"HMGA1a Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An 11-kDa AT-hook motif-containing (AT-HOOK MOTIFS) protein that binds to the minor grove of AT-rich regions of DNA. It is the full-length product of the alternatively-spliced HMGA1 gene and may function as an architectural chromatin binding protein that is involved in transcriptional regulation.
| Descriptor ID |
D025741
|
| MeSH Number(s) |
D12.776.260.312.500 D12.776.660.235.400.500.100 D12.776.664.235.400.500.100
|
| Concept/Terms |
HMGA1a Protein- HMGA1a Protein
- High Mobility Group I(Y) Protein
- HMGI(Y) Gene Product
- HMG I-Y Phosphoprotein
- HMG I Y Phosphoprotein
- Phosphoprotein, HMG I-Y
- HMG-I(Y) Protein
- HMGI Protein
- AT-Hook 1a Protein, High Mobility Group
- AT Hook 1a Protein, High Mobility Group
- HMG I-Type Protein
- HMG I Type Protein
|
Below are MeSH descriptors whose meaning is more general than "HMGA1a Protein".
Below are MeSH descriptors whose meaning is more specific than "HMGA1a Protein".
This graph shows the total number of publications written about "HMGA1a Protein" by people in this website by year, and whether "HMGA1a Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 1997 | 0 | 1 | 1 |
| 2005 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
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Below are the most recent publications written about "HMGA1a Protein" by people in Profiles.
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The HMGA1-COX-2 axis: a key molecular pathway and potential target in pancreatic adenocarcinoma. Pancreatology. 2012 Jul-Aug; 12(4):372-9.
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Collective mass spectrometry approaches reveal broad and combinatorial modification of high mobility group protein A1a. J Am Soc Mass Spectrom. 2010 Jun; 21(6):960-70.
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HMGA1 correlates with advanced tumor grade and decreased survival in pancreatic ductal adenocarcinoma. Mod Pathol. 2010 Jan; 23(1):98-104.
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The AT-hook of the chromatin architectural transcription factor high mobility group A1a is arginine-methylated by protein arginine methyltransferase 6. J Biol Chem. 2006 Feb 17; 281(7):3764-72.
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Hepatic nuclear factor 3 and high mobility group I/Y proteins bind the insulin response element of the insulin-like growth factor-binding protein-1 promoter. Endocrinology. 1997 Oct; 138(10):4291-300.
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Multiple proteins bind the insulin response element in the human IGFBP-1 promoter. Prog Growth Factor Res. 1995; 6(2-4):93-101.
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Organization, inducible-expression and chromosome localization of the human HMG-I(Y) nonhistone protein gene. Nucleic Acids Res. 1993 Sep 11; 21(18):4259-67.