"Locus Control Region" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A regulatory region first identified in the human beta-globin locus but subsequently found in other loci. The region is believed to regulate GENETIC TRANSCRIPTION by opening and remodeling CHROMATIN structure. It may also have enhancer activity.
| Descriptor ID |
D019901
|
| MeSH Number(s) |
G02.111.570.080.689.450 G05.360.080.689.450 G05.360.340.024.380.249
|
| Concept/Terms |
Locus Control Region- Locus Control Region
- Control Region, Locus
- Control Regions, Locus
- Locus Control Regions
- Region, Locus Control
- Regions, Locus Control
|
Below are MeSH descriptors whose meaning is more general than "Locus Control Region".
Below are MeSH descriptors whose meaning is more specific than "Locus Control Region".
This graph shows the total number of publications written about "Locus Control Region" by people in this website by year, and whether "Locus Control Region" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 0 | 1 |
| 2008 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
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Below are the most recent publications written about "Locus Control Region" by people in Profiles.
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Complete genomic sequence of a new Human polyomavirus 9 strain with an altered noncoding control region. Virus Genes. 2014 Dec; 49(3):490-2.
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A sequence-level map of chromosomal breakpoints in the MCF-7 breast cancer cell line yields insights into the evolution of a cancer genome. Genome Res. 2009 Feb; 19(2):167-77.
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A facilitated tracking and transcription mechanism of long-range enhancer function. Nucleic Acids Res. 2007; 35(16):5532-44.
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HS2 enhancer function is blocked by a transcriptional terminator inserted between the enhancer and the promoter. J Biol Chem. 2004 Dec 03; 279(49):51704-13.
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Dynamic retrotransposition of ERV-9 LTR and L1 in the beta-globin gene locus during primate evolution. Mol Phylogenet Evol. 2004 Mar; 30(3):867-71.
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The LTR enhancer of ERV-9 human endogenous retrovirus is active in oocytes and progenitor cells in transgenic zebrafish and humans. Proc Natl Acad Sci U S A. 2004 Jan 20; 101(3):805-10.
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The ERV-9 LTR enhancer is not blocked by the HS5 insulator and synthesizes through the HS5 site non-coding, long RNAs that regulate LTR enhancer function. Nucleic Acids Res. 2003 Aug 01; 31(15):4582-96.
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Nuclear matrix association of the human beta-globin locus utilizing a novel approach to quantitative real-time PCR. Nucleic Acids Res. 2003 Jun 15; 31(12):3257-66.
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Hypersensitive site 2 specifies a unique function within the human beta-globin locus control region to stimulate globin gene transcription. Mol Cell Biol. 1999 Apr; 19(4):3062-72.