TIMOTHY PALZKILL to Protein Conformation
This is a "connection" page, showing publications TIMOTHY PALZKILL has written about Protein Conformation.
Connection Strength
1.072
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Local interactions with the Glu166 base and the conformation of an active site loop play key roles in carbapenem hydrolysis by the KPC-2 ?-lactamase. J Biol Chem. 2021 Jan-Jun; 296:100799.
Score: 0.159
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A drug-resistant ?-lactamase variant changes the conformation of its active-site proton shuttle to alter substrate specificity and inhibitor potency. J Biol Chem. 2020 12 25; 295(52):18239-18255.
Score: 0.153
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Synergistic effects of functionally distinct substitutions in ?-lactamase variants shed light on the evolution of bacterial drug resistance. J Biol Chem. 2018 11 16; 293(46):17971-17984.
Score: 0.133
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The Drug-Resistant Variant P167S Expands the Substrate Profile of CTX-M ?-Lactamases for Oxyimino-Cephalosporin Antibiotics by Enlarging the Active Site upon Acylation. Biochemistry. 2017 07 11; 56(27):3443-3453.
Score: 0.122
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How structural and physicochemical determinants shape sequence constraints in a functional enzyme. PLoS One. 2015; 10(2):e0118684.
Score: 0.104
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Role of ?-lactamase residues in a common interface for binding the structurally unrelated inhibitory proteins BLIP and BLIP-II. Protein Sci. 2014 Sep; 23(9):1235-46.
Score: 0.099
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Determination of the amino acid sequence requirements for catalysis by the highly proficient orotidine monophosphate decarboxylase. Protein Sci. 2011 Nov; 20(11):1891-906.
Score: 0.082
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Determinants of binding affinity and specificity for the interaction of TEM-1 and SME-1 beta-lactamase with beta-lactamase inhibitory protein. J Biol Chem. 2003 Nov 14; 278(46):45706-12.
Score: 0.047
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Identification of residues in beta-lactamase critical for binding beta-lactamase inhibitory protein. J Biol Chem. 1999 Mar 12; 274(11):6963-71.
Score: 0.034
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Amino acid sequence determinants of beta-lactamase structure and activity. J Mol Biol. 1996 May 17; 258(4):688-703.
Score: 0.028
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Structural Basis for Different Substrate Profiles of Two Closely Related Class D ?-Lactamases and Their Inhibition by Halogens. Biochemistry. 2015 Jun 02; 54(21):3370-80.
Score: 0.026
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Structural basis of substrate specificity and protease inhibition in Norwalk virus. J Virol. 2013 Apr; 87(8):4281-92.
Score: 0.022
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Probing beta-lactamase structure and function using random replacement mutagenesis. Proteins. 1992 Sep; 14(1):29-44.
Score: 0.022
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Identification of amino acid substitutions that alter the substrate specificity of TEM-1 beta-lactamase. J Bacteriol. 1992 Aug; 174(16):5237-43.
Score: 0.022
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Chromophoric spin-labeled beta-lactam antibiotics for ENDOR structural characterization of reaction intermediates of class A and class C beta-lactamases. Spectrochim Acta A Mol Biomol Spectrosc. 2004 May; 60(6):1279-89.
Score: 0.012
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The rate-limiting step in the folding of the cis-Pro167Thr mutant of TEM-1 beta-lactamase is the trans to cis isomerization of a non-proline peptide bond. Proteins. 1996 May; 25(1):104-11.
Score: 0.007