TIMOTHY PALZKILL to Hydrolysis
This is a "connection" page, showing publications TIMOTHY PALZKILL has written about Hydrolysis.
Connection Strength
2.195
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The mechanism of ceftazidime and cefiderocol hydrolysis by D179Y variants of KPC carbapenemases is similar and involves the formation of a long-lived covalent intermediate. Antimicrob Agents Chemother. 2024 03 06; 68(3):e0110823.
Score: 0.215
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An active site loop toggles between conformations to control antibiotic hydrolysis and inhibition potency for CTX-M ?-lactamase drug-resistance enzymes. Nat Commun. 2022 11 07; 13(1):6726.
Score: 0.198
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Evaluation of Tebipenem Hydrolysis by ?-Lactamases Prevalent in Complicated Urinary Tract Infections. Antimicrob Agents Chemother. 2022 05 17; 66(5):e0239621.
Score: 0.191
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Local interactions with the Glu166 base and the conformation of an active site loop play key roles in carbapenem hydrolysis by the KPC-2 ?-lactamase. J Biol Chem. 2021 Jan-Jun; 296:100799.
Score: 0.178
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Mechanistic Basis of OXA-48-like ?-Lactamases' Hydrolysis of Carbapenems. ACS Infect Dis. 2021 02 12; 7(2):445-460.
Score: 0.175
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Synergistic effects of functionally distinct substitutions in ?-lactamase variants shed light on the evolution of bacterial drug resistance. J Biol Chem. 2018 11 16; 293(46):17971-17984.
Score: 0.149
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The Drug-Resistant Variant P167S Expands the Substrate Profile of CTX-M ?-Lactamases for Oxyimino-Cephalosporin Antibiotics by Enlarging the Active Site upon Acylation. Biochemistry. 2017 07 11; 56(27):3443-3453.
Score: 0.136
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Deep Sequencing of Random Mutant Libraries Reveals the Active Site of the Narrow Specificity CphA Metallo-?-Lactamase is Fragile to Mutations. Sci Rep. 2016 09 12; 6:33195.
Score: 0.129
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Removal of the Side Chain at the Active-Site Serine by a Glycine Substitution Increases the Stability of a Wide Range of Serine ?-Lactamases by Relieving Steric Strain. Biochemistry. 2016 05 03; 55(17):2479-90.
Score: 0.126
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Natural Variants of the KPC-2 Carbapenemase have Evolved Increased Catalytic Efficiency for Ceftazidime Hydrolysis at the Cost of Enzyme Stability. PLoS Pathog. 2015 Jun; 11(6):e1004949.
Score: 0.118
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Deep sequencing of systematic combinatorial libraries reveals ?-lactamase sequence constraints at high resolution. J Mol Biol. 2012 Dec 07; 424(3-4):150-67.
Score: 0.098
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Genetic and structural characterization of an L201P global suppressor substitution in TEM-1 beta-lactamase. J Mol Biol. 2008 Dec 05; 384(1):151-64.
Score: 0.074
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Evaluation of penicillin-based inhibitors of the class A and B beta-lactamases from Bacillus anthracis. Biochem Biophys Res Commun. 2004 Jan 16; 313(3):541-5.
Score: 0.054
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Determinants of binding affinity and specificity for the interaction of TEM-1 and SME-1 beta-lactamase with beta-lactamase inhibitory protein. J Biol Chem. 2003 Nov 14; 278(46):45706-12.
Score: 0.052
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Amino acid sequence requirements at residues 69 and 238 for the SME-1 beta-lactamase to confer resistance to beta-lactam antibiotics. Antimicrob Agents Chemother. 2003 Mar; 47(3):1062-7.
Score: 0.050
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Identification of residues critical for metallo-beta-lactamase function by codon randomization and selection. Protein Sci. 2001 Dec; 10(12):2556-65.
Score: 0.046
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Amino acid sequence determinants of extended spectrum cephalosporin hydrolysis by the class C P99 beta-lactamase. J Biol Chem. 2001 Dec 07; 276(49):46568-74.
Score: 0.046
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The role of residue 238 of TEM-1 beta-lactamase in the hydrolysis of extended-spectrum antibiotics. J Biol Chem. 1998 Oct 09; 273(41):26603-9.
Score: 0.037
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Selection and characterization of amino acid substitutions at residues 237-240 of TEM-1 beta-lactamase with altered substrate specificity for aztreonam and ceftazidime. J Biol Chem. 1996 Sep 13; 271(37):22538-45.
Score: 0.032
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Molecular basis for the catalytic specificity of the CTX-M extended-spectrum ?-lactamases. Biochemistry. 2015 Jan 20; 54(2):447-57.
Score: 0.029
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Crystallographic Analysis of Rotavirus NSP2-RNA Complex Reveals Specific Recognition of 5' GG Sequence for RTPase Activity. J Virol. 2012 Oct; 86(19):10547-57.
Score: 0.024
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The D-methyl group in beta-lactamase evolution: evidence from the Y221G and GC1 mutants of the class C beta-lactamase of Enterobacter cloacae P99. Biochemistry. 2005 May 24; 44(20):7543-52.
Score: 0.015
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Chromophoric spin-labeled beta-lactam antibiotics for ENDOR structural characterization of reaction intermediates of class A and class C beta-lactamases. Spectrochim Acta A Mol Biomol Spectrosc. 2004 May; 60(6):1279-89.
Score: 0.014
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A secondary drug resistance mutation of TEM-1 beta-lactamase that suppresses misfolding and aggregation. Proc Natl Acad Sci U S A. 2001 Jan 02; 98(1):283-8.
Score: 0.011