"Nogo Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Myelin proteins that are expressed as three isoforms: Nogo-A, Nogo-B, and Nogo-C. These share a C-terminal reticulon homology domain (RHD), consisting of two hydrophobic membrane domains flanking a 66 amino acid (Nogo-66) hydrophilic region. A long transmembrane region allows conformations that either span the entire membrane or fold into a hairpin conformation. Nogo inhibits NEURITE outgrowth and modulates wiring and the restriction of SYNAPTIC PLASTICITY in the adult central nervous system. It also regulates neurite fasciculation, branching, and extension in the developing nervous system.
| Descriptor ID |
D000070798
|
| MeSH Number(s) |
D12.776.543.620.738 D12.776.631.580.738
|
| Concept/Terms |
Nogo Proteins- Nogo Proteins
- Nogo Protein
- Reticulon-4 Protein
- Reticulon 4 Protein
Nogo-A Protein- Nogo-A Protein
- Nogo A Protein
- NI-250 Protein
- NI 250 Protein
- NI-220 Protein
- NI 220 Protein
Nogo-B Protein- Nogo-B Protein
- Nogo B Protein
- Reticulon 4-B Protein
- Reticulon 4 B Protein
|
Below are MeSH descriptors whose meaning is more general than "Nogo Proteins".
Below are MeSH descriptors whose meaning is more specific than "Nogo Proteins".
This graph shows the total number of publications written about "Nogo Proteins" by people in this website by year, and whether "Nogo Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 2 | 2 |
| 2004 | 0 | 3 | 3 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
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Below are the most recent publications written about "Nogo Proteins" by people in Profiles.
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Splicing factors PTBP1 and PTBP2 promote proliferation and migration of glioma cell lines. Brain. 2009 Aug; 132(Pt 8):2277-88.
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Mechanisms of CNS myelin inhibition: evidence for distinct and neuronal cell type specific receptor systems. Restor Neurol Neurosci. 2008; 26(2-3):97-115.
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Response to correspondence: Kim et al., "axon regeneration in young adult mice lacking Nogo-A/B." Neuron 38, 187-199. Neuron. 2007 Apr 19; 54(2):195-9.
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Alzheimer precursor protein interaction with the Nogo-66 receptor reduces amyloid-beta plaque deposition. J Neurosci. 2006 Feb 01; 26(5):1386-95.
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Nogo-66 receptor prevents raphespinal and rubrospinal axon regeneration and limits functional recovery from spinal cord injury. Neuron. 2004 Oct 28; 44(3):439-51.
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Nogo receptor antagonism promotes stroke recovery by enhancing axonal plasticity. J Neurosci. 2004 Jul 07; 24(27):6209-17.
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A new role for Nogo as a regulator of vascular remodeling. Nat Med. 2004 Apr; 10(4):382-8.
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Nogo-C is sufficient to delay nerve regeneration. Mol Cell Neurosci. 2003 Jul; 23(3):451-9.
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Axon regeneration in young adult mice lacking Nogo-A/B. Neuron. 2003 Apr 24; 38(2):187-99.
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Nerve regeneration: regrowth stumped by shared receptor. Curr Biol. 2002 Oct 01; 12(19):R654-6.