"Hemophilia B" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A deficiency of blood coagulation factor IX inherited as an X-linked disorder. (Also known as Christmas Disease, after the first patient studied in detail, not the holy day.) Historical and clinical features resemble those in classic hemophilia (HEMOPHILIA A), but patients present with fewer symptoms. Severity of bleeding is usually similar in members of a single family. Many patients are asymptomatic until the hemostatic system is stressed by surgery or trauma. Treatment is similar to that for hemophilia A. (From Cecil Textbook of Medicine, 19th ed, p1008)
| Descriptor ID |
D002836
|
| MeSH Number(s) |
C15.378.100.100.510 C15.378.100.141.510 C15.378.463.510 C16.320.099.510 C16.320.322.235
|
| Concept/Terms |
Hemophilia B- Hemophilia B
- Bs, Hemophilia
- Hemophilia Bs
- Deficiency, Factor IX
- Deficiencies, Factor IX
- Factor IX Deficiencies
- Factor IX Deficiency
- Hemophilia B Leyden
- Hemophilia B(M)
- Hemophilia Bs (M)
- Plasma Thromboplastin Component Deficiency
- F9 Deficiency
- Deficiencies, F9
- Deficiency, F9
- F9 Deficiencies
- Christmas Disease
- Disease, Christmas
- Haemophilia B
- Haemophilia Bs
|
Below are MeSH descriptors whose meaning is more general than "Hemophilia B".
Below are MeSH descriptors whose meaning is more specific than "Hemophilia B".
This graph shows the total number of publications written about "Hemophilia B" by people in this website by year, and whether "Hemophilia B" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 |
| 1995 | 1 | 0 | 1 |
| 2005 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
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Below are the most recent publications written about "Hemophilia B" by people in Profiles.
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Haemophilia B acquired from liver transplantation: a case report and literature review. Haemophilia. 2015 Jul; 21(4):e328-30.
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Balloon catheter delivery of helper-dependent adenoviral vector results in sustained, therapeutic hFIX expression in rhesus macaques. Mol Ther. 2012 Oct; 20(10):1863-70.
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Bioengineered factor IX molecules with increased catalytic activity improve the therapeutic index of gene therapy vectors for hemophilia B. Hum Gene Ther. 2009 May; 20(5):479-85.
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Sustained phenotypic correction of canine hemophilia B after systemic administration of helper-dependent adenoviral vector. Hum Gene Ther. 2005 Jul; 16(7):811-20.
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Gene therapy for hemophilia B: host immunosuppression prolongs the therapeutic effect of adenovirus-mediated factor IX expression. Hum Gene Ther. 1995 Aug; 6(8):1039-44.
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In vivo hepatic gene therapy: complete albeit transient correction of factor IX deficiency in hemophilia B dogs. Proc Natl Acad Sci U S A. 1994 Mar 15; 91(6):2353-7.
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In vivo gene therapy of hemophilia B: sustained partial correction in factor IX-deficient dogs. Science. 1993 Oct 01; 262(5130):117-9.
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A multicenter study of viral hepatitis in a United States hemophilic population. Blood. 1993 Jan 15; 81(2):412-8.
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Neuropsychologic functioning of human immunodeficiency virus-infected children with hemophilia. J Pediatr. 1993 Jan; 122(1):52-9.
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Defect in B cell function in HTLV III/LAV positive hemophilia patients. Blood. 1987 May; 69(5):1388-93.