"Giant Cell Tumor of Bone" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A bone tumor composed of cellular spindle-cell stroma containing scattered multinucleated giant cells resembling osteoclasts. The tumors range from benign to frankly malignant lesions. The tumor occurs most frequently in an end of a long tubular bone in young adults. (From Dorland, 27th ed; Stedman, 25th ed)
| Descriptor ID |
D018212
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| MeSH Number(s) |
C04.557.450.565.380.380 C04.557.450.565.575.420
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Giant Cell Tumor of Bone".
Below are MeSH descriptors whose meaning is more specific than "Giant Cell Tumor of Bone".
This graph shows the total number of publications written about "Giant Cell Tumor of Bone" by people in this website by year, and whether "Giant Cell Tumor of Bone" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 2 | 0 | 2 |
| 2001 | 0 | 1 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Giant Cell Tumor of Bone" by people in Profiles.
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Response to Denosumab in 2 Children With Recurrent Giant Cell Tumor of the Bone With Pulmonary Metastasis. J Pediatr Hematol Oncol. 2021 03 01; 43(2):e215-e218.
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The role of the fibula head flap for joint reconstruction after osteoarticular resections. J Plast Reconstr Aesthet Surg. 2014 May; 67(5):617-23.
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Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone. Nat Genet. 2013 Dec; 45(12):1479-82.
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Image-guided multilevel vertebral osteotomies for en bloc resection of giant cell tumor of the thoracic spine: case report and description of operative technique. Eur Spine J. 2010 Jun; 19(6):1021-8.
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Giant cell tumor of bone with pulmonary metastases. Med Pediatr Oncol. 2003 Nov; 41(5):454-9.
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Upper limb salvage with microvascular bone transfer for major long-bone segmental tumor resections. Ann Plast Surg. 2001 Sep; 47(3):240-6.
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Interleukin-1beta upregulates MMP-9 expression in stromal cells of human giant cell tumor of bone. J Interferon Cytokine Res. 1999 Oct; 19(10):1207-17.
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Transcriptional regulation of MMP-9 expression in stromal cells of human giant cell tumor of bone by tumor necrosis factor-alpha. Int J Oncol. 1999 Feb; 14(2):291-300.
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Regulation of MMP-9 (92 kDa type IV collagenase/gelatinase B) expression in stromal cells of human giant cell tumor of bone. Clin Exp Metastasis. 1997 Jul; 15(4):400-9.
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Benign giant cell tumor of bone with osteosarcomatous transformation ("dedifferentiated" primary malignant GCT): report of two cases. Skeletal Radiol. 1997 Apr; 26(4):246-55.