Peptide Chain Initiation, Translational
"Peptide Chain Initiation, Translational" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A process of GENETIC TRANSLATION whereby the formation of a peptide chain is started. It includes assembly of the RIBOSOME components, the MESSENGER RNA coding for the polypeptide to be made, INITIATOR TRNA, and PEPTIDE INITIATION FACTORS; and placement of the first amino acid in the peptide chain. The details and components of this process are unique for prokaryotic protein biosynthesis and eukaryotic protein biosynthesis.
| Descriptor ID |
D010442
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| MeSH Number(s) |
G02.111.660.871.650 G03.734.871.650
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| Concept/Terms |
Peptide Chain Initiation, Translational- Peptide Chain Initiation, Translational
- Chain Initiation, Peptide, Translational
- Protein Chain Initiation, Translational
- Protein Translation Initiation
- Translation Initiation, Protein
- Initiation, Protein Translation
- Protein Biosynthesis Initiation
- Biosynthesis Initiation, Protein
- Initiation, Protein Biosynthesis
- Translation Initiation, Genetic
- Genetic Translation Initiation
- Initiation, Genetic Translation
- Translational Peptide Chain Initiation
- Translational Initiation, Protein
- Initiation, Protein Translational
- Protein Translational Initiation
|
Below are MeSH descriptors whose meaning is more general than "Peptide Chain Initiation, Translational".
Below are MeSH descriptors whose meaning is more specific than "Peptide Chain Initiation, Translational".
This graph shows the total number of publications written about "Peptide Chain Initiation, Translational" by people in this website by year, and whether "Peptide Chain Initiation, Translational" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 1 | 0 | 1 |
| 2000 | 1 | 2 | 3 |
| 2002 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2021 | 1 | 1 | 2 |
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Below are the most recent publications written about "Peptide Chain Initiation, Translational" by people in Profiles.
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RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site. Cell Rep. 2021 11 02; 37(5):109934.
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Prematurity blunts the insulin- and amino acid-induced stimulation of translation initiation and protein synthesis in skeletal muscle of neonatal pigs. Am J Physiol Endocrinol Metab. 2021 03 01; 320(3):E551-E565.
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Messenger RNA Structure Regulates Translation Initiation: A Mechanism Exploited from Bacteria to Humans. Biochemistry. 2018 07 03; 57(26):3537-3539.
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Genome-wide identification and differential analysis of translational initiation. Nat Commun. 2017 11 23; 8(1):1749.
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Distribution and diversity of ribosome binding sites in prokaryotic genomes. BMC Genomics. 2015 Aug 14; 16:604.
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p53 acts as a safeguard of translational control by regulating fibrillarin and rRNA methylation in cancer. Cancer Cell. 2013 Sep 09; 24(3):318-30.
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Differential inhibition of protein translation machinery by curcumin in normal, immortalized, and malignant oral epithelial cells. Cancer Prev Res (Phila). 2010 Mar; 3(3):331-8.
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Effect of point mutations in translation initiation context on the expression of recombinant human alpha(1)-proteinase inhibitor in transgenic tomato plants. Plant Cell Rep. 2009 Dec; 28(12):1791-8.
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A small stem loop element directs internal initiation of the URE2 internal ribosome entry site in Saccharomyces cerevisiae. J Biol Chem. 2008 Jul 04; 283(27):19011-25.
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Hypoxia actively represses transcription by inducing negative cofactor 2 (Dr1/DrAP1) and blocking preinitiation complex assembly. J Biol Chem. 2003 Feb 21; 278(8):5744-9.