"alpha-Globins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Members of the alpha-globin family. In humans, they are encoded in a gene cluster on CHROMOSOME 16. They include zeta-globin and alpha-globin. There are also pseudogenes of zeta (theta-zeta) and alpha (theta-alpha) in the cluster. Adult HEMOGLOBIN is comprised of 2 alpha-globin chains and 2 beta-globin chains.
| Descriptor ID |
D055542
|
| MeSH Number(s) |
D12.776.124.400.434.320 D12.776.422.316.762.403.320
|
| Concept/Terms |
alpha-1 Globin- alpha-1 Globin
- Globin, alpha-1
- alpha 1 Globin
- alpha 1-globin
- 1-globin, alpha
|
Below are MeSH descriptors whose meaning is more general than "alpha-Globins".
Below are MeSH descriptors whose meaning is more specific than "alpha-Globins".
This graph shows the total number of publications written about "alpha-Globins" by people in this website by year, and whether "alpha-Globins" was a major or minor topic of these publications.
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Below are the most recent publications written about "alpha-Globins" by people in Profiles.
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Comparisons of oxygen gradient ektacytometry parameters between sickle cell patients with or without a-thalassaemia. Br J Haematol. 2021 11; 195(4):629-633.
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Gene replacement of a-globin with ?-globin restores hemoglobin balance in ?-thalassemia-derived hematopoietic stem and progenitor cells. Nat Med. 2021 04; 27(4):677-687.
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Role of Heme Pocket Water in Allosteric Regulation of Ligand Reactivity in Human Hemoglobin. Biochemistry. 2016 07 26; 55(29):4005-17.
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Kinetics of a-globin binding to a-hemoglobin stabilizing protein (AHSP) indicate preferential stabilization of hemichrome folding intermediate. J Biol Chem. 2012 Mar 30; 287(14):11338-50.
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Coexpression of human alpha- and circularly permuted beta-globins yields a hemoglobin with normal R state but modified T state properties. Biochemistry. 2009 Jun 16; 48(23):5456-65.
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Analysis of human alpha globin gene mutations that impair binding to the alpha hemoglobin stabilizing protein. Blood. 2009 Jun 04; 113(23):5961-9.