Leukemia, Large Granular Lymphocytic
"Leukemia, Large Granular Lymphocytic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A spectrum of disorders characterized by clonal expansions of the peripheral blood LYMPHOCYTE populations known as large granular lymphocytes which contain abundant cytoplasm and azurophilic granules. Subtypes develop from either CD3-negative NATURAL KILLER CELLS or CD3-positive T-CELLS. The clinical course of both subtypes can vary from spontaneous regression to progressive, malignant disease.
| Descriptor ID |
D054066
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| MeSH Number(s) |
C04.557.337.428.580.049 C15.604.515.560.575.049 C20.683.515.528.582.049
|
| Concept/Terms |
Leukemia, Large Granular Lymphocytic- Leukemia, Large Granular Lymphocytic
- Aggressive NK Cell Leukemia
- Leukemia, Lymphocytic, Large Granular
- Large Granular Lymphocyte Leukemia
- LGL Leukemia
- LGL Leukemias
- Leukemias, LGL
- Lymphoproliferative Disease of Large Granular Lymphocytes
- Leukemia, LGL
- Aggressive Natural Killer Cell Leukemia
- Lymphoproliferative Disease of Granular Lymphocytes
Leukemia, T-Cell Large Granular Lymphocytic- Leukemia, T-Cell Large Granular Lymphocytic
- Leukemia, T Cell Large Granular Lymphocytic
- T-LGL Leukemia
- Leukemias, T-LGL
- T LGL Leukemia
- T-LGL Leukemias
- T-Cell Large Granular Lymphocyte Leukemia
- T Cell Large Granular Lymphocyte Leukemia
- T-Cell Large Granular Lymphocytic Leukemia
- T Cell Large Granular Lymphocytic Leukemia
- Leukemia, T-LGL
- Leukemia, T LGL
- Large Granular Lymphocytosis
- Granular Lymphocytoses, Large
- Granular Lymphocytosis, Large
- Large Granular Lymphocytoses
- Lymphocytoses, Large Granular
- Lymphocytosis, Large Granular
Leukemia, Natural Killer Cell Large Granular Lymphocytic- Leukemia, Natural Killer Cell Large Granular Lymphocytic
- Natural Killer Cell Large Granular Lymphocytic Leukemia
- Leukemia, NK-LGL
- Leukemia, NK LGL
- NK-Cell Large Granular Lymphocytic Leukemia
- NK Cell Large Granular Lymphocytic Leukemia
- NK-LGL Leukemia
- Leukemias, NK-LGL
- NK LGL Leukemia
- NK-LGL Leukemias
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Below are MeSH descriptors whose meaning is more general than "Leukemia, Large Granular Lymphocytic".
Below are MeSH descriptors whose meaning is more specific than "Leukemia, Large Granular Lymphocytic".
This graph shows the total number of publications written about "Leukemia, Large Granular Lymphocytic" by people in this website by year, and whether "Leukemia, Large Granular Lymphocytic" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 1 | 0 | 1 |
| 2009 | 2 | 0 | 2 |
| 2010 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 2 | 0 | 2 |
| 2016 | 1 | 0 | 1 |
| 2017 | 2 | 0 | 2 |
| 2018 | 4 | 1 | 5 |
| 2020 | 1 | 0 | 1 |
| 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Leukemia, Large Granular Lymphocytic" by people in Profiles.
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STAT3 gain-of-function mutations connect leukemia with autoimmune disease by pathological NKG2Dhi CD8+?T?cell dysregulation and accumulation. Immunity. 2022 12 13; 55(12):2386-2404.e8.
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Genomic and Immunophenotypic Landscape of Aggressive NK-Cell Leukemia. Am J Surg Pathol. 2020 09; 44(9):1235-1243.
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T-cell large granular lymphocytic leukaemia in the context of rheumatoid arthritis. Lancet. 2018 09 22; 392(10152):1071.
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Recent insights into large granular lymphocytic leukemia. Clin Adv Hematol Oncol. 2018 Jul; 16(7):469-471.
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Chronic lymphoproliferative disorder of NK-cells: A single-institution review with emphasis on relative utility of multimodality diagnostic tools. Eur J Haematol. 2018 May; 100(5):444-454.
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Pruritic arthropod bite-like papules in T-cell large granular lymphocytic leukaemia and chronic myelomonocytic leukaemia. Clin Exp Dermatol. 2018 Jun; 43(4):449-453.
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T-Cell Large Granular Lymphocytic Leukemia and Coexisting B-Cell Lymphomas: A Study From the Bone Marrow Pathology Group. Am J Clin Pathol. 2018 Jan 29; 149(2):164-171.
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EBV-negative Aggressive NK-cell Leukemia/Lymphoma: Clinical, Pathologic, and Genetic Features. Am J Surg Pathol. 2017 01; 41(1):67-74.
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Distinguishing Between Hepatosplenic T-cell Lymphoma and ?d T-cell Large Granular Lymphocytic Leukemia: A Clinicopathologic, Immunophenotypic, and Molecular Analysis. Am J Surg Pathol. 2017 01; 41(1):82-93.
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Donor-Derived T-Cell Large Granular Lymphocytic Leukemia in a Patient With Peripheral T-Cell Lymphoma. J Natl Compr Canc Netw. 2016 08; 14(8):939-44.