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DMITROVSKY, ETHAN

One or more keywords matched the following items that are connected to DMITROVSKY, ETHAN

Item Type	Name
Concept	Tretinoin
Concept	Receptors, Retinoic Acid
Academic Article	Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML.
Academic Article	Response and resistance to retinoic acid are mediated through the retinoic acid nuclear receptor gamma in human teratocarcinomas.
Academic Article	Retinoic acid and its rearranged receptor in the treatment of acute promyelocytic leukemia.
Academic Article	Detection of minimal residual disease in acute promyelocytic leukemia by a reverse transcription polymerase chain reaction assay for the PML/RAR-alpha fusion mRNA.
Academic Article	FGF4 dissociates anti-tumorigenic from differentiation signals of retinoic acid in human embryonal carcinomas.
Academic Article	Targeting of PML/RARalpha is lethal to retinoic acid-resistant promyelocytic leukemia cells.
Academic Article	Transcriptional activation of the cyclin-dependent kinase inhibitor p21 by PML/RARalpha.
Academic Article	Retinoid target genes in acute promyelocytic leukemia.
Academic Article	Tissue microarrays for hypothesis generation.
Academic Article	Nonclassical retinoids and lung carcinogenesis.
Academic Article	The retinoic acid paradox in cancer chemoprevention.
Academic Article	UBE1L represses PML/RAR{alpha} by targeting the PML domain for ISG15ylation.
Academic Article	G0S2 is an all-trans-retinoic acid target gene.
Academic Article	A retinoic acid-dependent checkpoint in the development of CD4+ T cell-mediated immunity.
Academic Article	Repression of exogenous gene expression by the retinoic acid target gene G0S2.
Academic Article	Retinoic acid and its rearranged receptor in the etiology and treatment of acute promyelocytic leukemia.
Academic Article	Active cancer therapy combining 13-cis-retinoic acid with interferon-alpha.
Academic Article	Novel retinoic acid receptor-alpha transcripts in acute promyelocytic leukemia responsive to all-trans-retinoic acid.
Academic Article	Retinoic acid causes a decline in TGF-alpha expression, cloning efficiency, and tumorigenicity in a human embryonal cancer cell line.
Academic Article	Overexpression of the retinoic acid receptor gamma directly induces terminal differentiation of human embryonal carcinoma cells.
Academic Article	Molecular biologic features of non-small cell lung cancer. Clinical implications.
Academic Article	A ribozyme which discriminates in vitro between PML/RAR alpha, the t(15;17)-associated fusion RNA of acute promyelocytic leukemia, and PML and RAR alpha, the transcripts from the nonrearranged alleles.
Academic Article	CD2 expression and PML/RAR-alpha transcripts in acute promyelocytic leukemia.
Academic Article	Retinoic acid stimulates the protein kinase C pathway before activation of its beta-nuclear receptor during human teratocarcinoma differentiation.
Academic Article	9-cis and all-trans retinoic acid induce a similar phenotype in human teratocarcinoma cells.
Academic Article	Telomerase activity is repressed during differentiation of maturation-sensitive but not resistant human tumor cell lines.
Academic Article	Inhibited transformation of immortalized human bronchial epithelial cells by retinoic acid is linked to cyclin E down-regulation.
Academic Article	4HPR triggers apoptosis but not differentiation in retinoid sensitive and resistant human embryonal carcinoma cells through an RARgamma independent pathway.
Academic Article	Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation.
Academic Article	Microarray analyses uncover UBE1L as a candidate target gene for lung cancer chemoprevention.
Academic Article	Retinoid targeting of different D-type cyclins through distinct chemopreventive mechanisms.
Academic Article	Repression of cyclin D1 as a target for germ cell tumors.
Academic Article	A retinoic acid--rich tumor microenvironment provides clonal survival cues for tumor-specific CD8(+) T cells.
Academic Article	Continuous treatment with all-trans retinoic acid causes a progressive reduction in plasma drug concentrations: implications for relapse and retinoid "resistance" in patients with acute promyelocytic leukemia.
Academic Article	Reverse transcription polymerase chain reaction for the rearranged retinoic acid receptor alpha clarifies diagnosis and detects minimal residual disease in acute promyelocytic leukemia.
Academic Article	Growth factors in human germ cell cancer.
Academic Article	Retinoic acid induces down-regulation of several growth factors and proto-oncogenes in a human embryonal cancer cell line.
Academic Article	Retinoic acid stimulates protein kinase A-associated G proteins during human teratocarcinoma differentiation.
Academic Article	Pulsed-field gel electrophoresis analysis of retinoic acid receptor-alpha and promyelocytic leukemia rearrangements. Detection of the t(15;17) translocation in the diagnosis of acute promyelocytic leukemia.
Academic Article	Over-expression of transforming growth factor alpha antagonizes the anti-tumorigenic but not the differentiation actions of retinoic acid in a human teratocarcinoma cell.
Academic Article	Growth suppression of transformed human bronchial epithelial cells by all-trans-retinoic acid occurs through specific retinoid receptors.
Academic Article	Interferon augments PML and PML/RAR alpha expression in normal myeloid and acute promyelocytic cells and cooperates with all-trans retinoic acid to induce maturation of a retinoid-resistant promyelocytic cell line.
Academic Article	Posttranslational regulation of cyclin D1 by retinoic acid: a chemoprevention mechanism.
Academic Article	Common defects of different retinoic acid resistant promyelocytic leukemia cells are persistent telomerase activity and nuclear body disorganization.
Academic Article	Specific retinoid receptors cooperate to signal growth suppression and maturation of human embryonal carcinoma cells.
Academic Article	Expression of retinoic acid receptor beta in human renal cell carcinomas correlates with sensitivity to the antiproliferative effects of 13-cis-retinoic acid.
Academic Article	Retinoic acid promotes ubiquitination and proteolysis of cyclin D1 during induced tumor cell differentiation.
Academic Article	The retinoids and cancer prevention mechanisms.
Academic Article	Retinoic acid activates p53 in human embryonal carcinoma through retinoid receptor-dependent stimulation of p53 transactivation function.
Academic Article	Cyclin proteolysis as a retinoid cancer prevention mechanism.
Academic Article	Evidence for the epidermal growth factor receptor as a target for lung cancer prevention.
Academic Article	Involvement of UBE1L in ISG15 conjugation during retinoid-induced differentiation of acute promyelocytic leukemia.
Academic Article	Retinoic acid represses a cassette of candidate pluripotency chromosome 12p genes during induced loss of human embryonal carcinoma tumorigenicity.
Academic Article	Uncovering residues that regulate cyclin D1 proteasomal degradation.
Academic Article	Blockade of the ubiquitin protease UBP43 destabilizes transcription factor PML/RARa and inhibits the growth of acute promyelocytic leukemia.
Academic Article	The genetic and biologic aspects of treatment response and resistance in male germ cell cancer.
Academic Article	all-trans retinoic acid for treating germ cell tumors. In vitro activity and results of a phase II trial.
Academic Article	Transgenic expression of PML/RARalpha impairs myelopoiesis.
Academic Article	Derivation and characterization of retinoid-resistant human embryonal carcinoma cells.
Academic Article	Cloning of the human orphan receptor germ cell nuclear factor/retinoid receptor-related testis-associated receptor and its differential regulation during embryonal carcinoma cell differentiation.
Academic Article	Aberrant retinoid signaling and breast cancer: the view from outside the nucleus.
Academic Article	UBE1L is a retinoid target that triggers PML/RARalpha degradation and apoptosis in acute promyelocytic leukemia.
Academic Article	Microarray analysis uncovers retinoid targets in human bronchial epithelial cells.
Academic Article	Retinoids in cancer therapy and chemoprevention: promise meets resistance.
Academic Article	A novel retinoic acid receptor beta isoform and retinoid resistance in lung carcinogenesis.
Academic Article	Inhibiting retinoic acid signaling ameliorates graft-versus-host disease by modifying T-cell differentiation and intestinal migration.
Academic Article	Differentiation therapy of acute promyelocytic leukemia with tretinoin (all-trans-retinoic acid).
Academic Article	Acute promyelocytic leukemia: retinoic acid response and resistance.
Academic Article	Growth suppression of acute promyelocytic leukemia cells having increased expression of the non-rearranged alleles: RAR alpha or PML.
Academic Article	All-trans-retinoic acid and hexamethylene bisacetamide (HMBA) regulate TGF-alpha and Hst-1/kFGF expression in differentiation sensitive but not in resistant human teratocarcinomas.
Academic Article	Cooperation between retinoic acid and phorbol esters enhances human teratocarcinoma differentiation.
Academic Article	All-trans retinoic acid for acute promyelocytic leukemia. Results of the New York Study.
Academic Article	Specific chemopreventive agents trigger proteasomal degradation of G1 cyclins: implications for combination therapy.
Academic Article	Evidence for the ubiquitin protease UBP43 as an antineoplastic target.
Academic Article	All-trans-retinoic acid antagonizes the Hedgehog pathway by inducing patched.
Academic Article	Retinoids and rexinoids in cancer prevention: from laboratory to clinic.
Academic Article	CD38-Mediated Immunosuppression as a Mechanism of Tumor Cell Escape from PD-1/PD-L1 Blockade.
Concept	Retinoic Acid Receptor alpha
Academic Article	A novel retinoic acid receptor-? agonist antagonizes immune checkpoint resistance in lung cancers by altering the tumor immune microenvironment.

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Tretinoin