Macrophage-Activating Factors
"Macrophage-Activating Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Factors secreted by stimulated lymphocytes that prime macrophages to become nonspecifically cytotoxic to tumors. They also modulate the expression of macrophage cell surface Ia antigens. One MAF is INTERFERON-GAMMA. Other factors antigenically distinct from IFN-gamma have also been identified.
| Descriptor ID |
D016215
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| MeSH Number(s) |
D12.644.276.374.480.615 D12.776.467.374.480.615 D23.529.374.480.615
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Macrophage-Activating Factors".
Below are MeSH descriptors whose meaning is more specific than "Macrophage-Activating Factors".
This graph shows the total number of publications written about "Macrophage-Activating Factors" by people in this website by year, and whether "Macrophage-Activating Factors" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
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Below are the most recent publications written about "Macrophage-Activating Factors" by people in Profiles.
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ImmTher, a lipophilic disaccharide derivative of muramyl dipeptide, up-regulates specific monocyte cytokine genes and activates monocyte-mediated tumoricidal activity. Cancer Immunol Immunother. 1999 Sep; 48(6):312-20.
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Activation of monocyte-mediated tumoricidal activity in patients with acquired immunodeficiency syndrome. J Clin Oncol. 1985 Jul; 3(7):1005-12.
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Lysis of tumor cells by human blood monocytes by a mechanism independent of activation of the oxidative burst. Cancer Res. 1985 May; 45(5):2058-64.
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Intracellular activation of human and rodent macrophages by human lymphokines encapsulated in liposomes. J Leukoc Biol. 1985 May; 37(5):571-84.
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Human monocyte-mediated cytotoxicity against herpes simplex virus-infected cells: activation of cytotoxic monocytes by free and liposome-encapsulated lymphokines. J Leukoc Biol. 1985 Apr; 37(4):461-72.
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Human lymphokine preparations which generate tumoricidal properties of human monocytes in vitro may be distinct from gamma interferon. Cancer Immunol Immunother. 1985; 20(2):151-7.
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Constitutive production and release of a lymphokine with macrophage-activating factor activity distinct from gamma-interferon by a human T-cell leukemia virus-positive cell line. Cancer Res. 1984 Oct; 44(10):4470-5.
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Lymphokine-activated human blood monocytes destroy tumor cells but not normal cells under cocultivation conditions. J Clin Oncol. 1984 Aug; 2(8):937-43.
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Tumoricidal activity of human monocytes: evidence for cytolytic function distinct from that of NK cells. J Immunol. 1984 Jul; 133(1):4-6.
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Human monocytes activated by immunomodulators in liposomes lyse herpesvirus-infected but not normal cells. Science. 1984 Jun 01; 224(4652):1007-9.