"Endophenotypes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Measurable biological (physiological, biochemical, and anatomical features), behavioral (psychometric pattern) or cognitive markers that are found more often in individuals with a disease than in the general population. Because many endophenotypes are present before the disease onset and in individuals with heritable risk for disease such as unaffected family members, they can be used to help diagnose and search for causative genes.
| Descriptor ID |
D058068
|
| MeSH Number(s) |
G05.695.224
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Endophenotypes".
Below are MeSH descriptors whose meaning is more specific than "Endophenotypes".
This graph shows the total number of publications written about "Endophenotypes" by people in this website by year, and whether "Endophenotypes" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 1 | 1 | 2 |
| 2012 | 2 | 0 | 2 |
| 2014 | 1 | 1 | 2 |
| 2015 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
| 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Endophenotypes" by people in Profiles.
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Endophenotype effect sizes support variant pathogenicity in monogenic disease susceptibility genes. Nat Commun. 2022 08 30; 13(1):5106.
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Amygdala structure and function in paediatric bipolar disorder and high-risk youth: A systematic review of magnetic resonance imaging findings. World J Biol Psychiatry. 2022 Feb; 23(2):103-126.
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Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction. Nat Commun. 2020 05 21; 11(1):2542.
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Current trends in BPD research as indicative of a broader sea-change in psychiatric nosology. Personal Disord. 2016 10; 7(4):334-343.
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Genetic variation in melatonin pathway enzymes in children with autism spectrum disorder and comorbid sleep onset delay. J Autism Dev Disord. 2015 Jan; 45(1):100-10.
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Smoking, MATRICS consensus cognitive battery and P50 sensory gating in a Han Chinese population. Drug Alcohol Depend. 2014 Oct 01; 143:51-7.
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Impulsivity in children and adolescents with mood disorders and unaffected offspring of bipolar parents. Compr Psychiatry. 2014 Aug; 55(6):1337-41.
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Major depression in mothers predicts reduced ventral striatum activation in adolescent female offspring with and without depression. J Abnorm Psychol. 2014 May; 123(2):298-309.
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Lexical decision as an endophenotype for reading comprehension: an exploration of an association. Dev Psychopathol. 2012 Nov; 24(4):1345-60.
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Addictive disorders: finding the predisposing traits. Am J Psychiatry. 2012 Sep; 169(9):888-90.