"Complement C4b" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The large fragment formed when COMPLEMENT C4 is cleaved by COMPLEMENT C1S. The membrane-bound C4b binds COMPLEMENT C2A, a SERINE PROTEASE, to form C4b2a (CLASSICAL PATHWAY C3 CONVERTASE) and subsequent C4b2a3b (CLASSICAL PATHWAY C5 CONVERTASE).
| Descriptor ID |
D015935
|
| MeSH Number(s) |
D12.776.124.486.274.350.260
|
| Concept/Terms |
Complement C4b- Complement C4b
- C4b, Complement
- Complement 4b
- Complement Component 4b
- Component 4b, Complement
- C4b Complement
- Complement, C4b
|
Below are MeSH descriptors whose meaning is more general than "Complement C4b".
Below are MeSH descriptors whose meaning is more specific than "Complement C4b".
This graph shows the total number of publications written about "Complement C4b" by people in this website by year, and whether "Complement C4b" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 1 | 1 |
| 2008 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2017 | 2 | 0 | 2 |
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Below are the most recent publications written about "Complement C4b" by people in Profiles.
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Plasma Levels of Complement Factor I and C4b Peptides Are Associated with HIV Suppression. ACS Infect Dis. 2017 12 08; 3(12):880-885.
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Routine C4d immunohistochemistry in cardiac allografts: Long-term outcomes. J Heart Lung Transplant. 2017 Dec; 36(12):1329-1335.
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C4d deposits on the surface of RBCs in trauma patients and interferes with their function. Crit Care Med. 2014 May; 42(5):e364-72.
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The presence of anti-HLA donor-specific antibodies in lung allograft recipients does not correlate with C4d immunofluorescence in transbronchial biopsy specimens. Arch Pathol Lab Med. 2014 Aug; 138(8):1053-8.
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Systemic lupus erythematosus serum deposits C4d on red blood cells, decreases red blood cell membrane deformability, and promotes nitric oxide production. Arthritis Rheum. 2011 Feb; 63(2):503-12.
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Significance and implications of capillaritis during acute rejection of kidney allografts. Transplantation. 2010 May 15; 89(9):1088-94.
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Genetic deficiency of complement isoforms C4A or C4B predicts improved survival of metastatic renal cell carcinoma. J Urol. 2009 Mar; 181(3):1028-34; discussion 1034.
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Donor-specific antibodies against HLA, MICA, and GSTT1 in patients with allograft rejection and C4d deposition in renal biopsies. Transplantation. 2009 Jan 15; 87(1):94-9.
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Immunohistochemistry staining of C4d to diagnose antibody-mediated rejection in cardiac transplantation. J Heart Lung Transplant. 2008 Apr; 27(4):372-9.
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Acute antibody-mediated rejection of renal transplant: pathogenetic and diagnostic considerations. Arch Pathol Lab Med. 2007 Aug; 131(8):1200-8.