Lysergic Acid Diethylamide
"Lysergic Acid Diethylamide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is a potent hallucinogen, but the mechanisms of that effect are not well understood.
| Descriptor ID |
D008238
|
| MeSH Number(s) |
D03.132.327.287.572.522 D03.633.400.439.572.522
|
| Concept/Terms |
Lysergic Acid Diethylamide- Lysergic Acid Diethylamide
- Acid Diethylamide, Lysergic
- Diethylamide, Lysergic Acid
- Lysergide
- LSD
- LSD-25
- LSD 25
|
Below are MeSH descriptors whose meaning is more general than "Lysergic Acid Diethylamide".
Below are MeSH descriptors whose meaning is more specific than "Lysergic Acid Diethylamide".
This graph shows the total number of publications written about "Lysergic Acid Diethylamide" by people in this website by year, and whether "Lysergic Acid Diethylamide" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
| 2021 | 1 | 0 | 1 |
| 2022 | 1 | 0 | 1 |
| 2024 | 0 | 1 | 1 |
| 2025 | 0 | 1 | 1 |
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Below are the most recent publications written about "Lysergic Acid Diethylamide" by people in Profiles.
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Unequal representation? A cross-sectional analysis of age, sex, race, and ethnicity in clinical trials of classic psychedelics. J Psychopharmacol. 2025 Sep; 39(9):1014-1022.
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Efficacy and safety of psychedelics for the treatment of mental disorders: A systematic review and meta-analysis. Psychiatry Res. 2024 May; 335:115886.
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Psychedelic Therapy: A Primer for Primary Care Clinicians-Lysergic Acid Diethylamide (LSD). Am J Ther. 2024 Mar-Apr 01; 31(2):e104-e111.
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Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD. Neuron. 2022 Oct 05; 110(19):3154-3167.e7.
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LSD degrades hippocampal spatial representations and suppresses hippocampal-visual cortical interactions. Cell Rep. 2021 09 14; 36(11):109714.
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Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor. Cell. 2020 09 17; 182(6):1574-1588.e19.
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Prevalence and risk factors for LSD use among young women. J Pediatr Adolesc Gynecol. 2003 Apr; 16(2):67-75.
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Serotonergic and adrenergic regulation of skeletal muscle metabolism in the rat. II. The use of [125I]iodolysergic acid diethylamide and [125I]iodopindolol as probes of sarcolemmal receptor function and specificity. J Biol Chem. 1983 Oct 25; 258(20):12499-508.
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The metabolism of lysergic acid DI[14C]ethylamide ([14C]LSD) in the isolated perfused rat liver. Biochem Pharmacol. 1979 Oct 15; 28(20):3081-91.
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The fate of lysergic acid DI[14C]ethylamide ([14C]LSD) in the rat, guinea pig and rhesus monkey and of [14C]iso-LSD in rat. Biochem Pharmacol. 1979 Oct 15; 28(20):3093-101.