TIMOTHY PALZKILL to Substrate Specificity
This is a "connection" page, showing publications TIMOTHY PALZKILL has written about Substrate Specificity.
Connection Strength
1.765
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Mapping the determinants of catalysis and substrate specificity of the antibiotic resistance enzyme CTX-M ?-lactamase. Commun Biol. 2023 01 12; 6(1):35.
Score: 0.199
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KPC-2 ?-lactamase enables carbapenem antibiotic resistance through fast deacylation of the covalent intermediate. J Biol Chem. 2021 Jan-Jun; 296:100155.
Score: 0.172
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A drug-resistant ?-lactamase variant changes the conformation of its active-site proton shuttle to alter substrate specificity and inhibitor potency. J Biol Chem. 2020 12 25; 295(52):18239-18255.
Score: 0.170
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The Drug-Resistant Variant P167S Expands the Substrate Profile of CTX-M ?-Lactamases for Oxyimino-Cephalosporin Antibiotics by Enlarging the Active Site upon Acylation. Biochemistry. 2017 07 11; 56(27):3443-3453.
Score: 0.135
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BLIP-II Employs Differential Hotspot Residues To Bind Structurally Similar Staphylococcus aureus PBP2a and Class A ?-Lactamases. Biochemistry. 2017 02 28; 56(8):1075-1084.
Score: 0.132
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Deep sequencing of phage-displayed peptide libraries reveals sequence motif that detects norovirus. Protein Eng Des Sel. 2017 Feb; 30(2):129-139.
Score: 0.131
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Deep Sequencing of Random Mutant Libraries Reveals the Active Site of the Narrow Specificity CphA Metallo-?-Lactamase is Fragile to Mutations. Sci Rep. 2016 09 12; 6:33195.
Score: 0.128
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A triple mutant in the O-loop of TEM-1 ?-lactamase changes the substrate profile via a large conformational change and an altered general base for catalysis. J Biol Chem. 2015 Apr 17; 290(16):10382-94.
Score: 0.115
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Metallo-?-lactamase structure and function. Ann N Y Acad Sci. 2013 Jan; 1277:91-104.
Score: 0.098
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Structural and biochemical evidence that a TEM-1 beta-lactamase N170G active site mutant acts via substrate-assisted catalysis. J Biol Chem. 2009 Nov 27; 284(48):33703-12.
Score: 0.079
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Amino acid residues that contribute to substrate specificity of class A beta-lactamase SME-1. Antimicrob Agents Chemother. 2005 Aug; 49(8):3421-7.
Score: 0.059
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Analysis of the context dependent sequence requirements of active site residues in the metallo-beta-lactamase IMP-1. J Mol Biol. 2004 Nov 26; 344(3):653-63.
Score: 0.057
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Dissecting the protein-protein interface between beta-lactamase inhibitory protein and class A beta-lactamases. J Biol Chem. 2004 Oct 08; 279(41):42860-6.
Score: 0.055
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Cephalosporin substrate specificity determinants of TEM-1 beta-lactamase. J Biol Chem. 1997 Nov 14; 272(46):29144-50.
Score: 0.035
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Selection and characterization of amino acid substitutions at residues 237-240 of TEM-1 beta-lactamase with altered substrate specificity for aztreonam and ceftazidime. J Biol Chem. 1996 Sep 13; 271(37):22538-45.
Score: 0.032
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Systematic mutagenesis of the active site omega loop of TEM-1 beta-lactamase. J Bacteriol. 1996 Apr; 178(7):1821-8.
Score: 0.031
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Characterization of TEM-1 beta-lactamase mutants from positions 238 to 241 with increased catalytic efficiency for ceftazidime. J Biol Chem. 1994 Sep 23; 269(38):23444-50.
Score: 0.028
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Evolution of antibiotic resistance: several different amino acid substitutions in an active site loop alter the substrate profile of beta-lactamase. Mol Microbiol. 1994 Apr; 12(2):217-29.
Score: 0.027
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Structural basis of substrate specificity and protease inhibition in Norwalk virus. J Virol. 2013 Apr; 87(8):4281-92.
Score: 0.025
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Identification of amino acid substitutions that alter the substrate specificity of TEM-1 beta-lactamase. J Bacteriol. 1992 Aug; 174(16):5237-43.
Score: 0.024
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Chromophoric spin-labeled beta-lactam antibiotics for ENDOR structural characterization of reaction intermediates of class A and class C beta-lactamases. Spectrochim Acta A Mol Biomol Spectrosc. 2004 May; 60(6):1279-89.
Score: 0.014
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A secondary drug resistance mutation of TEM-1 beta-lactamase that suppresses misfolding and aggregation. Proc Natl Acad Sci U S A. 2001 Jan 02; 98(1):283-8.
Score: 0.011
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Roles of amino acids 161 to 179 in the PSE-4 omega loop in substrate specificity and in resistance to ceftazidime. Antimicrob Agents Chemother. 1998 Oct; 42(10):2576-83.
Score: 0.009