"Methylmalonic Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. Abnormalities in methylmalonic acid metabolism lead to methylmalonic aciduria. This metabolic disease is attributed to a block in the enzymatic conversion of methylmalonyl CoA to succinyl CoA.
| Descriptor ID |
D008764
|
| MeSH Number(s) |
D02.241.081.337.540.500
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Methylmalonic Acid".
Below are MeSH descriptors whose meaning is more specific than "Methylmalonic Acid".
This graph shows the total number of publications written about "Methylmalonic Acid" by people in this website by year, and whether "Methylmalonic Acid" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 1 | 0 | 1 |
| 2006 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Methylmalonic Acid" by people in Profiles.
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Aging-Associated Metabolite Methylmalonic Acid Increases Susceptibility to Pulmonary Fibrosis. Am J Pathol. 2024 08; 194(8):1478-1493.
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Solid organ transplantation in methylmalonic acidemia and propionic acidemia: A points to consider statement of the American College of Medical Genetics and Genomics (ACMG). Genet Med. 2023 02; 25(2):100337.
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Molecules in the blood of older people promote cancer spread. Nature. 2020 09; 585(7824):187-188.
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Maternal choline supplementation alters vitamin B-12 status in human and murine pregnancy. J Nutr Biochem. 2019 10; 72:108210.
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Identification and Quantitation of Malonic Acid Biomarkers of In-Born Error Metabolism by Targeted Metabolomics. J Am Soc Mass Spectrom. 2017 05; 28(5):929-938.
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Efficacy of early treatment in patients with cobalamin C disease identified by newborn screening: a 16-year experience. Genet Med. 2017 08; 19(8):926-935.
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Next generation sequencing of patients with mut methylmalonic aciduria: Validation of somatic cell studies and identification of 16 novel mutations. Mol Genet Metab. 2016 08; 118(4):264-71.
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Added value of next generation gene panel analysis for patients with elevated methylmalonic acid and no clinical diagnosis following functional studies of vitamin B12 metabolism. Mol Genet Metab. 2016 Mar; 117(3):363-8.
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Advances in mechanisms, diagnosis, and treatment of pernicious anemia. Discov Med. 2015 Mar; 19(104):159-68.
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Screen for abnormal mitochondrial phenotypes in mouse embryonic stem cells identifies a model for succinyl-CoA ligase deficiency and mtDNA depletion. Dis Model Mech. 2014 Feb; 7(2):271-80.