Polymerase Chain Reaction
"Polymerase Chain Reaction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Descriptor ID |
D016133
|
MeSH Number(s) |
E05.393.620.500
|
Concept/Terms |
Polymerase Chain Reaction- Polymerase Chain Reaction
- Polymerase Chain Reactions
- Reaction, Polymerase Chain
- Reactions, Polymerase Chain
- PCR
Inverse PCR- Inverse PCR
- PCR, Inverse
- Inverse Polymerase Chain Reaction
Anchored PCR- Anchored PCR
- PCR, Anchored
- Anchored Polymerase Chain Reaction
|
Below are MeSH descriptors whose meaning is more general than "Polymerase Chain Reaction".
Below are MeSH descriptors whose meaning is more specific than "Polymerase Chain Reaction".
This graph shows the total number of publications written about "Polymerase Chain Reaction" by people in this website by year, and whether "Polymerase Chain Reaction" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1994 | 10 | 83 | 93 |
1995 | 11 | 89 | 100 |
1996 | 21 | 91 | 112 |
1997 | 9 | 94 | 103 |
1998 | 9 | 90 | 99 |
1999 | 8 | 53 | 61 |
2000 | 8 | 74 | 82 |
2001 | 4 | 59 | 63 |
2002 | 7 | 64 | 71 |
2003 | 7 | 102 | 109 |
2004 | 5 | 85 | 90 |
2005 | 7 | 87 | 94 |
2006 | 4 | 80 | 84 |
2007 | 6 | 70 | 76 |
2008 | 7 | 81 | 88 |
2009 | 5 | 68 | 73 |
2010 | 5 | 101 | 106 |
2011 | 10 | 77 | 87 |
2012 | 4 | 48 | 52 |
2013 | 7 | 45 | 52 |
2014 | 4 | 33 | 37 |
2015 | 3 | 45 | 48 |
2016 | 6 | 36 | 42 |
2017 | 5 | 21 | 26 |
2018 | 2 | 15 | 17 |
2019 | 3 | 12 | 15 |
2020 | 2 | 9 | 11 |
2021 | 0 | 9 | 9 |
2022 | 0 | 1 | 1 |
2023 | 0 | 1 | 1 |
2024 | 0 | 2 | 2 |
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Below are the most recent publications written about "Polymerase Chain Reaction" by people in Profiles.
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Isolation of XO Subclones from XY Murine Embryonic Stem Cells. Cold Spring Harb Protoc. 2024 Jan 02; 2024(1):pdb.prot108038.
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Sex Genotyping Mice by Polymerase Chain Reaction. Cold Spring Harb Protoc. 2024 Jan 02; 2024(1):pdb.prot108062.
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Undetectable JC virus CSF PCR in patients with JC virus-induced progressive multifocal leukoencephalopathy. J Neurovirol. 2023 02; 29(1):94-99.
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Ensemble of nucleic acid absolute quantitation modules for copy number variation detection and RNA profiling. Nat Commun. 2022 04 04; 13(1):1791.
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Ultrasensitive detection of BRAF mutations in circulating tumor DNA of non-metastatic melanoma. ESMO Open. 2022 02; 7(1):100357.
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Comparison of Whole Genome Sequencing and Repetitive Element PCR for Multidrug-Resistant Pseudomonas aeruginosa Strain Typing. J Mol Diagn. 2022 02; 24(2):158-166.
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Cloning and over Expression Studies of Ovine Somatotropin cDNA of Kajli (sheep breed) in a Prokaryotic System. J Oleo Sci. 2021 Dec 03; 70(12):1791-1796.
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Persistence of G10P[11] neonatal rotavirus infections in southern India. J Clin Virol. 2021 11; 144:104989.
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Diagnostic Value of 16S Ribosomal RNA Gene Polymerase Chain Reaction/Sanger Sequencing in Clinical Practice. Clin Infect Dis. 2021 09 15; 73(6):961-968.
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Comprehensive Characterization of COVID-19 Patients with Repeatedly Positive SARS-CoV-2 Tests Using a Large U.S. Electronic Health Record Database. Microbiol Spectr. 2021 09 03; 9(1):e0032721.