Glycine Hydroxymethyltransferase
"Glycine Hydroxymethyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A pyridoxal phosphate enzyme that catalyzes the reaction of glycine and 5,10-methylene-tetrahydrofolate to form serine. It also catalyzes the reaction of glycine with acetaldehyde to form L-threonine. EC 2.1.2.1.
| Descriptor ID |
D012696
|
| MeSH Number(s) |
D08.811.913.555.400.500
|
| Concept/Terms |
Glycine Hydroxymethyltransferase- Glycine Hydroxymethyltransferase
- Hydroxymethyltransferase, Glycine
- Allothreonine Aldolase
- Aldolase, Allothreonine
- Serine Transhydroxymethylase
- Transhydroxymethylase, Serine
- Serine Hydroxymethylase
- Hydroxymethylase, Serine
- Serine Hydroxymethyltransferase
- Hydroxymethyltransferase, Serine
- Threonine Aldolase
- Aldolase, Threonine
- Serine Aldolase
- Aldolase, Serine
|
Below are MeSH descriptors whose meaning is more general than "Glycine Hydroxymethyltransferase".
Below are MeSH descriptors whose meaning is more specific than "Glycine Hydroxymethyltransferase".
This graph shows the total number of publications written about "Glycine Hydroxymethyltransferase" by people in this website by year, and whether "Glycine Hydroxymethyltransferase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 |
| 1997 | 1 | 0 | 1 |
| 2005 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Glycine Hydroxymethyltransferase" by people in Profiles.
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Concurrent loss of LKB1 and KEAP1 enhances SHMT-mediated antioxidant defence in KRAS-mutant lung cancer. Nat Metab. 2024 Jul; 6(7):1310-1328.
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Nuclear enrichment of folate cofactors and methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) protect de novo thymidylate biosynthesis during folate deficiency. J Biol Chem. 2014 Oct 24; 289(43):29642-50.
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Serine catabolism regulates mitochondrial redox control during hypoxia. Cancer Discov. 2014 Dec; 4(12):1406-17.
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Variants in folate pathway genes as modulators of genetic instability and lung cancer risk. Genes Chromosomes Cancer. 2011 Jan; 50(1):1-12.
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Polymorphisms of cytosolic serine hydroxymethyltransferase and risk of lung cancer: a case-control analysis. Lung Cancer. 2007 Aug; 57(2):143-51.
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Polymorphisms and haplotypes of serine hydroxymethyltransferase and risk of squamous cell carcinoma of the head and neck: a case-control analysis. Pharmacogenet Genomics. 2005 Aug; 15(8):557-64.
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Molecular cloning, characterization, and regulation of the human mitochondrial serine hydroxymethyltransferase gene. J Biol Chem. 1997 Jan 17; 272(3):1842-8.
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Haploinsufficiency of cytosolic serine hydroxymethyltransferase in the Smith-Magenis syndrome. Am J Hum Genet. 1995 Dec; 57(6):1342-50.
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Increased activity of renal glycine-cleavage-enzyme complex in metabolic acidosis. Biochem J. 1985 Oct 15; 231(2):477-80.