"Lumican" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A small leucine-rich proteoglycan that contains 10 tandem leucine repeats and four N-linked sites within the leucine repeat region that may be substituted with KERATAN SULFATE. These properties and its horseshoe shape allow it to mediate interactions among COLLAGEN molecules within fibrils. It is expressed in most mesenchymal tissues as well as the CORNEA, where it functions to maintain transparency.
| Descriptor ID |
D000071234
|
| MeSH Number(s) |
D09.698.735.700.875 D12.776.395.650.875.750 D12.776.860.300.806.875
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Lumican".
Below are MeSH descriptors whose meaning is more specific than "Lumican".
This graph shows the total number of publications written about "Lumican" by people in this website by year, and whether "Lumican" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 0 | 2 | 2 |
| 2012 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2016 | 2 | 0 | 2 |
| 2017 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "Lumican" by people in Profiles.
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Hypoxia-induced autophagy of stellate cells inhibits expression and secretion of lumican into microenvironment of pancreatic ductal adenocarcinoma. Cell Death Differ. 2019 01; 26(2):382-393.
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Prolonged exposure to extracellular lumican restrains pancreatic adenocarcinoma growth. Oncogene. 2017 09 21; 36(38):5432-5438.
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Transforming Growth Factor-? Limits Secretion of Lumican by Activated Stellate Cells within Primary Pancreatic Adenocarcinoma Tumors. Clin Cancer Res. 2016 Oct 01; 22(19):4934-4946.
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Extracellular lumican augments cytotoxicity of chemotherapy in pancreatic ductal adenocarcinoma cells via autophagy inhibition. Oncogene. 2016 09 15; 35(37):4881-90.
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Extracellular lumican inhibits pancreatic cancer cell growth and is associated with prolonged survival after surgery. Clin Cancer Res. 2014 Dec 15; 20(24):6529-40.
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Multiplex targeted proteomic assay for biomarker detection in plasma: a pancreatic cancer biomarker case study. J Proteome Res. 2012 Mar 02; 11(3):1937-48.
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Proteomics portrait of archival lesions of chronic pancreatitis. PLoS One. 2011; 6(11):e27574.
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HMGA2 overexpression-induced ovarian surface epithelial transformation is mediated through regulation of EMT genes. Cancer Res. 2011 Jan 15; 71(2):349-59.