TIMOTHY PALZKILL to Structure-Activity Relationship
This is a "connection" page, showing publications TIMOTHY PALZKILL has written about Structure-Activity Relationship.
Connection Strength
0.649
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A triple mutant in the O-loop of TEM-1 ?-lactamase changes the substrate profile via a large conformational change and an altered general base for catalysis. J Biol Chem. 2015 Apr 17; 290(16):10382-94.
Score: 0.108
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Structural and biochemical evidence that a TEM-1 beta-lactamase N170G active site mutant acts via substrate-assisted catalysis. J Biol Chem. 2009 Nov 27; 284(48):33703-12.
Score: 0.074
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A broad-spectrum peptide inhibitor of beta-lactamase identified using phage display and peptide arrays. Protein Eng. 2003 Nov; 16(11):853-60.
Score: 0.049
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An analysis of why highly similar enzymes evolve differently. Genetics. 2003 Feb; 163(2):457-66.
Score: 0.047
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Molecular analysis of beta-lactamase structure and function. Int J Med Microbiol. 2002 Jul; 292(2):127-37.
Score: 0.045
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DNA-encoded chemistry technology yields expedient access to SARS-CoV-2 Mpro inhibitors. Proc Natl Acad Sci U S A. 2021 09 07; 118(36).
Score: 0.043
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Selection and characterization of amino acid substitutions at residues 237-240 of TEM-1 beta-lactamase with altered substrate specificity for aztreonam and ceftazidime. J Biol Chem. 1996 Sep 13; 271(37):22538-45.
Score: 0.030
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Amino acid sequence determinants of beta-lactamase structure and activity. J Mol Biol. 1996 May 17; 258(4):688-703.
Score: 0.029
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Systematic mutagenesis of the active site omega loop of TEM-1 beta-lactamase. J Bacteriol. 1996 Apr; 178(7):1821-8.
Score: 0.029
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Effect of threonine-to-methionine substitution at position 265 on structure and function of TEM-1 beta-lactamase. Antimicrob Agents Chemother. 1994 Oct; 38(10):2266-9.
Score: 0.026
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Characterization of TEM-1 beta-lactamase mutants from positions 238 to 241 with increased catalytic efficiency for ceftazidime. J Biol Chem. 1994 Sep 23; 269(38):23444-50.
Score: 0.026
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Evolution of antibiotic resistance: several different amino acid substitutions in an active site loop alter the substrate profile of beta-lactamase. Mol Microbiol. 1994 Apr; 12(2):217-29.
Score: 0.025
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Selection of functional signal peptide cleavage sites from a library of random sequences. J Bacteriol. 1994 Feb; 176(3):563-8.
Score: 0.025
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Probing beta-lactamase structure and function using random replacement mutagenesis. Proteins. 1992 Sep; 14(1):29-44.
Score: 0.023
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2-Substituted 4,5-dihydrothiazole-4-carboxylic acids are novel inhibitors of metallo-?-lactamases. Bioorg Med Chem Lett. 2012 Oct 01; 22(19):6229-32.
Score: 0.023
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Chromophoric spin-labeled beta-lactam antibiotics for ENDOR structural characterization of reaction intermediates of class A and class C beta-lactamases. Spectrochim Acta A Mol Biomol Spectrosc. 2004 May; 60(6):1279-89.
Score: 0.013
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Structure-function analysis of alpha-helix H4 using PSE-4 as a model enzyme representative of class A beta-lactamases. Protein Eng. 2000 Apr; 13(4):267-74.
Score: 0.010
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Roles of amino acids 161 to 179 in the PSE-4 omega loop in substrate specificity and in resistance to ceftazidime. Antimicrob Agents Chemother. 1998 Oct; 42(10):2576-83.
Score: 0.009
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Characterization of a PSE-4 mutant with different properties in relation to penicillanic acid sulfones: importance of residues 216 to 218 in class A beta-lactamases. Antimicrob Agents Chemother. 1998 Sep; 42(9):2319-25.
Score: 0.009
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Systematic mutagenesis of the yeast mating pheromone receptor third intracellular loop. J Biol Chem. 1994 Mar 25; 269(12):8831-41.
Score: 0.006