase gene polymorphism rs1611115 on levodopa/carbidopa treatment for cocaine dependence: a preliminary study.
Academic Article Hapten optimization for cocaine vaccine with improved cocaine recognition.
Academic Article The future potential for cocaine vaccines.
Academic Article Attenuation of cocaine-induced locomotor activity in male and female mice by active immunization.
Academic Article Emerging drugs for the treatment of cocaine use disorder: a review of neurobiological targets and pharmacotherapy.
Academic Article Genetic variation of the dopamine transporter (DAT1) influences the acute subjective responses to cocaine in volunteers with cocaine use disorders.
Academic Article Dopamine D3 receptor-preferring agonist enhances the subjective effects of cocaine in humans.
Academic Article Inhibitory behavioral control: A stochastic dynamic causal modeling study comparing cocaine dependent subjects and controls.
Academic Article The a-1 adrenoceptor (ADRA1A) genotype moderates the magnitude of acute cocaine-induced subjective effects in cocaine-dependent individuals.
Academic Article Pharmacogenetics of Dopamine ?-Hydroxylase in cocaine dependence therapy with doxazosin.
Academic Article Altered anterior cingulate cortex to hippocampus effective connectivity in response to drug cues in men with cocaine use disorder.
Academic Article Moderators of response to sertraline versus placebo among recently abstinent, cocaine dependent patients: A retrospective analysis of two clinical trials.
Academic Article FAAH variant Pro129Thr modulates subjective effects produced by cocaine administration.
Grant Cocaine Vaccine for Methadone Maintained Patients
Grant CLINICAL RESEARCH CENTER FOR OPIOID AND COCAINE ABUSE
Grant Stimulant Pharmacotherapy: Noradrenergic Targets
Grant Pharmacotherapy for opioid and cocaine dependence
Grant THERAPEUTIC COCAINE VACCINE
Grant Comorbidity in Cocaine and Opioid Pharmacotherapy
Grant REDUCING AIDS RISKS
Grant Multisite Controlled Trial of Cocaine Vaccine (1of 6) Lead Site/ Houston Treatmen
Grant Human methamphetamine vaccine: Translational Avante Garde Award
Grant YALE MEDICATIONS DEVELOPMENT RESEARCH CENTER
Grant PHARMACOTHERAPY OF IV COCAINE USE IN METHADONE PATIENTS
Grant Developing Immunotherapeutics for Methamphetamine Abuse
Grant COCAINE PHARMACOTHERAPIES FOR COMORBID POPULATIONS
Academic Article Pharmacogenetic role of dopamine transporter (SLC6A3) variation on response to disulfiram treatment for cocaine addiction.
Academic Article Doxazosin treatment in cocaine use disorder: pharmacogenetic response based on an alpha-1 adrenoreceptor subtype D genetic variant.
Academic Article Current status of immunotherapies for addiction.
Grant Complementary Combination Therapy for Cocaine Dependence
Academic Article The OPRD1 rs678849 variant influences outcome of disulfiram treatment for cocaine dependency in methadone-maintained patients.
Academic Article Current status of vaccines for substance use disorders: A brief review of human studies.
Academic Article Moderation of buprenorphine therapy for cocaine dependence efficacy by variation of the Prodynorphin gene.
Academic Article Anti-Cocaine IgA Rather Than IgG Mediates Vaccine Protection from Cocaine Use.
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