Interferon-Induced Helicase, IFIH1
"Interferon-Induced Helicase, IFIH1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A DEAD box RNA helicase that contains two N-terminal CASPASE ACTIVATION AND RECRUITMENT DOMAINS. It functions as a sensor of viral NUCLEIC ACIDS such as DOUBLE-STRANDED RNA and activates the INNATE IMMUNE RESPONSE by inducing the expression of INTERFERON-ALPHA and INTERFERON-BETA. It may also regulate cell growth and APOPTOSIS.
| Descriptor ID |
D000072640
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| MeSH Number(s) |
D08.811.913.696.445.735.720.249.875
|
| Concept/Terms |
Interferon-Induced Helicase, IFIH1- Interferon-Induced Helicase, IFIH1
- Helicase, IFIH1 Interferon-Induced
- IFIH1 Interferon-Induced Helicase
- Interferon Induced Helicase, IFIH1
- Helicard
- Melanoma Differentiation-Associated Protein 5
- Melanoma Differentiation Associated Protein 5
- CADM-140 Autoantigen
- Autoantigen, CADM-140
- CADM 140 Autoantigen
- Interferon Induced with Helicase C Domain 1
- Interferon-Induced Helicase C Domain-Containing Protein 1
- Interferon Induced Helicase C Domain Containing Protein 1
- IFIH1 Protein
|
Below are MeSH descriptors whose meaning is more general than "Interferon-Induced Helicase, IFIH1".
Below are MeSH descriptors whose meaning is more specific than "Interferon-Induced Helicase, IFIH1".
This graph shows the total number of publications written about "Interferon-Induced Helicase, IFIH1" by people in this website by year, and whether "Interferon-Induced Helicase, IFIH1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2012 | 0 | 2 | 2 |
| 2014 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
| 2021 | 2 | 2 | 4 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Interferon-Induced Helicase, IFIH1" by people in Profiles.
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Systemic complications of Aicardi Gouti?res syndrome using real-world data. Mol Genet Metab. 2024 Sep-Oct; 143(1-2):108578.
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Progressive, refractory macrophage activation syndrome as the initial presentation of anti-MDA5 antibody positive juvenile dermatomyositis: a case report and literature review. Pediatr Rheumatol Online J. 2022 Feb 22; 20(1):16.
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ADAR and hnRNPC deficiency synergize in activating endogenous dsRNA-induced type I IFN responses. J Exp Med. 2021 09 06; 218(9).
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IFIH1 loss-of-function variants contribute to very early-onset inflammatory bowel disease. Hum Genet. 2021 Sep; 140(9):1299-1312.
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Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell. Cell Rep. 2021 07 13; 36(2):109364.
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Risk factors associated with Pneumocystis jirovecii pneumonia in juvenile myositis in North America. Rheumatology (Oxford). 2021 02 01; 60(2):829-836.
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Distinct tissue injury patterns in juvenile dermatomyositis auto-antibody subgroups. Acta Neuropathol Commun. 2020 08 05; 8(1):125.
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Enterovirus 2Apro targets MDA5 and MAVS in infected cells. J Virol. 2014 Mar; 88(6):3369-78.
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Cardiac-specific overexpression of melanoma differentiation-associated gene-5 protects mice from lethal viral myocarditis. Circ Heart Fail. 2013 Mar; 6(2):326-34.
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Human respiratory syncytial virus nucleoprotein and inclusion bodies antagonize the innate immune response mediated by MDA5 and MAVS. J Virol. 2012 Aug; 86(15):8245-58.