"Genetic Pleiotropy" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A phenomenon in which multiple and diverse phenotypic outcomes are influenced by a single gene (or single gene product.)
| Descriptor ID |
D058685
|
| MeSH Number(s) |
G05.420.556 G05.695.550
|
| Concept/Terms |
Genetic Pleiotropy- Genetic Pleiotropy
- Pleiotropy, Genetic
- Genetic Pleiotropism
- Pleiotropism, Genetic
Pleiotropic Gene- Pleiotropic Gene
- Gene, Pleiotropic
- Genes, Pleiotropic
- Pleiotropic Genes
|
Below are MeSH descriptors whose meaning is more general than "Genetic Pleiotropy".
Below are MeSH descriptors whose meaning is more specific than "Genetic Pleiotropy".
This graph shows the total number of publications written about "Genetic Pleiotropy" by people in this website by year, and whether "Genetic Pleiotropy" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2012 | 1 | 1 | 2 |
| 2013 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 0 | 2 | 2 |
| 2016 | 5 | 0 | 5 |
| 2017 | 1 | 0 | 1 |
| 2018 | 3 | 1 | 4 |
| 2019 | 2 | 1 | 3 |
| 2020 | 0 | 1 | 1 |
| 2021 | 1 | 1 | 2 |
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Below are the most recent publications written about "Genetic Pleiotropy" by people in Profiles.
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Genome-wide Association Study of Liver-related Enzymes Suggests Putative Pleiotropic Effects on Diverse Traits and Diseases. Hepatology. 2021 12; 74(6):3529-3533.
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Perturbations of genes essential for M?llerian duct and W?lffian duct development in Mayer-Rokitansky-K?ster-Hauser syndrome. Am J Hum Genet. 2021 02 04; 108(2):337-345.
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Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density. PLoS Genet. 2020 12; 16(12):e1009190.
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Genome analysis and pleiotropy assessment using causal networks with loss of function mutation and metabolomics. BMC Genomics. 2019 May 21; 20(1):395.
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Mendelian randomization evaluation of causal effects of fibrinogen on incident coronary heart disease. PLoS One. 2019; 14(5):e0216222.
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Exome Sequencing of Two Siblings with Sporadic Autism Spectrum Disorder and Severe Speech Sound Disorder Suggests Pleiotropic and Complex Effects. Behav Genet. 2019 07; 49(4):399-414.
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Assessing pleiotropy and mediation in genetic loci associated with chronic obstructive pulmonary disease. Genet Epidemiol. 2019 04; 43(3):318-329.
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Diagnostics for Pleiotropy in Mendelian Randomization Studies: Global and Individual Tests for Direct Effects. Am J Epidemiol. 2018 12 01; 187(12):2672-2680.
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Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways. Nat Commun. 2018 11 14; 9(1):4774.
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An Ancient Fecundability-Associated Polymorphism Creates a GATA2 Binding Site in a Distal Enhancer of HLA-F. Am J Hum Genet. 2018 10 04; 103(4):509-521.