"Chlorpromazine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
| Descriptor ID |
D002746
|
| MeSH Number(s) |
D02.886.369.198 D03.633.300.741.198
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Chlorpromazine".
Below are MeSH descriptors whose meaning is more specific than "Chlorpromazine".
This graph shows the total number of publications written about "Chlorpromazine" by people in this website by year, and whether "Chlorpromazine" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 2 | 2 |
| 2001 | 2 | 0 | 2 |
| 2002 | 0 | 1 | 1 |
| 2008 | 1 | 1 | 2 |
| 2010 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Chlorpromazine" by people in Profiles.
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Differential effects of parental socioeconomic status on cortical thickness in patients with schizophrenia spectrum disorders and healthy controls. Neurosci Lett. 2023 05 01; 804:137239.
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Prone positioning without neuromuscular blockade during extracorporeal membrane oxygenation in children. Pediatr Int. 2020 05; 62(5):649-651.
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Chlorpromazine-induced hepatotoxicity during inflammation is mediated by TIRAP-dependent signaling pathway in mice. Toxicol Appl Pharmacol. 2013 Feb 01; 266(3):430-8.
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Role of c-Jun N-terminal kinase (JNK) in regulating tumor necrosis factor-alpha (TNF-alpha) mediated increase of acetaminophen (APAP) and chlorpromazine (CPZ) toxicity in murine hepatocytes. J Toxicol Sci. 2010 Apr; 35(2):163-73.
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Influence of chlorpromazine on eryptosis, parasitemia and survival of Plasmodium berghe infected mice. Cell Physiol Biochem. 2008; 22(1-4):261-8.
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Use of palliative sedation for intractable symptoms in the palliative care unit of a comprehensive cancer center. Support Care Cancer. 2009 Jan; 17(1):53-9.
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Excess plasma membrane and effects of ionic amphipaths on mechanics of outer hair cell lateral wall. Am J Physiol Cell Physiol. 2002 May; 282(5):C1076-86.
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What is your diagnosis? Hyperpigmentation due to long-term chlorpromazine use. Cutis. 2001 Oct; 68(4):252, 260.
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Chlorpromazine alters outer hair cell electromotility. Otolaryngol Head Neck Surg. 2001 Jul; 125(1):71-6.
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Sex differences in self-reported and physiological response to oral cocaine and placebo in humans. Am J Drug Alcohol Abuse. 2000 Nov; 26(4):643-57.