"Angiostatins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Circulating 38-kDa proteins that are internal peptide fragments of PLASMINOGEN. The name derives from the fact that they are potent ANGIOGENESIS INHIBITORS. Angiostatins contain four KRINGLE DOMAINS which are associated with their potent angiostatic activity.
| Descriptor ID |
D043168
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| MeSH Number(s) |
D08.622.610.500 D12.644.276.100.450.500 D12.776.124.790.223.580.500 D12.776.377.715.182.580.500 D12.776.467.100.450.500 D23.529.100.450.500
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Angiostatins".
Below are MeSH descriptors whose meaning is more specific than "Angiostatins".
This graph shows the total number of publications written about "Angiostatins" by people in this website by year, and whether "Angiostatins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 2 | 2 |
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Below are the most recent publications written about "Angiostatins" by people in Profiles.
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Rapamycin-regulated control of antiangiogenic tumor therapy following rAAV-mediated gene transfer. Mol Ther. 2007 May; 15(5):912-20.
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Antiangiogenesis -- therapeutic strategies and clinical implications for brain tumors. J Neurooncol. 2000 Oct-Nov; 50(1-2):189-200.
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Urinary proteins with pro-apoptotic and antitumor activity. Apoptosis. 2000 Feb; 5(1):21-8.
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Transforming growth factor-beta 1 inhibits generation of angiostatin by human pancreatic cancer cells. Surgery. 1998 Aug; 124(2):388-93.
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Angiostatin generation by human pancreatic cancer. J Surg Res. 1998 Jun; 77(1):55-8.
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Angiostatin induces endothelial cell apoptosis and activation of focal adhesion kinase independently of the integrin-binding motif RGD. Proc Natl Acad Sci U S A. 1998 May 12; 95(10):5579-83.
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Suppression of tumor growth with recombinant murine angiostatin. Biochem Biophys Res Commun. 1997 Jul 30; 236(3):651-4.
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Kringle domains of human angiostatin. Characterization of the anti-proliferative activity on endothelial cells. J Biol Chem. 1996 Nov 15; 271(46):29461-7.