Neural Cell Adhesion Molecule L1
"Neural Cell Adhesion Molecule L1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A member of the immunoglobulin superfamily of neuronal cell adhesion molecules that is required for proper nervous system development. Neural cell adhesion molecule L1 consists of six Ig domains, five fibronectin domains, a transmembrane region and an intracellular domain. Two splicing variants are known: a neuronal form that contains a four-amino acid RSLE sequence in the cytoplasmic domain, and a non-neuronal form that lacks the RSLE sequence. Mutations in the L1 gene result in L1 disease. Neural cell adhesion molecule L1 is predominantly expressed during development in neurons and Schwann cells; involved in cell adhesion, neuronal migration, axonal growth and pathfinding, and myelination.
Descriptor ID |
D039842
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MeSH Number(s) |
D12.776.395.550.200.250.520.578 D12.776.543.550.200.250.520.578 D23.050.301.350.250.520.578
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Concept/Terms |
Neural Cell Adhesion Molecule L1- Neural Cell Adhesion Molecule L1
- NILE Glycoprotein
- Glycoprotein, NILE
- Nerve Growth Factor-Inducible Large External Glycoprotein
- Nerve Growth Factor Inducible Large External Glycoprotein
- CALL Protein
- CamL1 Gene Product
- Neural Adhesion Molecule L1
- L1 Cell Adhesion Molecule
- L1CAM
- NILE Protein
- Cell Adhesion Molecule L1
- Cell Surface Glycoprotein L1
- NGF-Inducible Glycoprotein
- Glycoprotein, NGF-Inducible
- NGF Inducible Glycoprotein
- F11 Glycoprotein
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This graph shows the total number of publications written about "Neural Cell Adhesion Molecule L1" by people in this website by year, and whether "Neural Cell Adhesion Molecule L1" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2002 | 0 | 1 | 1 |
2014 | 0 | 2 | 2 |
2018 | 0 | 1 | 1 |
2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Neural Cell Adhesion Molecule L1" by people in Profiles.
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Androgen drives melanoma invasiveness and metastatic spread by inducing tumorigenic fucosylation. Nat Commun. 2024 Feb 07; 15(1):1148.
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L1CAM is required for early dissemination of fallopian tube carcinoma precursors to the ovary. Commun Biol. 2022 12 12; 5(1):1362.
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L1CAM and laminin vascular network: Association with the high-risk replacement histopathologic growth pattern in uveal melanoma liver metastases. Lab Invest. 2022 11; 102(11):1214-1224.
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Cerebrospinal fluid NCAM-1 concentration is associated with neurodevelopmental outcome in post-hemorrhagic hydrocephalus of prematurity. PLoS One. 2021; 16(3):e0247749.
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Clinical Reasoning: Ventriculomegaly detected on 20-week anatomic fetal ultrasound. Neurology. 2018 09 25; 91(13):e1265-e1268.
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Pericyte-like spreading by disseminated cancer cells activates YAP and MRTF for metastatic colonization. Nat Cell Biol. 2018 08; 20(8):966-978.
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TWIST1 drives cisplatin resistance and cell survival in an ovarian cancer model, via upregulation of GAS6, L1CAM, and Akt signalling. Sci Rep. 2016 11 23; 6:37652.
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A genetic association study of activated partial thromboplastin time in European Americans and African Americans: the ARIC Study. Hum Mol Genet. 2015 Apr 15; 24(8):2401-8.
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C11orf95-RELA fusion present in a primary supratentorial ependymoma and recurrent sarcoma. Brain Tumor Pathol. 2015 Apr; 32(2):105-11.
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Serpins promote cancer cell survival and vascular co-option in brain metastasis. Cell. 2014 Feb 27; 156(5):1002-16.