1-Methyl-4-phenylpyridinium
"1-Methyl-4-phenylpyridinium" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An active neurotoxic metabolite of 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE. The compound reduces dopamine levels, inhibits the biosynthesis of catecholamines, depletes cardiac norepinephrine and inactivates tyrosine hydroxylase. These and other toxic effects lead to cessation of oxidative phosphorylation, ATP depletion, and cell death. The compound, which is related to PARAQUAT, has also been used as an herbicide.
| Descriptor ID |
D015655
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| MeSH Number(s) |
D03.383.725.762.550
|
| Concept/Terms |
1-Methyl-4-phenylpyridinium- 1-Methyl-4-phenylpyridinium
- 1 Methyl 4 phenylpyridinium
- 1-Methyl-4-phenylpyridine
- 1 Methyl 4 phenylpyridine
- N-Methyl-4-phenylpyridinium
- N-Methyl-4-phenylpyridine
- N Methyl 4 phenylpyridine
- 1-Methyl-4-phenylpyridinium Ion
- 1 Methyl 4 phenylpyridinium Ion
- Cyperquat
|
Below are MeSH descriptors whose meaning is more general than "1-Methyl-4-phenylpyridinium".
Below are MeSH descriptors whose meaning is more specific than "1-Methyl-4-phenylpyridinium".
This graph shows the total number of publications written about "1-Methyl-4-phenylpyridinium" by people in this website by year, and whether "1-Methyl-4-phenylpyridinium" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 1 | 0 | 1 |
| 1999 | 1 | 0 | 1 |
| 2003 | 0 | 1 | 1 |
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Below are the most recent publications written about "1-Methyl-4-phenylpyridinium" by people in Profiles.
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Mitochondrial pyruvate carrier regulates autophagy, inflammation, and neurodegeneration in experimental models of Parkinson's disease. Sci Transl Med. 2016 12 07; 8(368):368ra174.
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The peptidyl-prolyl isomerase Pin1 up-regulation and proapoptotic function in dopaminergic neurons: relevance to the pathogenesis of Parkinson disease. J Biol Chem. 2013 Jul 26; 288(30):21955-71.
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Effects of green tea polyphenols on dopamine uptake and on MPP+ -induced dopamine neuron injury. Life Sci. 2003 Jan 17; 72(9):1073-83.
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Characterization of MPP(+)-induced cell death in a dopaminergic neuronal cell line: role of macromolecule synthesis, cytosolic calcium, caspase, and Bcl-2-related proteins. Exp Neurol. 1999 Sep; 159(1):274-82.
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(-)-Deprenyl protection of 1-methyl-4 phenylpyridium ion (MPP+)-induced apoptosis independent of MAO-B inhibition. Neurosci Lett. 1997 Mar 21; 224(3):197-200.