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TIMOTHY PALZKILL to Mutagenesis, Site-Directed

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This is a "connection" page, showing publications TIMOTHY PALZKILL has written about Mutagenesis, Site-Directed.
TIMOTHY PALZKILL
Connection Strength
1.634
Mutagenesis, Site-Directed
  1. A drug-resistant ?-lactamase variant changes the conformation of its active-site proton shuttle to alter substrate specificity and inhibitor potency. J Biol Chem. 2020 12 25; 295(52):18239-18255.
    View in: PubMed
    Score: 0.170
  2. Synergistic effects of functionally distinct substitutions in ?-lactamase variants shed light on the evolution of bacterial drug resistance. J Biol Chem. 2018 11 16; 293(46):17971-17984.
    View in: PubMed
    Score: 0.147
  3. The Drug-Resistant Variant P167S Expands the Substrate Profile of CTX-M ?-Lactamases for Oxyimino-Cephalosporin Antibiotics by Enlarging the Active Site upon Acylation. Biochemistry. 2017 07 11; 56(27):3443-3453.
    View in: PubMed
    Score: 0.135
  4. Removal of the Side Chain at the Active-Site Serine by a Glycine Substitution Increases the Stability of a Wide Range of Serine ?-Lactamases by Relieving Steric Strain. Biochemistry. 2016 05 03; 55(17):2479-90.
    View in: PubMed
    Score: 0.125
  5. Natural Variants of the KPC-2 Carbapenemase have Evolved Increased Catalytic Efficiency for Ceftazidime Hydrolysis at the Cost of Enzyme Stability. PLoS Pathog. 2015 Jun; 11(6):e1004949.
    View in: PubMed
    Score: 0.117
  6. Identification of the ?-lactamase inhibitor protein-II (BLIP-II) interface residues essential for binding affinity and specificity for class A ?-lactamases. J Biol Chem. 2013 Jun 14; 288(24):17156-66.
    View in: PubMed
    Score: 0.101
  7. Determination of the amino acid sequence requirements for catalysis by the highly proficient orotidine monophosphate decarboxylase. Protein Sci. 2011 Nov; 20(11):1891-906.
    View in: PubMed
    Score: 0.091
  8. Analysis of the functional contributions of Asn233 in metallo-?-lactamase IMP-1. Antimicrob Agents Chemother. 2011 Dec; 55(12):5696-702.
    View in: PubMed
    Score: 0.090
  9. Structural and biochemical evidence that a TEM-1 beta-lactamase N170G active site mutant acts via substrate-assisted catalysis. J Biol Chem. 2009 Nov 27; 284(48):33703-12.
    View in: PubMed
    Score: 0.079
  10. Analysis of the plasticity of location of the Arg244 positive charge within the active site of the TEM-1 beta-lactamase. Protein Sci. 2009 Oct; 18(10):2080-9.
    View in: PubMed
    Score: 0.079
  11. Fine mapping of the sequence requirements for binding of beta-lactamase inhibitory protein (BLIP) to TEM-1 beta-lactamase using a genetic screen for BLIP function. J Mol Biol. 2009 Jun 05; 389(2):401-12.
    View in: PubMed
    Score: 0.077
  12. Amino acid residues that contribute to substrate specificity of class A beta-lactamase SME-1. Antimicrob Agents Chemother. 2005 Aug; 49(8):3421-7.
    View in: PubMed
    Score: 0.059
  13. Dissecting the protein-protein interface between beta-lactamase inhibitory protein and class A beta-lactamases. J Biol Chem. 2004 Oct 08; 279(41):42860-6.
    View in: PubMed
    Score: 0.055
  14. Amino acid sequence requirements at residues 69 and 238 for the SME-1 beta-lactamase to confer resistance to beta-lactam antibiotics. Antimicrob Agents Chemother. 2003 Mar; 47(3):1062-7.
    View in: PubMed
    Score: 0.050
  15. The role of residue 238 of TEM-1 beta-lactamase in the hydrolysis of extended-spectrum antibiotics. J Biol Chem. 1998 Oct 09; 273(41):26603-9.
    View in: PubMed
    Score: 0.037
  16. Cephalosporin substrate specificity determinants of TEM-1 beta-lactamase. J Biol Chem. 1997 Nov 14; 272(46):29144-50.
    View in: PubMed
    Score: 0.035
  17. A natural polymorphism in beta-lactamase is a global suppressor. Proc Natl Acad Sci U S A. 1997 Aug 05; 94(16):8801-6.
    View in: PubMed
    Score: 0.034
  18. Selection and characterization of amino acid substitutions at residues 237-240 of TEM-1 beta-lactamase with altered substrate specificity for aztreonam and ceftazidime. J Biol Chem. 1996 Sep 13; 271(37):22538-45.
    View in: PubMed
    Score: 0.032
  19. Systematic mutagenesis of the active site omega loop of TEM-1 beta-lactamase. J Bacteriol. 1996 Apr; 178(7):1821-8.
    View in: PubMed
    Score: 0.031
  20. Molecular basis for the catalytic specificity of the CTX-M extended-spectrum ?-lactamases. Biochemistry. 2015 Jan 20; 54(2):447-57.
    View in: PubMed
    Score: 0.028
  21. Effect of threonine-to-methionine substitution at position 265 on structure and function of TEM-1 beta-lactamase. Antimicrob Agents Chemother. 1994 Oct; 38(10):2266-9.
    View in: PubMed
    Score: 0.028
  22. Thermodynamic investigation of the role of contact residues of beta-lactamase-inhibitory protein for binding to TEM-1 beta-lactamase. J Biol Chem. 2007 Jun 15; 282(24):17676-84.
    View in: PubMed
    Score: 0.017
  23. Structure-function analysis of alpha-helix H4 using PSE-4 as a model enzyme representative of class A beta-lactamases. Protein Eng. 2000 Apr; 13(4):267-74.
    View in: PubMed
    Score: 0.010
  24. Systematic mutagenesis of the yeast mating pheromone receptor third intracellular loop. J Biol Chem. 1994 Mar 25; 269(12):8831-41.
    View in: PubMed
    Score: 0.007
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