"5'-Nucleotidase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A glycoprotein enzyme present in various organs and in many cells. The enzyme catalyzes the hydrolysis of a 5'-ribonucleotide to a ribonucleoside and orthophosphate in the presence of water. It is cation-dependent and exists in a membrane-bound and soluble form. EC 3.1.3.5.
| Descriptor ID |
D015720
|
| MeSH Number(s) |
D08.811.277.352.650.600.600
|
| Concept/Terms |
5'-Nucleotidase- 5'-Nucleotidase
- 5' Nucleotidase
- 5'-Nucleotidase Phosphoribolase
- 5' Nucleotidase Phosphoribolase
- Adenylate Phosphatase
- AMP Phosphatase
- Cytidylate Phosphatase
- Ecto-5'-Nucleotidase
- Ecto 5' Nucleotidase
- IMP Nucleotidase
- CD73 Antigens
- IMPase
- Inosinate Phosphatase
- Pyrimidine 5'-Nucleotidase
- Pyrimidine 5' Nucleotidase
- Thymidine Phosphatase
- Uridylate 5'-Nucleotidase
- Uridylate 5' Nucleotidase
- Antigen, CD73
- CD73 Antigen
- Antigens, CD73
- 5'-AMP Nucleotidase
- 5' AMP Nucleotidase
- IMP Phosphatase
|
Below are MeSH descriptors whose meaning is more general than "5'-Nucleotidase".
Below are MeSH descriptors whose meaning is more specific than "5'-Nucleotidase".
This graph shows the total number of publications written about "5'-Nucleotidase" by people in this website by year, and whether "5'-Nucleotidase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2007 | 0 | 2 | 2 |
| 2008 | 1 | 0 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 3 | 0 | 3 |
| 2013 | 1 | 2 | 3 |
| 2015 | 0 | 1 | 1 |
| 2016 | 3 | 0 | 3 |
| 2018 | 2 | 1 | 3 |
| 2019 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
| 2021 | 2 | 0 | 2 |
| 2022 | 1 | 1 | 2 |
| 2023 | 1 | 1 | 2 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "5'-Nucleotidase" by people in Profiles.
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Preventive Treatment with a CD73 Small Molecule Inhibitor Enhances Immune Surveillance in K-Ras Mutant Pancreatic Intraepithelial Neoplasia. Cancer Prev Res (Phila). 2024 Oct 01; 17(10):457-470.
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Exploring the Expression of Adenosine Pathway-Related Markers CD73 and CD39 in Colorectal and Pancreatic Carcinomas Characterized by Multiplex Immunofluorescence: A Pilot Study. Pathobiology. 2024; 91(3):205-218.
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CD73-Dependent Adenosine Signaling through Adora2b Drives Immunosuppression in Ductal Pancreatic Cancer. Cancer Res. 2023 04 04; 83(7):1111-1127.
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Second-Generation CD73 Inhibitors Based on a 4,6-Biaryl-2-thiopyridine Scaffold. ChemMedChem. 2023 04 03; 18(7):e202200594.
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Pharmacologic Inhibition of NT5C2 Reverses Genetic and Nongenetic Drivers of 6-MP Resistance in Acute Lymphoblastic Leukemia. Cancer Discov. 2022 11 02; 12(11):2646-2665.
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CD73 induces GM-CSF/MDSC-mediated suppression of T cells to accelerate pancreatic cancer pathogenesis. Oncogene. 2022 Feb; 41(7):971-982.
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CD73 induces gemcitabine resistance in pancreatic ductal adenocarcinoma: A promising target with non-canonical mechanisms. Cancer Lett. 2021 10 28; 519:289-303.
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CD73 expression defines immune, molecular, and clinicopathological subgroups of lung adenocarcinoma. Cancer Immunol Immunother. 2021 Jul; 70(7):1965-1976.
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4-Substituted-1,2,3-triazolo nucleotide analogues as CD73 inhibitors, their synthesis, in vitro screening, kinetic and in silico studies. Bioorg Chem. 2021 02; 107:104577.
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Profiling of patients with glioma reveals the dominant immunosuppressive axis is refractory to immune function restoration. JCI Insight. 2020 09 03; 5(17).