"Leukocyte Elastase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the hydrolysis of proteins, including elastin. It cleaves preferentially bonds at the carboxyl side of Ala and Val, with greater specificity for Ala. EC 3.4.21.37.
| Descriptor ID |
D019272
|
| MeSH Number(s) |
D08.811.277.656.300.760.560.500 D08.811.277.656.959.350.560.500
|
| Concept/Terms |
Leukocyte Elastase- Leukocyte Elastase
- Elastase, Leukocyte
- Polymorphonuclear Leukocyte Elastase
- Elastase, Polymorphonuclear Leukocyte
- Leukocyte Elastase, Polymorphonuclear
- Neutrophil Elastase
- Elastase, Neutrophil
- PMN Elastase
- Elastase, PMN
- Granulocyte Elastase
- Elastase, Granulocyte
- Lysosomal Elastase
- Elastase, Lysosomal
|
Below are MeSH descriptors whose meaning is more general than "Leukocyte Elastase".
Below are MeSH descriptors whose meaning is more specific than "Leukocyte Elastase".
This graph shows the total number of publications written about "Leukocyte Elastase" by people in this website by year, and whether "Leukocyte Elastase" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 1997 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2008 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 1 | 2 |
| 2018 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
| 2025 | 0 | 1 | 1 |
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Below are the most recent publications written about "Leukocyte Elastase" by people in Profiles.
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CRISPR-Cas9 mediated proteinase 3 autoantigen deletion as a treatment strategy for anti-neutrophil cytoplasmic autoantibody-associated vasculitis. Kidney Int. 2025 Jul; 108(1):145-149.
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Endogenous Retroviral Elements Generate Pathologic Neutrophils in Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2022 10 15; 206(8):1019-1034.
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Elastin-Specific Autoimmunity in Smokers With Thoracic Aortic Aneurysm and Dissection is Independent of Chronic Obstructive Pulmonary Disease. J Am Heart Assoc. 2019 04 16; 8(8):e011671.
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SAG/RBX2 E3 Ubiquitin Ligase Differentially Regulates Inflammatory Responses of Myeloid Cell Subsets. Front Immunol. 2018; 9:2882.
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Activation of C3a receptor is required in cigarette smoke-mediated emphysema. Mucosal Immunol. 2015 Jul; 8(4):874-85.
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Neutrophil Elastase in the capacity of the "H2A-specific protease". Int J Biochem Cell Biol. 2014 Jun; 51:39-44.
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Generation of multi-leukemia antigen-specific T cells to enhance the graft-versus-leukemia effect after allogeneic stem cell transplant. Leukemia. 2013 Jul; 27(7):1538-47.
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Broad cross-presentation of the hematopoietically derived PR1 antigen on solid tumors leads to susceptibility to PR1-targeted immunotherapy. J Immunol. 2012 Dec 01; 189(11):5476-84.
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Breast cancer cell uptake of the inflammatory mediator neutrophil elastase triggers an anticancer adaptive immune response. Cancer Res. 2012 Jul 01; 72(13):3153-62.
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The role of antigen cross-presentation from leukemia blasts on immunity to the leukemia-associated antigen PR1. J Immunother. 2012 May; 35(4):309-20.