Sodium-Hydrogen Exchanger 3
"Sodium-Hydrogen Exchanger 3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A sodium-hydrogen antiporter expressed primarily by EPITHELIAL CELLS in the kidneys, it localizes to the apical membrane of the PROXIMAL KIDNEY TUBULE, where it functions in sodium and water reabsorption and possibly calcium homeostasis. It also is expressed in heart, brain, and lung tissues and is resistant to AMILORIDE inhibition.
| Descriptor ID |
D000074083
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| MeSH Number(s) |
D12.776.157.530.450.162.775.750 D12.776.157.530.937.703.750 D12.776.543.550.190.775.750 D12.776.543.585.450.162.775.750 D12.776.543.585.937.828.750
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| Concept/Terms |
Sodium-Hydrogen Exchanger 3- Sodium-Hydrogen Exchanger 3
- Sodium Hydrogen Exchanger 3
- Na(+)-H(+) Exchanger 3
- Solute Carrier Family 9 Member 3
- NHE-3 Protein
- NHE 3 Protein
- SLC9A3 Protein
|
Below are MeSH descriptors whose meaning is more general than "Sodium-Hydrogen Exchanger 3".
Below are MeSH descriptors whose meaning is more specific than "Sodium-Hydrogen Exchanger 3".
This graph shows the total number of publications written about "Sodium-Hydrogen Exchanger 3" by people in this website by year, and whether "Sodium-Hydrogen Exchanger 3" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2011 | 0 | 2 | 2 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
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Below are the most recent publications written about "Sodium-Hydrogen Exchanger 3" by people in Profiles.
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Editing Myosin VB Gene to Create Porcine Model of Microvillus Inclusion Disease, With Microvillus-Lined Inclusions and Alterations in Sodium Transporters. Gastroenterology. 2020 06; 158(8):2236-2249.e9.
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Loss of MYO5B Leads to Reductions in Na+ Absorption With Maintenance of CFTR-Dependent Cl- Secretion in Enterocytes. Gastroenterology. 2018 12; 155(6):1883-1897.e10.
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Intestinal brush-border Na+/H+ exchanger-3 drives H+-coupled iron absorption in the mouse. Am J Physiol Gastrointest Liver Physiol. 2016 09 01; 311(3):G423-30.
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Colonic Mucosal Epigenome and Microbiome Development in Children and Adolescents. J Immunol Res. 2016; 2016:9170162.
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Restoration of Na+/H+ exchanger NHE3-containing macrocomplexes ameliorates diabetes-associated fluid loss. J Clin Invest. 2015 Sep; 125(9):3519-31.
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Human Clostridium difficile infection: inhibition of NHE3 and microbiota profile. Am J Physiol Gastrointest Liver Physiol. 2015 Mar 15; 308(6):G497-509.
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Loss of NHE3 alters gut microbiota composition and influences Bacteroides thetaiotaomicron growth. Am J Physiol Gastrointest Liver Physiol. 2013 Nov 15; 305(10):G697-711.
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Transcription factor Nrf2 protects renal dopamine D1 receptor function during oxidative stress. Hypertension. 2013 Sep; 62(3):512-7.
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Proximal tubule Na+/H+ exchanger activity in adult NHE8-/-, NHE3-/-, and NHE3-/-/NHE8-/- mice. Am J Physiol Renal Physiol. 2012 Dec 01; 303(11):F1495-502.
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Angiotensin II-mediated biphasic regulation of proximal tubular Na+/H+ exchanger 3 is impaired during oxidative stress. Am J Physiol Renal Physiol. 2011 Aug; 301(2):F364-70.