Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing)
"Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing)" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the formation of carbamoyl phosphate from ATP, carbon dioxide, and glutamine. This enzyme is important in the de novo biosynthesis of pyrimidines. EC 6.3.5.5.
| Descriptor ID |
D002223
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| MeSH Number(s) |
D08.811.464.259.400.300
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing)".
Below are MeSH descriptors whose meaning is more specific than "Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing)".
This graph shows the total number of publications written about "Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing)" by people in this website by year, and whether "Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing)" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 2 | 2 |
| 2012 | 1 | 0 | 1 |
| 2015 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing)" by people in Profiles.
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Cell-based analysis of CAD variants identifies individuals likely to benefit from uridine therapy. Genet Med. 2020 10; 22(10):1598-1605.
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Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures. Cell. 2018 09 06; 174(6):1559-1570.e22.
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Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis. Nature. 2015 Nov 19; 527(7578):379-383.
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Interaction of heat shock protein 90 and the co-chaperone Cpr6 with Ura2, a bifunctional enzyme required for pyrimidine biosynthesis. J Biol Chem. 2013 Sep 20; 288(38):27406-27414.
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The nucleotide synthesis enzyme CAD inhibits NOD2 antibacterial function in human intestinal epithelial cells. Gastroenterology. 2012 Jun; 142(7):1483-92.e6.
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Genomic instability driven by the human T-cell leukemia virus type I (HTLV-I) oncoprotein, Tax. Oncogene. 2002 Oct 17; 21(47):7230-4.
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Caspase-3-dependent and -independent apoptosis in focal brain ischemia. Mol Med. 2002 Jul; 8(7):347-52.