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Concept
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Mutagenesis, Site-Directed
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Concept
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Mutagenesis
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Academic Article
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Transplanted LDL and mannose-6-phosphate receptor internalization signals promote high-efficiency endocytosis of the transferrin receptor.
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Academic Article
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Altering the antigenicity of proteins.
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Academic Article
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Thermostabilization of recombinant human and bovine CuZn superoxide dismutases by replacement of free cysteines.
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Academic Article
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Transferrin receptor internalization sequence YXRF implicates a tight turn as the structural recognition motif for endocytosis.
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Academic Article
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Enzyme motifs in antibodies.
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Academic Article
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A role for acidic residues in di-leucine motif-based targeting to the endocytic pathway.
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Academic Article
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Identification of critical active-site residues in the multifunctional human DNA repair enzyme HAP1.
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Academic Article
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The role of arginine 143 in the electrostatics and mechanism of Cu,Zn superoxide dismutase: computational and experimental evaluation by mutational analysis.
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Academic Article
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Ligand-induced internalization of the epidermal growth factor receptor is mediated by multiple endocytic codes analogous to the tyrosine motif found in constitutively internalized receptors.
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Academic Article
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A mutation in the human cyclin-dependent kinase interacting protein, CksHs2, interferes with cyclin-dependent kinase binding and biological function, but preserves protein structure and assembly.
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Academic Article
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Human dUTP pyrophosphatase: uracil recognition by a beta hairpin and active sites formed by three separate subunits.
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Academic Article
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Glubodies: randomized libraries of glutathione transferase enzymes.
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Academic Article
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Human mitochondrial manganese superoxide dismutase polymorphic variant Ile58Thr reduces activity by destabilizing the tetrameric interface.
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Academic Article
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Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase.
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Academic Article
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A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA.
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Academic Article
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Function of the Greek key connection analysed using circular permutants of superoxide dismutase.
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Academic Article
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Crystal structure of Y34F mutant human mitochondrial manganese superoxide dismutase and the functional role of tyrosine 34.
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Academic Article
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Crystallographic structure reveals phosphorylated pilin from Neisseria: phosphoserine sites modify type IV pilus surface chemistry and fibre morphology.
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Academic Article
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Mutation of an active site residue in Escherichia coli uracil-DNA glycosylase: effect on DNA binding, uracil inhibition and catalysis.
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Academic Article
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Interrupting the hydrogen bond network at the active site of human manganese superoxide dismutase.
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Academic Article
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MutY catalytic core, mutant and bound adenine structures define specificity for DNA repair enzyme superfamily.
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Academic Article
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Human glutathione transferase A4-4 crystal structures and mutagenesis reveal the basis of high catalytic efficiency with toxic lipid peroxidation products.
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Academic Article
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DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination [corrected].
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Academic Article
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Exon 5 encoded domain is not required for the toxic function of mutant SOD1 but essential for the dismutase activity: identification and characterization of two new SOD1 mutations associated with familial amyotrophic lateral sclerosis.
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Academic Article
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Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base binding.
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Academic Article
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Inducible nitric oxide synthase: role of the N-terminal beta-hairpin hook and pterin-binding segment in dimerization and tetrahydrobiopterin interaction.
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Academic Article
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Multiple replacements of glutamine 143 in human manganese superoxide dismutase: effects on structure, stability, and catalysis.
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Academic Article
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Structural chemistry of a green fluorescent protein Zn biosensor.
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Academic Article
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Design of a monomeric human glutathione transferase GSTP1, a structurally stable but catalytically inactive protein.
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Academic Article
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Mechanism and energetics of green fluorescent protein chromophore synthesis revealed by trapped intermediate structures.
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Academic Article
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Catalytic and structural effects of amino acid substitution at histidine 30 in human manganese superoxide dismutase: insertion of valine C gamma into the substrate access channel.
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Academic Article
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Structural basis for isozyme-specific regulation of electron transfer in nitric-oxide synthase.
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Academic Article
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Interaction interface of human flap endonuclease-1 with its DNA substrates.
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Academic Article
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Role of hydrogen bonding in the active site of human manganese superoxide dismutase.
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Academic Article
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Reaction intermediates in the catalytic mechanism of Escherichia coli MutY DNA glycosylase.
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Academic Article
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Understanding GFP chromophore biosynthesis: controlling backbone cyclization and modifying post-translational chemistry.
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Academic Article
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Crystallographic structures of Discosoma red fluorescent protein with immature and mature chromophores: linking peptide bond trans-cis isomerization and acylimine formation in chromophore maturation.
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Academic Article
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Defining the role of arginine 96 in green fluorescent protein fluorophore biosynthesis.
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Academic Article
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A novel processive mechanism for DNA synthesis revealed by structure, modeling and mutagenesis of the accessory subunit of human mitochondrial DNA polymerase.
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Academic Article
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Understanding GFP posttranslational chemistry: structures of designed variants that achieve backbone fragmentation, hydrolysis, and decarboxylation.
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Academic Article
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The case of the missing ring: radical cleavage of a carbon-carbon bond and implications for GFP chromophore biosynthesis.
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Academic Article
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Repair of O4-alkylthymine by O6-alkylguanine-DNA alkyltransferases.
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Academic Article
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ATP induces conformational changes in the carboxyl-terminal region of ClC-5.
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Academic Article
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Structural tuning of the fluorescent protein iLOV for improved photostability.
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Academic Article
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Conserved structural chemistry for incision activity in structurally non-homologous apurinic/apyrimidinic endonuclease APE1 and endonuclease IV DNA repair enzymes.
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Academic Article
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Insights into FlaI functions in archaeal motor assembly and motility from structures, conformations, and genetics.
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Academic Article
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Structural insights into the interaction of IL-33 with its receptors.
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Academic Article
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Structural Control of Nonnative Ligand Binding in Engineered Mutants of Phosphoenolpyruvate Carboxykinase.
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