TIMOTHY PALZKILL to Binding Sites
This is a "connection" page, showing publications TIMOTHY PALZKILL has written about Binding Sites.
Connection Strength
0.913
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KPC-2 ?-lactamase enables carbapenem antibiotic resistance through fast deacylation of the covalent intermediate. J Biol Chem. 2021 Jan-Jun; 296:100155.
Score: 0.140
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Removal of the Side Chain at the Active-Site Serine by a Glycine Substitution Increases the Stability of a Wide Range of Serine ?-Lactamases by Relieving Steric Strain. Biochemistry. 2016 05 03; 55(17):2479-90.
Score: 0.102
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A high-throughput percentage-of-binding strategy to measure binding energies in DNA-protein interactions: application to genome-scale site discovery. Nucleic Acids Res. 2008 Sep; 36(15):4863-71.
Score: 0.059
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Amino acid residues that contribute to substrate specificity of class A beta-lactamase SME-1. Antimicrob Agents Chemother. 2005 Aug; 49(8):3421-7.
Score: 0.048
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Functional analysis of active site residues of the fosfomycin resistance enzyme FosA from Pseudomonas aeruginosa. J Biol Chem. 2005 May 06; 280(18):17786-91.
Score: 0.047
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Analysis of the context dependent sequence requirements of active site residues in the metallo-beta-lactamase IMP-1. J Mol Biol. 2004 Nov 26; 344(3):653-63.
Score: 0.046
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A broad-spectrum peptide inhibitor of beta-lactamase identified using phage display and peptide arrays. Protein Eng. 2003 Nov; 16(11):853-60.
Score: 0.043
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Determinants of binding affinity and specificity for the interaction of TEM-1 and SME-1 beta-lactamase with beta-lactamase inhibitory protein. J Biol Chem. 2003 Nov 14; 278(46):45706-12.
Score: 0.042
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Identification of residues critical for metallo-beta-lactamase function by codon randomization and selection. Protein Sci. 2001 Dec; 10(12):2556-65.
Score: 0.038
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Amino acid sequence determinants of extended spectrum cephalosporin hydrolysis by the class C P99 beta-lactamase. J Biol Chem. 2001 Dec 07; 276(49):46568-74.
Score: 0.037
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Protein minimization by random fragmentation and selection. Protein Eng. 2001 Jul; 14(7):487-92.
Score: 0.036
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Design of potent beta-lactamase inhibitors by phage display of beta-lactamase inhibitory protein. J Biol Chem. 2000 May 19; 275(20):14964-8.
Score: 0.034
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Structural, Biochemical, and In Vivo Characterization of MtrR-Mediated Resistance to Innate Antimicrobials by the Human Pathogen Neisseria gonorrhoeae. J Bacteriol. 2019 10 15; 201(20).
Score: 0.032
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Cephalosporin substrate specificity determinants of TEM-1 beta-lactamase. J Biol Chem. 1997 Nov 14; 272(46):29144-50.
Score: 0.028
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Systematic mutagenesis of the active site omega loop of TEM-1 beta-lactamase. J Bacteriol. 1996 Apr; 178(7):1821-8.
Score: 0.025
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PBP2a mutations causing high-level Ceftaroline resistance in clinical methicillin-resistant Staphylococcus aureus isolates. Antimicrob Agents Chemother. 2014 Nov; 58(11):6668-74.
Score: 0.023
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Evolution of antibiotic resistance: several different amino acid substitutions in an active site loop alter the substrate profile of beta-lactamase. Mol Microbiol. 1994 Apr; 12(2):217-29.
Score: 0.022
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Probing beta-lactamase structure and function using random replacement mutagenesis. Proteins. 1992 Sep; 14(1):29-44.
Score: 0.020
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Co-crystal structures of PKG I? (92-227) with cGMP and cAMP reveal the molecular details of cyclic-nucleotide binding. PLoS One. 2011 Apr 19; 6(4):e18413.
Score: 0.018
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Epitope mapping and use of epitope-specific antisera to characterize the VP5* binding site in rotavirus SA11 NSP4. Virology. 2008 Mar 30; 373(1):211-28.
Score: 0.014
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Thermodynamic investigation of the role of contact residues of beta-lactamase-inhibitory protein for binding to TEM-1 beta-lactamase. J Biol Chem. 2007 Jun 15; 282(24):17676-84.
Score: 0.014
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Using peptide arrays to define nuclear carrier binding sites on nucleoporins. Methods. 2006 Aug; 39(4):329-41.
Score: 0.013
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The D-methyl group in beta-lactamase evolution: evidence from the Y221G and GC1 mutants of the class C beta-lactamase of Enterobacter cloacae P99. Biochemistry. 2005 May 24; 44(20):7543-52.
Score: 0.012
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Chromophoric spin-labeled beta-lactam antibiotics for ENDOR structural characterization of reaction intermediates of class A and class C beta-lactamases. Spectrochim Acta A Mol Biomol Spectrosc. 2004 May; 60(6):1279-89.
Score: 0.011
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Characterization of a PSE-4 mutant with different properties in relation to penicillanic acid sulfones: importance of residues 216 to 218 in class A beta-lactamases. Antimicrob Agents Chemother. 1998 Sep; 42(9):2319-25.
Score: 0.007